DegronMD

Uniprot ID: Q9P2K3

Source protein: REST corepressor 3

Source gene: RCOR3

Class: DEG_SCF_FBW7_1

Location: 398:405

E3 ligase: FBXW7

DEGRON score: 0.8138

ASA_SCORE: 96.325

COIL: 0.9691

CONS_SCORE: 0.2653

DSS_SCORE: 0.827

HELIX: 0.0142

FCONS_SCORE: 0.8858

RIG_SCORE: 0.512

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R392W	TCGA-AA-3984	COAD	TCGA	PSSTPTPT	DEG_SCF_FBW7_1	0.1667
p.R392W	DO9002	COAD	ICGC	PSSTPTPT	DEG_SCF_FBW7_1	0.1667
p.E396Q	TCGA-BT-A2LA	BLCA	TCGA	PSSTPTPT	DEG_SCF_FBW7_1	0.2778
p.E396Q	DO561	BLCA	ICGC	PSSTPTPT	DEG_SCF_FBW7_1	0.2778
p.D414N	DO52646	BOCA	ICGC	PSSTPTPT	DEG_SCF_FBW7_1	0.0833
p.G404S	DO10639	COAD	ICGC	PSSTPTPT	DEG_SCF_FBW7_1	0.6993
p.R391C	DO222762	COCA	ICGC	PSSTPTPT	DEG_SCF_FBW7_1	0.1389
p.R391C	DO233864	GACA	ICGC	PSSTPTPT	DEG_SCF_FBW7_1	0.1389
p.S392T	DO50306	ESAD	ICGC	PSSTPTPT	DEG_SCF_FBW7_1	0.1667
p.G404C	DO228985	LICA	ICGC	PSSTPTPT	DEG_SCF_FBW7_1	0.76
p.G404C	DO47112	RECA	ICGC	PSSTPTPT	DEG_SCF_FBW7_1	0.76
p.G404C	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	PSSTPTPT	DEG_SCF_FBW7_1	0.76
p.G413C	DO229035	LICA	ICGC	PSSTPTPT	DEG_SCF_FBW7_1	0.1111
p.C402R	DO47112	RECA	ICGC	PSSTPTPT	DEG_SCF_FBW7_1	0.8301
p.C402R	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	PSSTPTPT	DEG_SCF_FBW7_1	0.8301
p.C402R	DND-41	haematopoietic_and_lymphoid_tissue	COSMIC	PSSTPTPT	DEG_SCF_FBW7_1	0.8301
p.N394D	SIDM01095	Rhabdomyosarcoma	GDSC	PSSTPTPT	DEG_SCF_FBW7_1	0.2222
p.N394D	ACH-000833	Sarcoma	CCLE	PSSTPTPT	DEG_SCF_FBW7_1	0.2222
p.N394D	SJRH30	soft_tissue	COSMIC	PSSTPTPT	DEG_SCF_FBW7_1	0.2222
p.G413A	SIDM00845	Burkitt's Lymphoma	GDSC	PSSTPTPT	DEG_SCF_FBW7_1	0.1111
p.G413A	SIDM00035	Thyroid Gland Carcinoma	GDSC	PSSTPTPT	DEG_SCF_FBW7_1	0.1111
p.G413A	SIDM01519	Head and Neck Carcinoma	GDSC	PSSTPTPT	DEG_SCF_FBW7_1	0.1111
p.G413A	ACH-000786	Lymphoma	CCLE	PSSTPTPT	DEG_SCF_FBW7_1	0.1111
p.G413A	ACH-000992	Head and Neck Cancer	CCLE	PSSTPTPT	DEG_SCF_FBW7_1	0.1111
p.G413A	DND-41	haematopoietic_and_lymphoid_tissue	COSMIC	PSSTPTPT	DEG_SCF_FBW7_1	0.1111
p.G413A	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	PSSTPTPT	DEG_SCF_FBW7_1	0.1111
p.S411F	SIDM00721	Small Cell Lung Carcinoma	GDSC	PSSTPTPT	DEG_SCF_FBW7_1	0.1667
p.S411F	ACH-002171	Lung Cancer	CCLE	PSSTPTPT	DEG_SCF_FBW7_1	0.1667
p.S411F	NCI-H250	lung	COSMIC	PSSTPTPT	DEG_SCF_FBW7_1	0.1667
p.A406V	TOV-21G	ovary	COSMIC	PSSTPTPT	DEG_SCF_FBW7_1	0.3056
p.A406V	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	PSSTPTPT	DEG_SCF_FBW7_1	0.3056
p.A406V	S-117	soft_tissue	COSMIC	PSSTPTPT	DEG_SCF_FBW7_1	0.3056
p.P395L	KM12	large_intestine	COSMIC	PSSTPTPT	DEG_SCF_FBW7_1	0.25
p.T410I	MZ7-mel	skin	COSMIC	PSSTPTPT	DEG_SCF_FBW7_1	0.1944
p.A409T	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	PSSTPTPT	DEG_SCF_FBW7_1	0.2222
p.A408T	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	PSSTPTPT	DEG_SCF_FBW7_1	0.25

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PSSTPTPT

Degron related mutations and impact score

Drug responses associated with RCOR3 mutations

All proteins holding degron of PSSTPTPT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9P2K3	REST corepressor 3	DEG_SCF_FBW7_1	398:405	PSSTPTPT	FBXW7	0.8138	More...