DegronMD

Uniprot ID: Q9P2K3

Source protein: REST corepressor 3

Source gene: RCOR3

Class: DEG_APCC_DBOX_1

Location: 468:476

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7077

ASA_SCORE: 92.0444

COIL: 0.9558

CONS_SCORE: 0.336

DSS_SCORE: 0.707

HELIX: 0.0196

FCONS_SCORE: 0.9175

RIG_SCORE: 0.651

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P481L	TCGA-77-A5GF	LUSC	TCGA	PRPVLSTVG	DEG_APCC_DBOX_1	0.1944
p.P481L	DO50101	LUSC	ICGC	PRPVLSTVG	DEG_APCC_DBOX_1	0.1944
p.P484L	TCGA-A6-2686	COAD	TCGA	PRPVLSTVG	DEG_APCC_DBOX_1	0.1111
p.P484L	DO7828	COAD	ICGC	PRPVLSTVG	DEG_APCC_DBOX_1	0.1111
p.T459P	TCGA-A6-6780	COAD	TCGA	PRPVLSTVG	DEG_APCC_DBOX_1	0.0833
p.T459P	DO10244	COAD	ICGC	PRPVLSTVG	DEG_APCC_DBOX_1	0.0833
p.L469Q	TCGA-DD-A4NO	LIHC	TCGA	PRPVLSTVG	DEG_APCC_DBOX_1	0.7765
p.L469Q	DO45013	LIHC	ICGC	PRPVLSTVG	DEG_APCC_DBOX_1	0.7765
p.T463A	TCGA-RC-A7SB	LIHC	TCGA	PRPVLSTVG	DEG_APCC_DBOX_1	0.1944
p.T463A	DO219581	LIHC	ICGC	PRPVLSTVG	DEG_APCC_DBOX_1	0.1944
p.Q471H	DO228952	LICA	ICGC	PRPVLSTVG	DEG_APCC_DBOX_1	0.7582
p.A464V	SIDM00845	Burkitt's Lymphoma	GDSC	PRPVLSTVG	DEG_APCC_DBOX_1	0.2222
p.A464V	SIDM01169	Ovarian Carcinoma	GDSC	PRPVLSTVG	DEG_APCC_DBOX_1	0.2222
p.A464V	SIDM00035	Thyroid Gland Carcinoma	GDSC	PRPVLSTVG	DEG_APCC_DBOX_1	0.2222
p.A464V	SIDM00461	Acute Myeloid Leukemia	GDSC	PRPVLSTVG	DEG_APCC_DBOX_1	0.2222
p.A464V	SIDM00946	T-Lymphoblastic Leukemia	GDSC	PRPVLSTVG	DEG_APCC_DBOX_1	0.2222
p.A464V	SIDM01519	Head and Neck Carcinoma	GDSC	PRPVLSTVG	DEG_APCC_DBOX_1	0.2222
p.A464V	ACH-000037	Sarcoma	CCLE	PRPVLSTVG	DEG_APCC_DBOX_1	0.2222
p.A464V	ACH-000786	Lymphoma	CCLE	PRPVLSTVG	DEG_APCC_DBOX_1	0.2222
p.A464V	ACH-000885	Ovarian Cancer	CCLE	PRPVLSTVG	DEG_APCC_DBOX_1	0.2222
p.A464V	ACH-000992	Head and Neck Cancer	CCLE	PRPVLSTVG	DEG_APCC_DBOX_1	0.2222
p.A464V	S-117	soft_tissue	COSMIC	PRPVLSTVG	DEG_APCC_DBOX_1	0.2222
p.A464V	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	PRPVLSTVG	DEG_APCC_DBOX_1	0.2222
p.A464V	TOV-21G	ovary	COSMIC	PRPVLSTVG	DEG_APCC_DBOX_1	0.2222
p.T468I	SIDM00516	Melanoma	GDSC	PRPVLSTVG	DEG_APCC_DBOX_1	0.7078
p.T468I	ACH-002166	Skin Cancer	CCLE	PRPVLSTVG	DEG_APCC_DBOX_1	0.7078
p.T468I	MZ7-mel	skin	COSMIC	PRPVLSTVG	DEG_APCC_DBOX_1	0.7078
p.I484T	JHOS-2	ovary	COSMIC	PRPVLSTVG	DEG_APCC_DBOX_1	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PRPVLSTVG

Degron related mutations and impact score

Drug responses associated with RCOR3 mutations

All proteins holding degron of PRPVLSTVG

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9P2K3	REST corepressor 3	DEG_APCC_DBOX_1	468:476	PRPVLSTVG	APC,CDC20,FZR1	0.7077	More...