DegronMD

Uniprot ID: P51617

Source protein: Interleukin-1 receptor-associated kinase 1

Source gene: IRAK1

Class: DEG_APCC_DBOX_1

Location: 384:392

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7146

ASA_SCORE: 31.9444

COIL: 0.6216

CONS_SCORE: 0.6052

DSS_SCORE: 0.246

HELIX: 0.0519

FCONS_SCORE: 1.3008

RIG_SCORE: 0.8349

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S376R	TCGA-21-1083	LUSC	TCGA	VRGTLAYLP	DEG_APCC_DBOX_1	0.5556
p.L388M	TCGA-BS-A0V8	UCEC	TCGA	VRGTLAYLP	DEG_APCC_DBOX_1	0.711
p.T381S	TCGA-CK-4947	COAD	TCGA	VRGTLAYLP	DEG_APCC_DBOX_1	0.6944
p.L391V	TCGA-L5-A4OW	ESCA	TCGA	VRGTLAYLP	DEG_APCC_DBOX_1	0.5654
p.D375Y	DO227942	BRCA	ICGC	VRGTLAYLP	DEG_APCC_DBOX_1	0.5278
p.K381N	DO228957	LICA	ICGC	VRGTLAYLP	DEG_APCC_DBOX_1	0.6944
p.S399R	DO219517	LIHC	ICGC	VRGTLAYLP	DEG_APCC_DBOX_1	0.1389
p.G395V	DO231641	LINC	ICGC	VRGTLAYLP	DEG_APCC_DBOX_1	0.25
p.S402R	DO26769	LUSC	ICGC	VRGTLAYLP	DEG_APCC_DBOX_1	0.0556
p.G386C	DO220886	MELA	ICGC	VRGTLAYLP	DEG_APCC_DBOX_1	0.6489
p.E393K	SIDM00749	Non-Small Cell Lung Carcinoma	GDSC	VRGTLAYLP	DEG_APCC_DBOX_1	0.3056
p.E393K	ACH-000916	Lung Cancer	CCLE	VRGTLAYLP	DEG_APCC_DBOX_1	0.3056
p.E393K	NCI-H1573	lung	COSMIC	VRGTLAYLP	DEG_APCC_DBOX_1	0.3056

Drug responses associated with IRAK1 mutations

Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
SIDM00749	LUAD\|lung_NSCLC_adenocarcinoma	p.E393K (Yes)	GDSC	WZ3105	16.7536
SIDM00095	GBM\|glioma	p.R366C (No)	GDSC	WZ3105	0.6666
SIDM00932	KIRC\|kidney	p.V642M (No)	GDSC	WZ3105	4.9105
SIDM00651	UNCLASSIFIED\|lung_NSCLC_large_cell	p.P658L (No)	GDSC	WZ3105	24.2807
SIDM00212	GBM\|glioma	p.V642M (No)	GDSC	WZ3105	0.9105
SIDM01090	COREAD\|large_intestine	p.C203S (No)	GDSC	WZ3105	0.2097
SIDM00529	BRCA\|breast	p.P173L (No)	GDSC	WZ3105	0.5606
SIDM00756	LUAD\|lung_NSCLC_adenocarcinoma	p.S690G (No)	GDSC	WZ3105	25.4931
SIDM01186	BRCA\|breast	p.P162S (No)	GDSC	WZ3105	0.4924
SIDM00530	ESCA\|oesophagus	p.V586M (No)	GDSC	WZ3105	0.5288
SIDM00217	COREAD\|large_intestine	p.L437P (No)	GDSC	WZ3105	0.1618
SIDM00807	BLCA\|bladder	p.P173L (No)	GDSC	WZ3105	0.2911
SIDM00396	LAML\|acute_myeloid_leukaemia	p.R366C (No)	GDSC	WZ3105	0.0764
SIDM00274	STAD\|stomach	p.E516K (No)	GDSC	WZ3105	18.5283
SIDM00426	UNCLASSIFIED\|rhabdomyosarcoma	p.T152S (No)	GDSC	WZ3105	0.5116
SIDM00567	MB\|medulloblastoma	p.V188F (No)	GDSC	WZ3105	0.118
SIDM01140	UNCLASSIFIED\|ovary	p.P173L (No)	GDSC	WZ3105	0.213
SIDM01113	UNCLASSIFIED\|soft_tissue_other	p.R69fs*6 (No)	GDSC	WZ3105	1.6705
SIDM01183	UNCLASSIFIED\|lung_NSCLC_carcinoid	p.A651V (No)	GDSC	WZ3105	0.7103
SIDM00128	HNSC\|head_and_neck	p.G530R (No)	GDSC	WZ3105	0.3456
SIDM01004	LCML\|chronic_myeloid_leukaemia	p.L493_G494delLG (No)	GDSC	WZ3105	0.1956
SIDM00382	GBM\|glioma	p.P218fs*68 (No)	GDSC	WZ3105	27.5385
SIDM00555	GBM\|glioma	p.V586M (No)	GDSC	WZ3105	0.1686
SIDM00092	OV\|ovary	p.S607R (No)	GDSC	WZ3105	1.9954
SIDM00048	LUAD\|lung_NSCLC_adenocarcinoma	p.R194H (No)	GDSC	WZ3105	0.4596
SIDM00654	SCLC\|lung_small_cell_carcinoma	p.R187Q (No)	GDSC	WZ3105	0.262
SIDM00579	NB\|neuroblastoma	p.D169G (No)	GDSC	WZ3105	18.1424
SIDM00118	COREAD\|large_intestine	p.V642A (No)	GDSC	WZ3105	0.4527

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VRGTLAYLP

Degron related mutations and impact score

Drug responses associated with IRAK1 mutations

All proteins holding degron of VRGTLAYLP

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P51617	Interleukin-1 receptor-associated kinase 1	DEG_APCC_DBOX_1	384:392	VRGTLAYLP	APC,CDC20,FZR1	0.7146	More...