DegronMD

Uniprot ID: P51617

Source protein: Interleukin-1 receptor-associated kinase 1

Source gene: IRAK1

Class: DEG_COP1_1

Location: 154:164

E3 ligase: COP1

DEGRON score: 0.9977

ASA_SCORE: 75.1727

COIL: 0.9311

CONS_SCORE: 0.3238

DSS_SCORE: 0.6312

HELIX: 0.028

FCONS_SCORE: 0.9717

RIG_SCORE: 0.5949

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P148L	TCGA-23-2649	OV	TCGA	SGPELGLVPSP	DEG_COP1_1	0.1667
p.P169A	TCGA-A6-2683	COAD	TCGA	SGPELGLVPSP	DEG_COP1_1	0.1944
p.P156R	TCGA-ZF-A9RL	BLCA	TCGA	SGPELGLVPSP	DEG_COP1_1	0.6401
p.A172D	DO229041	LICA	ICGC	SGPELGLVPSP	DEG_COP1_1	0.1111
p.E152D	DO45346	LUAD	ICGC	SGPELGLVPSP	DEG_COP1_1	0.2778
p.P174L	DO31779	OV	ICGC	SGPELGLVPSP	DEG_COP1_1	0.0556
p.P162Q	DO37866	SKCM	ICGC	SGPELGLVPSP	DEG_COP1_1	0.7035
p.R159L	DO50279	SKCM	ICGC	SGPELGLVPSP	DEG_COP1_1	0.8428
p.T152S	SIDM00426	Rhabdomyosarcoma	GDSC	SGPELGLVPSP	DEG_COP1_1	0.2778
p.T152S	ACH-000100	Sarcoma	CCLE	SGPELGLVPSP	DEG_COP1_1	0.2778
p.T152S	ACH-001765	Sarcoma	CCLE	SGPELGLVPSP	DEG_COP1_1	0.2778
p.T152S	RH-41	soft_tissue	COSMIC	SGPELGLVPSP	DEG_COP1_1	0.2778
p.P162S	SIDM01186	Breast Carcinoma	GDSC	SGPELGLVPSP	DEG_COP1_1	0.6752
p.P162S	ACH-000554	Breast Cancer	CCLE	SGPELGLVPSP	DEG_COP1_1	0.6752
p.P162S	UACC-893	breast	COSMIC	SGPELGLVPSP	DEG_COP1_1	0.6752
p.A151T	RCH-ACV	haematopoietic_and_lymphoid_tissue	COSMIC	SGPELGLVPSP	DEG_COP1_1	0.25

Drug responses associated with IRAK1 mutations

Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
SIDM00749	LUAD\|lung_NSCLC_adenocarcinoma	p.E393K (No)	GDSC	WZ3105	16.7536
SIDM00095	GBM\|glioma	p.R366C (No)	GDSC	WZ3105	0.6666
SIDM00932	KIRC\|kidney	p.V642M (No)	GDSC	WZ3105	4.9105
SIDM00651	UNCLASSIFIED\|lung_NSCLC_large_cell	p.P658L (No)	GDSC	WZ3105	24.2807
SIDM00212	GBM\|glioma	p.V642M (No)	GDSC	WZ3105	0.9105
SIDM01090	COREAD\|large_intestine	p.C203S (No)	GDSC	WZ3105	0.2097
SIDM00529	BRCA\|breast	p.P173L (Yes)	GDSC	WZ3105	0.5606
SIDM00756	LUAD\|lung_NSCLC_adenocarcinoma	p.S690G (No)	GDSC	WZ3105	25.4931
SIDM01186	BRCA\|breast	p.P162S (Yes)	GDSC	WZ3105	0.4924
SIDM00530	ESCA\|oesophagus	p.V586M (No)	GDSC	WZ3105	0.5288
SIDM00217	COREAD\|large_intestine	p.L437P (No)	GDSC	WZ3105	0.1618
SIDM00807	BLCA\|bladder	p.P173L (Yes)	GDSC	WZ3105	0.2911
SIDM00396	LAML\|acute_myeloid_leukaemia	p.R366C (No)	GDSC	WZ3105	0.0764
SIDM00274	STAD\|stomach	p.E516K (No)	GDSC	WZ3105	18.5283
SIDM00426	UNCLASSIFIED\|rhabdomyosarcoma	p.T152S (Yes)	GDSC	WZ3105	0.5116
SIDM00567	MB\|medulloblastoma	p.V188F (No)	GDSC	WZ3105	0.118
SIDM01140	UNCLASSIFIED\|ovary	p.P173L (Yes)	GDSC	WZ3105	0.213
SIDM01113	UNCLASSIFIED\|soft_tissue_other	p.R69fs*6 (No)	GDSC	WZ3105	1.6705
SIDM01183	UNCLASSIFIED\|lung_NSCLC_carcinoid	p.A651V (No)	GDSC	WZ3105	0.7103
SIDM00128	HNSC\|head_and_neck	p.G530R (No)	GDSC	WZ3105	0.3456
SIDM01004	LCML\|chronic_myeloid_leukaemia	p.L493_G494delLG (No)	GDSC	WZ3105	0.1956
SIDM00382	GBM\|glioma	p.P218fs*68 (No)	GDSC	WZ3105	27.5385
SIDM00555	GBM\|glioma	p.V586M (No)	GDSC	WZ3105	0.1686
SIDM00092	OV\|ovary	p.S607R (No)	GDSC	WZ3105	1.9954
SIDM00048	LUAD\|lung_NSCLC_adenocarcinoma	p.R194H (No)	GDSC	WZ3105	0.4596
SIDM00654	SCLC\|lung_small_cell_carcinoma	p.R187Q (No)	GDSC	WZ3105	0.262
SIDM00579	NB\|neuroblastoma	p.D169G (Yes)	GDSC	WZ3105	18.1424
SIDM00118	COREAD\|large_intestine	p.V642A (No)	GDSC	WZ3105	0.4527

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: SGPELGLVPSP

Degron related mutations and impact score

Drug responses associated with IRAK1 mutations

All proteins holding degron of SGPELGLVPSP

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P51617	Interleukin-1 receptor-associated kinase 1	DEG_COP1_1	154:164	SGPELGLVPSP	COP1	0.9977	More...