DegronMD - Q8IXF0(NPAS3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D256H	TCGA-55-7995	LUAD	TCGA	VESTS	DEG_SPOP_SBC_1	245:249	Mutation rewiring degron network	0.1389
p.Q238K	TCGA-56-8083	LUSC	TCGA	ASSSS	DEG_SPOP_SBC_1	233:237	Mutation rewiring degron network	0.3056
p.Q238K	TCGA-56-8083	LUSC	TCGA	VESTS	DEG_SPOP_SBC_1	245:249	Mutation rewiring degron network	0.1389
p.S249C	TCGA-66-2768	LUSC	TCGA	VESTS	DEG_SPOP_SBC_1	245:249	Mutation altering degron motif	0.7541
p.E227K	TCGA-CR-6481	HNSC	TCGA	ASSSS	DEG_SPOP_SBC_1	233:237	Mutation rewiring degron network	0.1667
p.S249A	DO7801	COAD	ICGC	VESTS	DEG_SPOP_SBC_1	245:249	Mutation altering degron motif	0.7588
p.R242H	DO227976	COCA	ICGC	ASSSS	DEG_SPOP_SBC_1	233:237	Mutation rewiring degron network	0.1944
p.R242H	DO227976	COCA	ICGC	VESTS	DEG_SPOP_SBC_1	245:249	Mutation rewiring degron network	0.25
p.L227I	DO222762	COCA	ICGC	ASSSS	DEG_SPOP_SBC_1	233:237	Mutation rewiring degron network	0.1667
p.R242C	DO233642	GACA	ICGC	ASSSS	DEG_SPOP_SBC_1	233:237	Mutation rewiring degron network	0.1944
p.R242C	DO233642	GACA	ICGC	VESTS	DEG_SPOP_SBC_1	245:249	Mutation rewiring degron network	0.25
p.Q254H	DO229045	LICA	ICGC	VESTS	DEG_SPOP_SBC_1	245:249	Mutation rewiring degron network	0.1944
p.T240N	DO231587	LINC	ICGC	ASSSS	DEG_SPOP_SBC_1	233:237	Mutation rewiring degron network	0.25
p.T240N	DO231587	LINC	ICGC	VESTS	DEG_SPOP_SBC_1	245:249	Mutation rewiring degron network	0.1944
p.D224H	DO45323	LUAD	ICGC	ASSSS	DEG_SPOP_SBC_1	233:237	Mutation rewiring degron network	0.0833
p.R229P	DO230961	LUSC	ICGC	ASSSS	DEG_SPOP_SBC_1	233:237	Mutation rewiring degron network	0.2222
p.R229P	DO224594	LUSC	ICGC	ASSSS	DEG_SPOP_SBC_1	233:237	Mutation rewiring degron network	0.2222
p.I246S	DO26814	LUSC	ICGC	VESTS	DEG_SPOP_SBC_1	245:249	Mutation altering degron motif	0.7341
p.R229H	DO52151	PAEN	ICGC	ASSSS	DEG_SPOP_SBC_1	233:237	Mutation rewiring degron network	0.2222
p.R259W	DO220122	SARC	ICGC	VESTS	DEG_SPOP_SBC_1	245:249	Mutation rewiring degron network	0.0556
p.R259W	DO43755	UCEC	ICGC	VESTS	DEG_SPOP_SBC_1	245:249	Mutation rewiring degron network	0.0556
p.R229C	DO47813	STAD	ICGC	ASSSS	DEG_SPOP_SBC_1	233:237	Mutation rewiring degron network	0.2222
p.R229C	DO41871	UCEC	ICGC	ASSSS	DEG_SPOP_SBC_1	233:237	Mutation rewiring degron network	0.2222
p.T238N	DO43306	UCEC	ICGC	ASSSS	DEG_SPOP_SBC_1	233:237	Mutation rewiring degron network	0.3056
p.T238N	DO43306	UCEC	ICGC	VESTS	DEG_SPOP_SBC_1	245:249	Mutation rewiring degron network	0.1389
p.S247P	SIDM00434	Plasma Cell Myeloma	GDSC	VESTS	DEG_SPOP_SBC_1	245:249	Mutation altering degron motif	0.6752
p.S247P	MOLP-8	haematopoietic and lymphoid tissue	COSMIC	VESTS	DEG_SPOP_SBC_1	245:249	Mutation altering degron motif	0.6752
p.S252P	ACH-000745	Myeloma	CCLE	VESTS	DEG_SPOP_SBC_1	245:249	Mutation rewiring degron network	0.25
p.S252P	ACH-001673	Bile Duct Cancer	CCLE	VESTS	DEG_SPOP_SBC_1	245:249	Mutation rewiring degron network	0.25
p.S252P	MOLP-8	haematopoietic and lymphoid tissue	COSMIC	VESTS	DEG_SPOP_SBC_1	245:249	Mutation rewiring degron network	0.25
p.S234P	MOLP-8	haematopoietic and lymphoid tissue	COSMIC	ASSSS	DEG_SPOP_SBC_1	233:237	Mutation altering degron motif	0.5641

Kaplan plot for NPAS3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

NPAS3

UniProt ID: Q8IXF0

Entrez ID: 64067

Protein name: Neuronal PAS domain-containing protein 3 (Neuronal PAS3) (Basic-helix-loop-helix-PAS protein MOP6) (Class E basic helix-loop-helix protein 12) (bHLHe12) (Member of PAS protein 6) (PAS domain-containing protein 6)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for NPAS3 in