DegronMD - Q9P286(PAK5)

PAK5

Please click HERE for better display.

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A434G	SIDM00329	Hodgkin's Lymphoma	GDSC	FRAALQLVV	DEG_APCC_DBOX_1	432:440	Mutation altering degron motif	0.6429
p.A434G	L-540	haematopoietic and lymphoid tissue	COSMIC	FRAALQLVV	DEG_APCC_DBOX_1	432:440	Mutation altering degron motif	0.6429
p.A450V	SIDM00676	Bladder Carcinoma	GDSC	FRAALQLVV	DEG_APCC_DBOX_1	432:440	Mutation rewiring degron network	0.0556
p.A450V	HT-1197	urinary tract	COSMIC	FRAALQLVV	DEG_APCC_DBOX_1	432:440	Mutation rewiring degron network	0.0556
p.P227L	SIDM00727	Non-Small Cell Lung Carcinoma	GDSC	ASSSS	DEG_SPOP_SBC_1	222:226	Mutation rewiring degron network	0.3056
p.P227L	NCI-H2342	lung	COSMIC	ASSSS	DEG_SPOP_SBC_1	222:226	Mutation rewiring degron network	0.3056
p.S223L	SIDM01059	Melanoma	GDSC	ASSSS	DEG_SPOP_SBC_1	222:226	Mutation altering degron motif	0.6556
p.S223L	IPC-298	skin	COSMIC	ASSSS	DEG_SPOP_SBC_1	222:226	Mutation altering degron motif	0.6556

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc