DegronMD

Uniprot ID: Q9P286

Source protein: Serine/threonine-protein kinase PAK 5

Source gene: PAK5

Class: DEG_APCC_DBOX_1

Location: 432:440

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6615

ASA_SCORE: 48.5111

COIL: 0.1947

CONS_SCORE: 0.5472

DSS_SCORE: 0.4269

HELIX: 0.7849

FCONS_SCORE: 1.1608

RIG_SCORE: 0.7964

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A434G	SIDM00329	Hodgkin's Lymphoma	GDSC	FRAALQLVV	DEG_APCC_DBOX_1	0.6429
p.A434G	L-540	haematopoietic_and_lymphoid_tissue	COSMIC	FRAALQLVV	DEG_APCC_DBOX_1	0.6429
p.A450V	SIDM00676	Bladder Carcinoma	GDSC	FRAALQLVV	DEG_APCC_DBOX_1	0.0556
p.A450V	HT-1197	urinary_tract	COSMIC	FRAALQLVV	DEG_APCC_DBOX_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9P286	Serine/threonine-protein kinase PAK 5	DEG_APCC_DBOX_1	432:440	FRAALQLVV	APC,CDC20,FZR1	0.6615	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons