DegronMD

Uniprot ID: O43474

Source protein: Krueppel-like factor 4

Source gene: KLF4

Class: DEG_SPOP_SBC_1

Location: 130:134

E3 ligase: SPOP

DEGRON score: 0.7205

ASA_SCORE: 88.1

COIL: 0.9642

CONS_SCORE: 0.3635

DSS_SCORE: 0.4653

HELIX: 0.0282

FCONS_SCORE: 0.9096

RIG_SCORE: 0.4835

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S134L	IGROV-1	ovary	COSMIC	ASSSS	DEG_SPOP_SBC_1	0.7667
p.S129P	TCGA-CA-6717	COAD	TCGA	ASSSS	DEG_SPOP_SBC_1	0.3056
p.S129P	DO8264	COAD	ICGC	ASSSS	DEG_SPOP_SBC_1	0.3056
p.D128E	NCI-H727	lung	COSMIC	ASSSS	DEG_SPOP_SBC_1	0.2778
p.L137F	SW684	soft_tissue	COSMIC	ASSSS	DEG_SPOP_SBC_1	0.25
p.S138N	ACH-001991	Primary	CCLE	ASSSS	DEG_SPOP_SBC_1	0.2222
p.V124M	TCGA-5M-AAT6	COAD	TCGA	ASSSS	DEG_SPOP_SBC_1	0.1667
p.V124M	DO223703	COAD	ICGC	ASSSS	DEG_SPOP_SBC_1	0.1667
p.Q123H	NCI-H2227	lung	COSMIC	ASSSS	DEG_SPOP_SBC_1	0.1389
p.K142N	H513	pleura	COSMIC	ASSSS	DEG_SPOP_SBC_1	0.1111
p.A121V	SIDM01619	Endometrial Carcinoma	GDSC	ASSSS	DEG_SPOP_SBC_1	0.0833
p.A121V	ACH-000984	Endometrial/Uterine Cancer	CCLE	ASSSS	DEG_SPOP_SBC_1	0.0833

Showing 1 to 12 of 12 entries

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Drug responses associated with KLF4 mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of ASSSS

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UKB5	Adherens junction-associated protein 1	DEG_SPOP_SBC_1	131:135	ASSSS	SPOP	0.9942	More...
Q96L96	Alpha-protein kinase 3	DEG_SPOP_SBC_1	767:771	ASSSS	SPOP	0.9904	More...
Q8TCU4	Alstrom syndrome protein 1	DEG_SPOP_SBC_1	1891:1895	ASSSS	SPOP	0.9753	More...
Q8TCU4	Alstrom syndrome protein 1	DEG_SPOP_SBC_1	3245:3249	ASSSS	SPOP	0.9886	More...
O14497	AT-rich interactive domain-containing protein 1A	DEG_SPOP_SBC_1	259:263	ASSSS	SPOP	0.8451	More...
Q8IVW6	AT-rich interactive domain-containing protein 3B	DEG_SPOP_SBC_1	532:536	ASSSS	SPOP	0.9828	More...
O15265	Ataxin-7	DEG_SPOP_SBC_1	214:218	ASSSS	SPOP	0.9963	More...
O00571	ATP-dependent RNA helicase DDX3X	DEG_SPOP_SBC_1	608:612	ASSSS	SPOP	0.9984	More...
Q8N143	B-cell CLL/lymphoma 6 member B protein	DEG_SPOP_SBC_1	233:237	ASSSS	SPOP	0.8845	More...
Q9ULI2	Beta-citrylglutamate synthase B	DEG_SPOP_SBC_1	346:350	ASSSS	SPOP	0.9949	More...
P54132	Bloom syndrome protein	DEG_SPOP_SBC_1	311:315	ASSSS	SPOP	0.9518	More...
Q9NSI6	Bromodomain and WD repeat-containing protein 1	DEG_SPOP_SBC_1	1544:1548	ASSSS	SPOP	0.9686	More...
P25440	Bromodomain-containing protein 2	DEG_SPOP_SBC_1	776:780	ASSSS	SPOP	0.9929	More...
Q12791	Calcium-activated potassium channel subunit alpha-1	DEG_SPOP_SBC_1	38:42	ASSSS	SPOP	0.9676	More...
Q08AD1	Calmodulin-regulated spectrin-associated protein 2	DEG_SPOP_SBC_1	689:693	ASSSS	SPOP	0.9974	More...
Q5VT06	Centrosome-associated protein 350	DEG_SPOP_SBC_1	708:712	ASSSS	SPOP	0.9973	More...
Q6NT52	Choriogonadotropin subunit beta variant 2	DEG_SPOP_SBC_1	135:139	ASSSS	SPOP	0.9986	More...
Q3L8U1	Chromodomain-helicase-DNA-binding protein 9	DEG_SPOP_SBC_1	2174:2178	ASSSS	SPOP	0.9639	More...
Q9UJ98	Cohesin subunit SA-3	DEG_SPOP_SBC_1	18:22	ASSSS	SPOP	0.9571	More...
Q9NQR7	Coiled-coil domain-containing protein 177	DEG_SPOP_SBC_1	250:254	ASSSS	SPOP	0.9585	More...
Q9UFE4	Coiled-coil domain-containing protein 39	DEG_SPOP_SBC_1	927:931	ASSSS	SPOP	0.9527	More...
Q02388	Collagen alpha-1	DEG_SPOP_SBC_1	697:701	ASSSS	SPOP	0.9041	More...
Q9NPF5	DNA methyltransferase 1-associated protein 1	DEG_SPOP_SBC_1	455:459	ASSSS	SPOP	0.7946	More...
Q5VTR2	E3 ubiquitin-protein ligase BRE1A	DEG_SPOP_SBC_1	163:167	ASSSS	SPOP	0.5674	More...
Q2Q1W2	E3 ubiquitin-protein ligase TRIM71	DEG_SPOP_SBC_1	31:35	ASSSS	SPOP	0.8838	More...

Showing 1 to 25 of 135 entries

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ASSSS

Degron related mutations and impact score

Drug responses associated with KLF4 mutations

All proteins holding degron of ASSSS