DegronMD - Q5VV67(PPRC1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.M875I	TCGA-55-A57B	LUAD	TCGA	SVSPAVPTP	DEG_COP1_1	864:872	Mutation rewiring degron network	0.25
p.M875I	DO218929	LUAD	ICGC	SVSPAVPTP	DEG_COP1_1	864:872	Mutation rewiring degron network	0.25
p.S974G	TCGA-60-2711	LUSC	TCGA	PYSST	DEG_SPOP_SBC_1	972:976	Mutation altering degron motif	0.6993
p.S974G	DO26987	LUSC	ICGC	PYSST	DEG_SPOP_SBC_1	972:976	Mutation altering degron motif	0.6993
p.P981S	TCGA-AD-5900	COAD	TCGA	PPPAPVSPY	DEG_SIAH_1	965:973	Mutation rewiring degron network	0.1111
p.P981S	TCGA-AD-5900	COAD	TCGA	PYSST	DEG_SPOP_SBC_1	972:976	Mutation rewiring degron network	0.1944
p.P981S	DO8514	COAD	ICGC	PPPAPVSPY	DEG_SIAH_1	965:973	Mutation rewiring degron network	0.1111
p.P981S	DO8514	COAD	ICGC	PYSST	DEG_SPOP_SBC_1	972:976	Mutation rewiring degron network	0.1944
p.A1219V	TCGA-AX-A1CE	UCEC	TCGA	LTPPAT	DEG_SCF_FBW7_1	1228:1233	Mutation rewiring degron network	0.0833
p.A1219V	DO42280	UCEC	ICGC	LTPPAT	DEG_SCF_FBW7_1	1228:1233	Mutation rewiring degron network	0.0833
p.V970I	TCGA-B0-5701	KIRC	TCGA	PPPAPVSPY	DEG_SIAH_1	965:973	Mutation altering degron motif	0.7076
p.V970I	DO227984	COCA	ICGC	PPPAPVSPY	DEG_SIAH_1	965:973	Mutation altering degron motif	0.7076
p.V970I	DO16240	KIRC	ICGC	PPPAPVSPY	DEG_SIAH_1	965:973	Mutation altering degron motif	0.7076
p.Q863H	TCGA-B5-A1N2	UCEC	TCGA	SVSPAVPTP	DEG_COP1_1	864:872	Mutation rewiring degron network	0.3056
p.Q863H	DO41602	UCEC	ICGC	SVSPAVPTP	DEG_COP1_1	864:872	Mutation rewiring degron network	0.3056
p.P872S	TCGA-BG-A0LX	UCEC	TCGA	SVSPAVPTP	DEG_COP1_1	864:872	Mutation altering degron motif	0.6752
p.P872S	DO41919	UCEC	ICGC	SVSPAVPTP	DEG_COP1_1	864:872	Mutation altering degron motif	0.6752
p.A1120V	TCGA-D1-A17Q	UCEC	TCGA	VPTPRQS	DEG_SCF_FBW7_1	1121:1127	Mutation rewiring degron network	0.3056
p.P1114H	TCGA-D3-A2J8	SKCM	TCGA	VPTPRQS	DEG_SCF_FBW7_1	1121:1127	Mutation rewiring degron network	0.1389
p.P626L	TCGA-DF-A2KU	UCEC	TCGA	ASTSS	DEG_SPOP_SBC_1	615:619	Mutation rewiring degron network	0.1389
p.P626L	DO223286	UCEC	ICGC	ASTSS	DEG_SPOP_SBC_1	615:619	Mutation rewiring degron network	0.1389
p.P626S	TCGA-EE-A2MR	SKCM	TCGA	ASTSS	DEG_SPOP_SBC_1	615:619	Mutation rewiring degron network	0.1389
p.P626S	DO37819	SKCM	ICGC	ASTSS	DEG_SPOP_SBC_1	615:619	Mutation rewiring degron network	0.1389
p.S1127N	TCGA-EO-A22R	UCEC	TCGA	VPTPRQS	DEG_SCF_FBW7_1	1121:1127	Mutation altering degron motif	0.7069
p.S1447L	TCGA-EO-A22U	UCEC	TCGA	ASSSS	DEG_SPOP_SBC_1	1440:1444	Mutation blocking phosphorylation signal	0.6944
p.S1447L	DO43755	UCEC	ICGC	ASSSS	DEG_SPOP_SBC_1	1440:1444	Mutation blocking phosphorylation signal	0.6944
p.G980A	TCGA-FI-A2EW	UCEC	TCGA	PPPAPVSPY	DEG_SIAH_1	965:973	Mutation rewiring degron network	0.1389
p.G980A	TCGA-FI-A2EW	UCEC	TCGA	PYSST	DEG_SPOP_SBC_1	972:976	Mutation rewiring degron network	0.2222
p.G980A	DO41500	UCEC	ICGC	PPPAPVSPY	DEG_SIAH_1	965:973	Mutation rewiring degron network	0.1389
p.G980A	DO41500	UCEC	ICGC	PYSST	DEG_SPOP_SBC_1	972:976	Mutation rewiring degron network	0.2222
p.S1450L	TCGA-FT-A3EE	BLCA	TCGA	ASSSS	DEG_SPOP_SBC_1	1440:1444	Mutation blocking phosphorylation signal	0.6111
p.S1450L	DO720	BLCA	ICGC	ASSSS	DEG_SPOP_SBC_1	1440:1444	Mutation blocking phosphorylation signal	0.6111
p.R1454W	TCGA-GF-A6C9	SKCM	TCGA	ASSSS	DEG_SPOP_SBC_1	1440:1444	Mutation rewiring degron network	0.0556
p.R1454W	DO51254	SKCM	ICGC	ASSSS	DEG_SPOP_SBC_1	1440:1444	Mutation rewiring degron network	0.0556
p.R1454W	SIDM01617	Endometrial Carcinoma	GDSC	ASSSS	DEG_SPOP_SBC_1	1440:1444	Mutation rewiring degron network	0.0556
p.R1454W	ACH-000994	Endometrial/Uterine Cancer	CCLE	ASSSS	DEG_SPOP_SBC_1	1440:1444	Mutation rewiring degron network	0.0556
p.Q1126H	TCGA-IR-A3LA	CESC	TCGA	VPTPRQS	DEG_SCF_FBW7_1	1121:1127	Mutation altering degron motif	0.647
p.D605N	DO218976	BLCA	ICGC	ASTSS	DEG_SPOP_SBC_1	615:619	Mutation rewiring degron network	0.0556
p.V609I	DO4155	BRCA	ICGC	ASTSS	DEG_SPOP_SBC_1	615:619	Mutation rewiring degron network	0.1667
p.W984C	DO229378	BTCA	ICGC	PYSST	DEG_SPOP_SBC_1	972:976	Mutation rewiring degron network	0.1111
p.S1444F	DO50341	ESAD	ICGC	ASSSS	DEG_SPOP_SBC_1	1440:1444	Mutation altering degron motif	0.9093
p.D614H	DO219080	HNSC	ICGC	ASTSS	DEG_SPOP_SBC_1	615:619	Mutation rewiring degron network	0.3056
p.S1233P	DO231140	LAML	ICGC	LTPPAT	DEG_SCF_FBW7_1	1228:1233	Mutation altering degron motif	0.6752
p.V609L	DO229027	LICA	ICGC	ASTSS	DEG_SPOP_SBC_1	615:619	Mutation rewiring degron network	0.1667
p.S1451Y	DO231577	LINC	ICGC	ASSSS	DEG_SPOP_SBC_1	1440:1444	Mutation blocking phosphorylation signal	0.5833
p.T620A	DO50825	LIRI	ICGC	ASTSS	DEG_SPOP_SBC_1	615:619	Mutation rewiring degron network	0.3056
p.A1219T	DO45155	LIRI	ICGC	LTPPAT	DEG_SCF_FBW7_1	1228:1233	Mutation rewiring degron network	0.0833
p.S1446L	DO23543	LIRI	ICGC	ASSSS	DEG_SPOP_SBC_1	1440:1444	Mutation blocking phosphorylation signal	0.7222
p.S1235F	DO23782	LUAD	ICGC	LTPPAT	DEG_SCF_FBW7_1	1228:1233	Mutation rewiring degron network	0.2778
p.S1226L	DO51407	PRAD	ICGC	LTPPAT	DEG_SCF_FBW7_1	1228:1233	Mutation rewiring degron network	0.2778
p.S1226L	DO50076	UCEC	ICGC	LTPPAT	DEG_SCF_FBW7_1	1228:1233	Mutation rewiring degron network	0.2778
p.S1223F	DO229459	SKCA	ICGC	LTPPAT	DEG_SCF_FBW7_1	1228:1233	Mutation rewiring degron network	0.1944
p.S615P	DO38631	STAD	ICGC	ASTSS	DEG_SPOP_SBC_1	615:619	Mutation altering degron motif	0.6752
p.H1236Y	DO229213	THCA	ICGC	LTPPAT	DEG_SCF_FBW7_1	1228:1233	Mutation rewiring degron network	0.25
p.R1238H	DO41644	UCEC	ICGC	LTPPAT	DEG_SCF_FBW7_1	1228:1233	Mutation rewiring degron network	0.1944
p.S611G	DO41784	UCEC	ICGC	ASTSS	DEG_SPOP_SBC_1	615:619	Mutation rewiring degron network	0.2222
p.S1220L	DO43891	UCEC	ICGC	LTPPAT	DEG_SCF_FBW7_1	1228:1233	Mutation rewiring degron network	0.1111
p.S1220L	DO42793	UCEC	ICGC	LTPPAT	DEG_SCF_FBW7_1	1228:1233	Mutation rewiring degron network	0.1111
p.S1220L	SNU-1040	large intestine	COSMIC	LTPPAT	DEG_SCF_FBW7_1	1228:1233	Mutation rewiring degron network	0.1111
p.A856V	SIDM02021	Esophageal Carcinoma	GDSC	SVSPAVPTP	DEG_COP1_1	864:872	Mutation rewiring degron network	0.1111
p.A856V	ACH-001656	Leukemia	CCLE	SVSPAVPTP	DEG_COP1_1	864:872	Mutation rewiring degron network	0.1111
p.P609S	SIDM00683	Prostate Carcinoma	GDSC	ASTSS	DEG_SPOP_SBC_1	615:619	Mutation rewiring degron network	0.1667
p.P609S	SIDM00842	Colorectal Carcinoma	GDSC	ASTSS	DEG_SPOP_SBC_1	615:619	Mutation rewiring degron network	0.1667
p.L1228I	SIDM00984	Other Blood Cancers	GDSC	LTPPAT	DEG_SCF_FBW7_1	1228:1233	Mutation altering degron motif	0.6063
p.L1228I	SIDM00652	Small Cell Lung Carcinoma	GDSC	LTPPAT	DEG_SCF_FBW7_1	1228:1233	Mutation altering degron motif	0.6063
p.L1228I	SIDM01780	B-Cell Non-Hodgkin's Lymphoma	GDSC	LTPPAT	DEG_SCF_FBW7_1	1228:1233	Mutation altering degron motif	0.6063
p.L1228I	SIDM01766	Chondrosarcoma	GDSC	LTPPAT	DEG_SCF_FBW7_1	1228:1233	Mutation altering degron motif	0.6063
p.S866F	SIDM01007	T-Lymphoblastic Leukemia	GDSC	SVSPAVPTP	DEG_COP1_1	864:872	Mutation altering degron motif	0.7982
p.S866F	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	SVSPAVPTP	DEG_COP1_1	864:872	Mutation altering degron motif	0.7982
p.V1121G	SIDM01240	Melanoma	GDSC	VPTPRQS	DEG_SCF_FBW7_1	1121:1127	Mutation altering degron motif	0.7532
p.V1121G	ACH-001002	Skin Cancer	CCLE	VPTPRQS	DEG_SCF_FBW7_1	1121:1127	Mutation altering degron motif	0.7532
p.V1121G	451Lu	skin	COSMIC	VPTPRQS	DEG_SCF_FBW7_1	1121:1127	Mutation altering degron motif	0.7532
p.P962L	SIDM01055	Glioblastoma	GDSC	PPPAPVSPY	DEG_SIAH_1	965:973	Mutation rewiring degron network	0.25
p.P962L	SIDM01055	Glioblastoma	GDSC	PYSST	DEG_SPOP_SBC_1	972:976	Mutation rewiring degron network	0.0556
p.P962L	ACH-000098	Brain Cancer	CCLE	PPPAPVSPY	DEG_SIAH_1	965:973	Mutation rewiring degron network	0.25
p.P962L	ACH-000098	Brain Cancer	CCLE	PYSST	DEG_SPOP_SBC_1	972:976	Mutation rewiring degron network	0.0556
p.P962L	GAMG	central nervous system	COSMIC	PPPAPVSPY	DEG_SIAH_1	965:973	Mutation rewiring degron network	0.25
p.P962L	GAMG	central nervous system	COSMIC	PYSST	DEG_SPOP_SBC_1	972:976	Mutation rewiring degron network	0.0556
p.G1227E	SIDM00032	Bladder Carcinoma	GDSC	LTPPAT	DEG_SCF_FBW7_1	1228:1233	Mutation rewiring degron network	0.3056
p.G1227E	SCaBER	urinary tract	COSMIC	LTPPAT	DEG_SCF_FBW7_1	1228:1233	Mutation rewiring degron network	0.3056
p.A1243G	SIDM01029	Esophageal Squamous Cell Carcinoma	GDSC	LTPPAT	DEG_SCF_FBW7_1	1228:1233	Mutation rewiring degron network	0.0556
p.A1243G	ACH-000873	Esophageal Cancer	CCLE	LTPPAT	DEG_SCF_FBW7_1	1228:1233	Mutation rewiring degron network	0.0556
p.A1243G	KYSE-270	oesophagus	COSMIC	LTPPAT	DEG_SCF_FBW7_1	1228:1233	Mutation rewiring degron network	0.0556
p.S619P	SIDM00859	B-Cell Non-Hodgkin's Lymphoma	GDSC	ASTSS	DEG_SPOP_SBC_1	615:619	Mutation altering degron motif	0.6752
p.S619P	ACH-001498	Lymphoma	CCLE	ASTSS	DEG_SPOP_SBC_1	615:619	Mutation altering degron motif	0.6752
p.S619P	Farage	haematopoietic and lymphoid tissue	COSMIC	ASTSS	DEG_SPOP_SBC_1	615:619	Mutation altering degron motif	0.6752
p.L1222P	SIDM00500	Colorectal Carcinoma	GDSC	LTPPAT	DEG_SCF_FBW7_1	1228:1233	Mutation rewiring degron network	0.1667
p.L1222P	ACH-000959	Colon/Colorectal Cancer	CCLE	LTPPAT	DEG_SCF_FBW7_1	1228:1233	Mutation rewiring degron network	0.1667
p.C959W	ACH-000870	Lung Cancer	CCLE	PPPAPVSPY	DEG_SIAH_1	965:973	Mutation rewiring degron network	0.1667
p.L629I	DND-41	haematopoietic and lymphoid tissue	COSMIC	ASTSS	DEG_SPOP_SBC_1	615:619	Mutation rewiring degron network	0.0556
p.P1242S	EGI-1	biliary tract	COSMIC	LTPPAT	DEG_SCF_FBW7_1	1228:1233	Mutation rewiring degron network	0.0833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PPRC1

UniProt ID: Q5VV67

Entrez ID: 23082

Protein name: Peroxisome proliferator-activated receptor gamma coactivator-related protein 1 (PGC-1-related coactivator) (PRC)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for PPRC1 in