DegronMD

Uniprot ID: Q5VV67

Source protein: Peroxisome proliferator-activated receptor gamma coactivator-related protein 1

Source gene: PPRC1

Class: DEG_COP1_1

Location: 864:872

E3 ligase: COP1

DEGRON score: 0.9932

ASA_SCORE: 88.6444

COIL: 0.9676

CONS_SCORE: 0.3244

DSS_SCORE: 0.5591

HELIX: 0.0102

FCONS_SCORE: 0.877

RIG_SCORE: 0.5841

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M875I	TCGA-55-A57B	LUAD	TCGA	SVSPAVPTP	DEG_COP1_1	0.25
p.M875I	DO218929	LUAD	ICGC	SVSPAVPTP	DEG_COP1_1	0.25
p.Q863H	TCGA-B5-A1N2	UCEC	TCGA	SVSPAVPTP	DEG_COP1_1	0.3056
p.Q863H	DO41602	UCEC	ICGC	SVSPAVPTP	DEG_COP1_1	0.3056
p.P872S	TCGA-BG-A0LX	UCEC	TCGA	SVSPAVPTP	DEG_COP1_1	0.6752
p.P872S	DO41919	UCEC	ICGC	SVSPAVPTP	DEG_COP1_1	0.6752
p.A856V	SIDM02021	Esophageal Carcinoma	GDSC	SVSPAVPTP	DEG_COP1_1	0.1111
p.A856V	ACH-001656	Leukemia	CCLE	SVSPAVPTP	DEG_COP1_1	0.1111
p.S866F	SIDM01007	T-Lymphoblastic Leukemia	GDSC	SVSPAVPTP	DEG_COP1_1	0.7982
p.S866F	KARPAS-45	haematopoietic_and_lymphoid_tissue	COSMIC	SVSPAVPTP	DEG_COP1_1	0.7982

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5VV67	Peroxisome proliferator-activated receptor gamma coactivator-related protein 1	DEG_COP1_1	864:872	SVSPAVPTP	COP1	0.9932	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons