DegronMD

Uniprot ID: Q5VV67

Source protein: Peroxisome proliferator-activated receptor gamma coactivator-related protein 1

Source gene: PPRC1

Class: DEG_SPOP_SBC_1

Location: 972:976

E3 ligase: SPOP

DEGRON score: 0.9181

ASA_SCORE: 96.94

COIL: 0.9526

CONS_SCORE: 0.5274

DSS_SCORE: 0.2892

HELIX: 0.024

FCONS_SCORE: 0.9732

RIG_SCORE: 0.6969

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S974G	TCGA-60-2711	LUSC	TCGA	PYSST	DEG_SPOP_SBC_1	0.6993
p.S974G	DO26987	LUSC	ICGC	PYSST	DEG_SPOP_SBC_1	0.6993
p.P981S	TCGA-AD-5900	COAD	TCGA	PYSST	DEG_SPOP_SBC_1	0.1944
p.P981S	DO8514	COAD	ICGC	PYSST	DEG_SPOP_SBC_1	0.1944
p.G980A	TCGA-FI-A2EW	UCEC	TCGA	PYSST	DEG_SPOP_SBC_1	0.2222
p.G980A	DO41500	UCEC	ICGC	PYSST	DEG_SPOP_SBC_1	0.2222
p.W984C	DO229378	BTCA	ICGC	PYSST	DEG_SPOP_SBC_1	0.1111
p.P962L	SIDM01055	Glioblastoma	GDSC	PYSST	DEG_SPOP_SBC_1	0.0556
p.P962L	ACH-000098	Brain Cancer	CCLE	PYSST	DEG_SPOP_SBC_1	0.0556
p.P962L	GAMG	central_nervous_system	COSMIC	PYSST	DEG_SPOP_SBC_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A1L4H1	Soluble scavenger receptor cysteine-rich domain-containing protein SSC5D	DEG_SPOP_SBC_1	1131:1135	PYSST	SPOP	0.9205	More...
Q5VV67	Peroxisome proliferator-activated receptor gamma coactivator-related protein 1	DEG_SPOP_SBC_1	972:976	PYSST	SPOP	0.9181	More...
Q9BSJ6	Protein PIMREG	DEG_SPOP_SBC_1	186:190	PYSST	SPOP	0.9992	More...
Q5VWK0	Neuroblastoma breakpoint family member 6	DEG_SPOP_SBC_1	454:458	PYSST	SPOP	0.9861	More...
Q96M43	Neuroblastoma breakpoint family member 4	DEG_SPOP_SBC_1	454:458	PYSST	SPOP	0.9948	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons