DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
PYSST
Uniprot ID:
Q96M43
Source protein:
Neuroblastoma breakpoint family member 4
Source gene:
NBPF4
Class:
DEG_SPOP_SBC_1
Location:
454:458
E3 ligase:
SPOP
DEGRON score:
0.9948
ASA_SCORE:
70.34
COIL:
0.8088
CONS_SCORE:
0.7209
DSS_SCORE:
0.4173
HELIX:
0.119
FCONS_SCORE:
1.286
RIG_SCORE:
0.7184
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with NBPF4 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PYSST
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
A1L4H1
Soluble scavenger receptor cysteine-rich domain-containing protein SSC5D
DEG_SPOP_SBC_1
1131:1135
PYSST
SPOP
0.9205
More...
Q5VV67
Peroxisome proliferator-activated receptor gamma coactivator-related protein 1
DEG_SPOP_SBC_1
972:976
PYSST
SPOP
0.9181
More...
Q9BSJ6
Protein PIMREG
DEG_SPOP_SBC_1
186:190
PYSST
SPOP
0.9992
More...
Q5VWK0
Neuroblastoma breakpoint family member 6
DEG_SPOP_SBC_1
454:458
PYSST
SPOP
0.9861
More...
Q96M43
Neuroblastoma breakpoint family member 4
DEG_SPOP_SBC_1
454:458
PYSST
SPOP
0.9948
More...