DegronMD

Uniprot ID: Q9BSJ6

Source protein: Protein PIMREG

Source gene: PIMREG

Class: DEG_SPOP_SBC_1

Location: 186:190

E3 ligase: SPOP

DEGRON score: 0.9992

ASA_SCORE: 70.34

COIL: 0.8684

CONS_SCORE: 0.8555

DSS_SCORE: 0.5607

HELIX: 0.0832

FCONS_SCORE: 1.1176

RIG_SCORE: 0.614

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R179W	SIDM01307	Colorectal Carcinoma	GDSC	PYSST	DEG_SPOP_SBC_1	0.1389
p.A182V	SIDM01612	Endometrial Carcinoma	GDSC	PYSST	DEG_SPOP_SBC_1	0.2222
p.R176Q	SUP-B15	haematopoietic_and_lymphoid_tissue	COSMIC	PYSST	DEG_SPOP_SBC_1	0.0556
p.R176Q	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	PYSST	DEG_SPOP_SBC_1	0.0556
p.R176Q	DOK	upper_aerodigestive_tract	COSMIC	PYSST	DEG_SPOP_SBC_1	0.0556
p.R176Q	HCC-366	lung	COSMIC	PYSST	DEG_SPOP_SBC_1	0.0556
p.R193C	TE-5	oesophagus	COSMIC	PYSST	DEG_SPOP_SBC_1	0.25
p.R193C	SiHa	cervix	COSMIC	PYSST	DEG_SPOP_SBC_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A1L4H1	Soluble scavenger receptor cysteine-rich domain-containing protein SSC5D	DEG_SPOP_SBC_1	1131:1135	PYSST	SPOP	0.9205	More...
Q5VV67	Peroxisome proliferator-activated receptor gamma coactivator-related protein 1	DEG_SPOP_SBC_1	972:976	PYSST	SPOP	0.9181	More...
Q9BSJ6	Protein PIMREG	DEG_SPOP_SBC_1	186:190	PYSST	SPOP	0.9992	More...
Q5VWK0	Neuroblastoma breakpoint family member 6	DEG_SPOP_SBC_1	454:458	PYSST	SPOP	0.9861	More...
Q96M43	Neuroblastoma breakpoint family member 4	DEG_SPOP_SBC_1	454:458	PYSST	SPOP	0.9948	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons