DegronMD

Uniprot ID: A1L4H1

Source protein: Soluble scavenger receptor cysteine-rich domain-containing protein SSC5D

Source gene: SSC5D

Class: DEG_SPOP_SBC_1

Location: 1131:1135

E3 ligase: SPOP

DEGRON score: 0.9205

ASA_SCORE: 78.6

COIL: 0.7456

CONS_SCORE: 0.3649

DSS_SCORE: 0.7399

HELIX: 0.0526

FCONS_SCORE: -0.0016

RIG_SCORE: 0.6347

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Y1139H	DO23610	LUAD	ICGC	PYSST	DEG_SPOP_SBC_1	0.2222
p.S1140F	SIDM01002	Breast Carcinoma	GDSC	PYSST	DEG_SPOP_SBC_1	0.1944
p.S1140F	ACH-000117	Breast Cancer	CCLE	PYSST	DEG_SPOP_SBC_1	0.1944
p.S1140F	EFM-192A	breast	COSMIC	PYSST	DEG_SPOP_SBC_1	0.1944
p.S1140Y	ACH-001846	Bile Duct Cancer	CCLE	PYSST	DEG_SPOP_SBC_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A1L4H1	Soluble scavenger receptor cysteine-rich domain-containing protein SSC5D	DEG_SPOP_SBC_1	1131:1135	PYSST	SPOP	0.9205	More...
Q5VV67	Peroxisome proliferator-activated receptor gamma coactivator-related protein 1	DEG_SPOP_SBC_1	972:976	PYSST	SPOP	0.9181	More...
Q9BSJ6	Protein PIMREG	DEG_SPOP_SBC_1	186:190	PYSST	SPOP	0.9992	More...
Q5VWK0	Neuroblastoma breakpoint family member 6	DEG_SPOP_SBC_1	454:458	PYSST	SPOP	0.9861	More...
Q96M43	Neuroblastoma breakpoint family member 4	DEG_SPOP_SBC_1	454:458	PYSST	SPOP	0.9948	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons