DegronMD

Uniprot ID: Q5VV67

Source protein: Peroxisome proliferator-activated receptor gamma coactivator-related protein 1

Source gene: PPRC1

Class: DEG_SCF_FBW7_1

Location: 1228:1233

E3 ligase: FBXW7

DEGRON score: 0.9986

ASA_SCORE: 84.8333

COIL: 0.9612

CONS_SCORE: 0.6649

DSS_SCORE: 0.5125

HELIX: 0.0137

FCONS_SCORE: 1.234

RIG_SCORE: 0.6314

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A1219V	TCGA-AX-A1CE	UCEC	TCGA	LTPPAT	DEG_SCF_FBW7_1	0.0833
p.A1219V	DO42280	UCEC	ICGC	LTPPAT	DEG_SCF_FBW7_1	0.0833
p.S1233P	DO231140	LAML	ICGC	LTPPAT	DEG_SCF_FBW7_1	0.6752
p.A1219T	DO45155	LIRI	ICGC	LTPPAT	DEG_SCF_FBW7_1	0.0833
p.S1235F	DO23782	LUAD	ICGC	LTPPAT	DEG_SCF_FBW7_1	0.2778
p.S1226L	DO51407	PRAD	ICGC	LTPPAT	DEG_SCF_FBW7_1	0.2778
p.S1226L	DO50076	UCEC	ICGC	LTPPAT	DEG_SCF_FBW7_1	0.2778
p.S1223F	DO229459	SKCA	ICGC	LTPPAT	DEG_SCF_FBW7_1	0.1944
p.H1236Y	DO229213	THCA	ICGC	LTPPAT	DEG_SCF_FBW7_1	0.25
p.R1238H	DO41644	UCEC	ICGC	LTPPAT	DEG_SCF_FBW7_1	0.1944
p.S1220L	DO43891	UCEC	ICGC	LTPPAT	DEG_SCF_FBW7_1	0.1111
p.S1220L	DO42793	UCEC	ICGC	LTPPAT	DEG_SCF_FBW7_1	0.1111
p.S1220L	SNU-1040	large_intestine	COSMIC	LTPPAT	DEG_SCF_FBW7_1	0.1111
p.L1228I	SIDM00984	Other Blood Cancers	GDSC	LTPPAT	DEG_SCF_FBW7_1	0.6063
p.L1228I	SIDM00652	Small Cell Lung Carcinoma	GDSC	LTPPAT	DEG_SCF_FBW7_1	0.6063
p.L1228I	SIDM01780	B-Cell Non-Hodgkin's Lymphoma	GDSC	LTPPAT	DEG_SCF_FBW7_1	0.6063
p.L1228I	SIDM01766	Chondrosarcoma	GDSC	LTPPAT	DEG_SCF_FBW7_1	0.6063
p.G1227E	SIDM00032	Bladder Carcinoma	GDSC	LTPPAT	DEG_SCF_FBW7_1	0.3056
p.G1227E	SCaBER	urinary_tract	COSMIC	LTPPAT	DEG_SCF_FBW7_1	0.3056
p.A1243G	SIDM01029	Esophageal Squamous Cell Carcinoma	GDSC	LTPPAT	DEG_SCF_FBW7_1	0.0556
p.A1243G	ACH-000873	Esophageal Cancer	CCLE	LTPPAT	DEG_SCF_FBW7_1	0.0556
p.A1243G	KYSE-270	oesophagus	COSMIC	LTPPAT	DEG_SCF_FBW7_1	0.0556
p.L1222P	SIDM00500	Colorectal Carcinoma	GDSC	LTPPAT	DEG_SCF_FBW7_1	0.1667
p.L1222P	ACH-000959	Colon/Colorectal Cancer	CCLE	LTPPAT	DEG_SCF_FBW7_1	0.1667
p.P1242S	EGI-1	biliary_tract	COSMIC	LTPPAT	DEG_SCF_FBW7_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5VV67	Peroxisome proliferator-activated receptor gamma coactivator-related protein 1	DEG_SCF_FBW7_1	1228:1233	LTPPAT	FBXW7	0.9986	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LTPPAT

Degron related mutations and impact score

Drug responses associated with PPRC1 mutations

All proteins holding degron of LTPPAT