DegronMD

Uniprot ID: Q5VV67

Source protein: Peroxisome proliferator-activated receptor gamma coactivator-related protein 1

Source gene: PPRC1

Class: DEG_SCF_FBW7_1

Location: 1121:1127

E3 ligase: FBXW7

DEGRON score: 0.9857

ASA_SCORE: 103.3857

COIL: 0.9603

CONS_SCORE: 0.4619

DSS_SCORE: 0.6981

HELIX: 0.0147

FCONS_SCORE: 1.0351

RIG_SCORE: 0.6251

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A1120V	TCGA-D1-A17Q	UCEC	TCGA	VPTPRQS	DEG_SCF_FBW7_1	0.3056
p.P1114H	TCGA-D3-A2J8	SKCM	TCGA	VPTPRQS	DEG_SCF_FBW7_1	0.1389
p.S1127N	TCGA-EO-A22R	UCEC	TCGA	VPTPRQS	DEG_SCF_FBW7_1	0.7069
p.Q1126H	TCGA-IR-A3LA	CESC	TCGA	VPTPRQS	DEG_SCF_FBW7_1	0.647
p.V1121G	SIDM01240	Melanoma	GDSC	VPTPRQS	DEG_SCF_FBW7_1	0.7532
p.V1121G	ACH-001002	Skin Cancer	CCLE	VPTPRQS	DEG_SCF_FBW7_1	0.7532
p.V1121G	451Lu	skin	COSMIC	VPTPRQS	DEG_SCF_FBW7_1	0.7532

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5VV67	Peroxisome proliferator-activated receptor gamma coactivator-related protein 1	DEG_SCF_FBW7_1	1121:1127	VPTPRQS	FBXW7	0.9857	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons