DegronMD

Uniprot ID: Q5VV67

Source protein: Peroxisome proliferator-activated receptor gamma coactivator-related protein 1

Source gene: PPRC1

Class: DEG_SIAH_1

Location: 965:973

E3 ligase: SIAH1,SIAH2,SIAH3

DEGRON score: 0.5679

ASA_SCORE: 97.9333

COIL: 0.9689

CONS_SCORE: 0.5643

DSS_SCORE: 0.2574

HELIX: 0.0131

FCONS_SCORE: 1.0567

RIG_SCORE: 0.6809

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P981S	TCGA-AD-5900	COAD	TCGA	PPPAPVSPY	DEG_SIAH_1	0.1111
p.P981S	DO8514	COAD	ICGC	PPPAPVSPY	DEG_SIAH_1	0.1111
p.V970I	TCGA-B0-5701	KIRC	TCGA	PPPAPVSPY	DEG_SIAH_1	0.7076
p.V970I	DO227984	COCA	ICGC	PPPAPVSPY	DEG_SIAH_1	0.7076
p.V970I	DO16240	KIRC	ICGC	PPPAPVSPY	DEG_SIAH_1	0.7076
p.G980A	TCGA-FI-A2EW	UCEC	TCGA	PPPAPVSPY	DEG_SIAH_1	0.1389
p.G980A	DO41500	UCEC	ICGC	PPPAPVSPY	DEG_SIAH_1	0.1389
p.P962L	SIDM01055	Glioblastoma	GDSC	PPPAPVSPY	DEG_SIAH_1	0.25
p.P962L	ACH-000098	Brain Cancer	CCLE	PPPAPVSPY	DEG_SIAH_1	0.25
p.P962L	GAMG	central_nervous_system	COSMIC	PPPAPVSPY	DEG_SIAH_1	0.25
p.C959W	ACH-000870	Lung Cancer	CCLE	PPPAPVSPY	DEG_SIAH_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5VV67	Peroxisome proliferator-activated receptor gamma coactivator-related protein 1	DEG_SIAH_1	965:973	PPPAPVSPY	SIAH1,SIAH2,SIAH3	0.5679	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons