DegronMD - O75581(LRP6)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R1523W	TCGA-02-0047	GBM	TCGA	PPTTPCST	DEG_SCF_FBW7_1	1527:1534	Mutation rewiring degron network	0.2222
p.Y1541S	TCGA-55-8614	LUAD	TCGA	PPTTPCST	DEG_SCF_FBW7_1	1527:1534	Mutation blocking phosphorylation signal	0.5833
p.R1462P	TCGA-CN-6997	HNSC	TCGA	ASSSS	DEG_SPOP_SBC_1	1468:1472	Mutation rewiring degron network	0.1667
p.P1519S	TCGA-FI-A2D0	UCEC	TCGA	PPTTPCST	DEG_SCF_FBW7_1	1527:1534	Mutation rewiring degron network	0.1111
p.H1524Q	TCGA-GL-A59R	KIRP	TCGA	PPTTPCST	DEG_SCF_FBW7_1	1527:1534	Mutation rewiring degron network	0.25
p.H1524Y	TCGA-IB-7651	PAAD	TCGA	PPTTPCST	DEG_SCF_FBW7_1	1527:1534	Mutation rewiring degron network	0.25
p.S1463R	DO7798	COAD	ICGC	ASSSS	DEG_SPOP_SBC_1	1468:1472	Mutation rewiring degron network	0.1944
p.R1478W	DO11669	GBM	ICGC	ASSSS	DEG_SPOP_SBC_1	1468:1472	Mutation rewiring degron network	0.1667
p.H1479Q	DO44525	KIRP	ICGC	ASSSS	DEG_SPOP_SBC_1	1468:1472	Mutation blocking phosphorylation signal	0.5833
p.Q1531K	DO229019	LICA	ICGC	PPTTPCST	DEG_SCF_FBW7_1	1527:1534	Mutation altering degron motif	0.6944
p.P1525H	DO229015	LICA	ICGC	PPTTPCST	DEG_SCF_FBW7_1	1527:1534	Mutation rewiring degron network	0.2778
p.N1462K	DO229024	LICA	ICGC	ASSSS	DEG_SPOP_SBC_1	1468:1472	Mutation rewiring degron network	0.1667
p.T1527K	DO229041	LICA	ICGC	PPTTPCST	DEG_SCF_FBW7_1	1527:1534	Mutation altering degron motif	0.7306
p.Y1475C	DO50950	LICA	ICGC	ASSSS	DEG_SPOP_SBC_1	1468:1472	Mutation blocking phosphorylation signal	0.6944
p.Y1475C	DO23146	LINC	ICGC	ASSSS	DEG_SPOP_SBC_1	1468:1472	Mutation blocking phosphorylation signal	0.6944
p.Y1475C	DO45071	LINC	ICGC	ASSSS	DEG_SPOP_SBC_1	1468:1472	Mutation blocking phosphorylation signal	0.6944
p.S1534P	DO26260	LUAD	ICGC	PPTTPCST	DEG_SCF_FBW7_1	1527:1534	Mutation altering degron motif	0.6752
p.P1474L	DO220856	MELA	ICGC	ASSSS	DEG_SPOP_SBC_1	1468:1472	Mutation blocking phosphorylation signal	0.7222
p.H1479Y	DO46657	PAAD	ICGC	ASSSS	DEG_SPOP_SBC_1	1468:1472	Mutation blocking phosphorylation signal	0.5833
p.G1458E	DO50280	SKCM	ICGC	ASSSS	DEG_SPOP_SBC_1	1468:1472	Mutation rewiring degron network	0.0556
p.R1529Q	DO41758	UCEC	ICGC	PPTTPCST	DEG_SCF_FBW7_1	1527:1534	Mutation altering degron motif	0.7329
p.P1474S	DO43891	UCEC	ICGC	ASSSS	DEG_SPOP_SBC_1	1468:1472	Mutation blocking phosphorylation signal	0.7222
p.S1460Y	DO42713	UCEC	ICGC	ASSSS	DEG_SPOP_SBC_1	1468:1472	Mutation blocking phosphorylation signal	0.5556
p.Y1520H	SIDM02041	Colorectal Carcinoma	GDSC	PPTTPCST	DEG_SCF_FBW7_1	1527:1534	Mutation blocking phosphorylation signal	0.5833
p.A1463V	SIDM00789	Colorectal Carcinoma	GDSC	ASSSS	DEG_SPOP_SBC_1	1468:1472	Mutation rewiring degron network	0.1944
p.A1463V	HCT-15	large intestine	COSMIC	ASSSS	DEG_SPOP_SBC_1	1468:1472	Mutation rewiring degron network	0.1944
p.P1458L	SIDM01067	Non-Small Cell Lung Carcinoma	GDSC	ASSSS	DEG_SPOP_SBC_1	1468:1472	Mutation rewiring degron network	0.0556
p.P1458L	HCC-827	lung	COSMIC	ASSSS	DEG_SPOP_SBC_1	1468:1472	Mutation rewiring degron network	0.0556
p.P1458S	SIDM01067	Non-Small Cell Lung Carcinoma	GDSC	ASSSS	DEG_SPOP_SBC_1	1468:1472	Mutation rewiring degron network	0.0556
p.P1458S	HCC-827	lung	COSMIC	ASSSS	DEG_SPOP_SBC_1	1468:1472	Mutation rewiring degron network	0.0556
p.R1523Q	SIDM01033	Bladder Carcinoma	GDSC	PPTTPCST	DEG_SCF_FBW7_1	1527:1534	Mutation rewiring degron network	0.2222
p.R1523Q	SIDM01612	Endometrial Carcinoma	GDSC	PPTTPCST	DEG_SCF_FBW7_1	1527:1534	Mutation rewiring degron network	0.2222
p.R1523Q	KU-19-19	urinary tract	COSMIC	PPTTPCST	DEG_SCF_FBW7_1	1527:1534	Mutation rewiring degron network	0.2222
p.V1536I	SIDM01619	Endometrial Carcinoma	GDSC	PPTTPCST	DEG_SCF_FBW7_1	1527:1534	Mutation rewiring degron network	0.2778
p.P1458F	ACH-000012	Lung Cancer	CCLE	ASSSS	DEG_SPOP_SBC_1	1468:1472	Mutation rewiring degron network	0.0556
p.R1478Q	KU-19-19	urinary tract	COSMIC	ASSSS	DEG_SPOP_SBC_1	1468:1472	Mutation rewiring degron network	0.1667

Kaplan plot for LRP6 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

LRP6

UniProt ID: O75581

Entrez ID: 4040

Protein name: Low-density lipoprotein receptor-related protein 6 (LRP-6)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for LRP6 in