DegronMD

Uniprot ID: O75581

Source protein: Low-density lipoprotein receptor-related protein 6

Source gene: LRP6

Class: DEG_SCF_FBW7_1

Location: 1527:1534

E3 ligase: FBXW7

DEGRON score: 0.998

ASA_SCORE: 69.5625

COIL: 0.9105

CONS_SCORE: 0.5182

DSS_SCORE: 0.3048

HELIX: 0.0348

FCONS_SCORE: 1.2699

RIG_SCORE: 0.6964

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1523W	TCGA-02-0047	GBM	TCGA	PPTTPCST	DEG_SCF_FBW7_1	0.2222
p.Y1541S	TCGA-55-8614	LUAD	TCGA	PPTTPCST	DEG_SCF_FBW7_1	0.5833
p.P1519S	TCGA-FI-A2D0	UCEC	TCGA	PPTTPCST	DEG_SCF_FBW7_1	0.1111
p.H1524Q	TCGA-GL-A59R	KIRP	TCGA	PPTTPCST	DEG_SCF_FBW7_1	0.25
p.H1524Y	TCGA-IB-7651	PAAD	TCGA	PPTTPCST	DEG_SCF_FBW7_1	0.25
p.Q1531K	DO229019	LICA	ICGC	PPTTPCST	DEG_SCF_FBW7_1	0.6944
p.P1525H	DO229015	LICA	ICGC	PPTTPCST	DEG_SCF_FBW7_1	0.2778
p.T1527K	DO229041	LICA	ICGC	PPTTPCST	DEG_SCF_FBW7_1	0.7306
p.S1534P	DO26260	LUAD	ICGC	PPTTPCST	DEG_SCF_FBW7_1	0.6752
p.R1529Q	DO41758	UCEC	ICGC	PPTTPCST	DEG_SCF_FBW7_1	0.7329
p.Y1520H	SIDM02041	Colorectal Carcinoma	GDSC	PPTTPCST	DEG_SCF_FBW7_1	0.5833
p.R1523Q	SIDM01033	Bladder Carcinoma	GDSC	PPTTPCST	DEG_SCF_FBW7_1	0.2222
p.R1523Q	SIDM01612	Endometrial Carcinoma	GDSC	PPTTPCST	DEG_SCF_FBW7_1	0.2222
p.R1523Q	KU-19-19	urinary_tract	COSMIC	PPTTPCST	DEG_SCF_FBW7_1	0.2222
p.V1536I	SIDM01619	Endometrial Carcinoma	GDSC	PPTTPCST	DEG_SCF_FBW7_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75197	Low-density lipoprotein receptor-related protein 5	DEG_SCF_FBW7_1	1538:1545	PPTTPCST	FBXW7	0.9143	More...
O75581	Low-density lipoprotein receptor-related protein 6	DEG_SCF_FBW7_1	1527:1534	PPTTPCST	FBXW7	0.998	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons