DegronMD

Uniprot ID: O75197

Source protein: Low-density lipoprotein receptor-related protein 5

Source gene: LRP5

Class: DEG_SCF_FBW7_1

Location: 1538:1545

E3 ligase: FBXW7

DEGRON score: 0.9143

ASA_SCORE: 64.275

COIL: 0.9011

CONS_SCORE: 0.5225

DSS_SCORE: 0.3572

HELIX: 0.0568

FCONS_SCORE: 1.223

RIG_SCORE: 0.727

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.C1548R	TCGA-06-1802	GBM	TCGA	PPTTPCST	DEG_SCF_FBW7_1	0.25
p.C1548R	DO12100	GBM	ICGC	PPTTPCST	DEG_SCF_FBW7_1	0.25
p.D1551V	TCGA-G3-A5SL	LIHC	TCGA	PPTTPCST	DEG_SCF_FBW7_1	0.1667
p.D1551V	DO44978	LIHC	ICGC	PPTTPCST	DEG_SCF_FBW7_1	0.1667
p.T1541M	TCGA-HU-A4H2	STAD	TCGA	PPTTPCST	DEG_SCF_FBW7_1	0.7423
p.T1541M	DO47825	STAD	ICGC	PPTTPCST	DEG_SCF_FBW7_1	0.7423
p.T1541M	SIDM00151	Ovarian Carcinoma	GDSC	PPTTPCST	DEG_SCF_FBW7_1	0.7423
p.T1541M	ACH-000966	Ovarian Cancer	CCLE	PPTTPCST	DEG_SCF_FBW7_1	0.7423
p.T1541M	IGROV-1	ovary	COSMIC	PPTTPCST	DEG_SCF_FBW7_1	0.7423
p.R1534G	TCGA-LP-A5U2	CESC	TCGA	PPTTPCST	DEG_SCF_FBW7_1	0.2222
p.R1534G	DO51610	CESC	ICGC	PPTTPCST	DEG_SCF_FBW7_1	0.2222
p.R1534G	SIDM01112	Osteosarcoma	GDSC	PPTTPCST	DEG_SCF_FBW7_1	0.2222
p.R1534G	ACH-000748	Bone Cancer	CCLE	PPTTPCST	DEG_SCF_FBW7_1	0.2222
p.R1534G	SJSA-1	bone	COSMIC	PPTTPCST	DEG_SCF_FBW7_1	0.2222
p.A1537V	DO233652	GACA	ICGC	PPTTPCST	DEG_SCF_FBW7_1	0.3056
p.V1547L	DO218554	ORCA	ICGC	PPTTPCST	DEG_SCF_FBW7_1	0.2778
p.T1540A	DO229470	SKCA	ICGC	PPTTPCST	DEG_SCF_FBW7_1	0.6028
p.C1548F	SIDM00589	Oral Cavity Carcinoma	GDSC	PPTTPCST	DEG_SCF_FBW7_1	0.25
p.C1548F	HSC-3	upper_aerodigestive_tract	COSMIC	PPTTPCST	DEG_SCF_FBW7_1	0.25
p.T1540M	SIDM00235	Kidney Carcinoma	GDSC	PPTTPCST	DEG_SCF_FBW7_1	0.6312
p.T1540M	SIDM00579	Neuroblastoma	GDSC	PPTTPCST	DEG_SCF_FBW7_1	0.6312
p.T1540M	SIDM00302	Other Solid Cancers	GDSC	PPTTPCST	DEG_SCF_FBW7_1	0.6312
p.T1540M	SIDM01781	Gastric Carcinoma	GDSC	PPTTPCST	DEG_SCF_FBW7_1	0.6312
p.T1540M	SIDM01574	Plasma Cell Myeloma	GDSC	PPTTPCST	DEG_SCF_FBW7_1	0.6312
p.T1540M	NB(TU)1-10	autonomic_ganglia	COSMIC	PPTTPCST	DEG_SCF_FBW7_1	0.6312
p.T1540M	RCC10RGB	kidney	COSMIC	PPTTPCST	DEG_SCF_FBW7_1	0.6312
p.T1540M	KGN	ovary	COSMIC	PPTTPCST	DEG_SCF_FBW7_1	0.6312

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75197	Low-density lipoprotein receptor-related protein 5	DEG_SCF_FBW7_1	1538:1545	PPTTPCST	FBXW7	0.9143	More...
O75581	Low-density lipoprotein receptor-related protein 6	DEG_SCF_FBW7_1	1527:1534	PPTTPCST	FBXW7	0.998	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PPTTPCST

Degron related mutations and impact score

Drug responses associated with LRP5 mutations

All proteins holding degron of PPTTPCST