DegronMD - O75197(LRP5)

GO - Biological processes (BP): adipose tissue development [GO:0060612]; anatomical structure regression [GO:0060033]; anterior/posterior pattern specification [GO:0009952]; apoptotic process involved in blood vessel morphogenesis [GO:1902262]; bone marrow development [GO:0048539]; bone morphogenesis [GO:0060349]; bone remodeling [GO:0046849]; branching involved in mammary gland duct morphogenesis [GO:0060444]; canonical Wnt signaling pathway [GO:0060070]; cell-cell signaling involved in mammary gland development [GO:0060764]; cell migration involved in gastrulation [GO:0042074]; cholesterol homeostasis [GO:0042632]; cholesterol metabolic process [GO:0008203]; embryonic digit morphogenesis [GO:0042733]; endocytosis [GO:0006897]; extracellular matrix-cell signaling [GO:0035426]; gastrulation with mouth forming second [GO:0001702]; glucose catabolic process [GO:0006007]; negative regulation of osteoblast differentiation [GO:0045668]; negative regulation of protein serine/threonine kinase activity [GO:0071901]; Norrin signaling pathway [GO:0110135]; osteoblast development [GO:0002076]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of DNA-binding transcription factor activity [GO:0051091]; positive regulation of fat cell differentiation [GO:0045600]; positive regulation of mesenchymal cell proliferation [GO:0002053]; positive regulation of mitotic nuclear division [GO:0045840]; positive regulation of osteoblast differentiation [GO:0045669]; positive regulation of osteoblast proliferation [GO:0033690]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; regulation of apoptotic process [GO:0042981]; regulation of blood pressure [GO:0008217]; regulation of insulin secretion involved in cellular response to glucose stimulus [GO:0061178]; retinal blood vessel morphogenesis [GO:0061304]; retina morphogenesis in camera-type eye [GO:0060042]; somatic stem cell population maintenance [GO:0035019] View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.C1548R	TCGA-06-1802	GBM	TCGA	PPTTPCST	DEG_SCF_FBW7_1	1538:1545	Mutation rewiring degron network	0.25
p.C1548R	DO12100	GBM	ICGC	PPTTPCST	DEG_SCF_FBW7_1	1538:1545	Mutation rewiring degron network	0.25
p.V1478I	TCGA-67-3771	LUAD	TCGA	ASSSS	DEG_SPOP_SBC_1	1481:1485	Mutation rewiring degron network	0.25
p.V1478I	DO25797	LUAD	ICGC	ASSSS	DEG_SPOP_SBC_1	1481:1485	Mutation rewiring degron network	0.25
p.R1475W	TCGA-CV-7568	HNSC	TCGA	ASSSS	DEG_SPOP_SBC_1	1481:1485	Mutation rewiring degron network	0.1667
p.R1475W	DO14160	HNSC	ICGC	ASSSS	DEG_SPOP_SBC_1	1481:1485	Mutation rewiring degron network	0.1667
p.D1551V	TCGA-G3-A5SL	LIHC	TCGA	PPTTPCST	DEG_SCF_FBW7_1	1538:1545	Mutation rewiring degron network	0.1667
p.D1551V	DO44978	LIHC	ICGC	PPTTPCST	DEG_SCF_FBW7_1	1538:1545	Mutation rewiring degron network	0.1667
p.R1475Q	TCGA-GN-A266	SKCM	TCGA	ASSSS	DEG_SPOP_SBC_1	1481:1485	Mutation rewiring degron network	0.1667
p.R1475Q	DO37432	SKCM	ICGC	ASSSS	DEG_SPOP_SBC_1	1481:1485	Mutation rewiring degron network	0.1667
p.T1541M	TCGA-HU-A4H2	STAD	TCGA	PPTTPCST	DEG_SCF_FBW7_1	1538:1545	Mutation altering degron motif	0.7423
p.T1541M	DO47825	STAD	ICGC	PPTTPCST	DEG_SCF_FBW7_1	1538:1545	Mutation altering degron motif	0.7423
p.T1541M	SIDM00151	Ovarian Carcinoma	GDSC	PPTTPCST	DEG_SCF_FBW7_1	1538:1545	Mutation altering degron motif	0.7423
p.T1541M	ACH-000966	Ovarian Cancer	CCLE	PPTTPCST	DEG_SCF_FBW7_1	1538:1545	Mutation altering degron motif	0.7423
p.T1541M	IGROV-1	ovary	COSMIC	PPTTPCST	DEG_SCF_FBW7_1	1538:1545	Mutation altering degron motif	0.7423
p.R1534G	TCGA-LP-A5U2	CESC	TCGA	PPTTPCST	DEG_SCF_FBW7_1	1538:1545	Mutation rewiring degron network	0.2222
p.R1534G	DO51610	CESC	ICGC	PPTTPCST	DEG_SCF_FBW7_1	1538:1545	Mutation rewiring degron network	0.2222
p.R1534G	SIDM01112	Osteosarcoma	GDSC	PPTTPCST	DEG_SCF_FBW7_1	1538:1545	Mutation rewiring degron network	0.2222
p.R1534G	ACH-000748	Bone Cancer	CCLE	PPTTPCST	DEG_SCF_FBW7_1	1538:1545	Mutation rewiring degron network	0.2222
p.R1534G	SJSA-1	bone	COSMIC	PPTTPCST	DEG_SCF_FBW7_1	1538:1545	Mutation rewiring degron network	0.2222
p.A1537V	DO233652	GACA	ICGC	PPTTPCST	DEG_SCF_FBW7_1	1538:1545	Mutation rewiring degron network	0.3056
p.V1547L	DO218554	ORCA	ICGC	PPTTPCST	DEG_SCF_FBW7_1	1538:1545	Mutation rewiring degron network	0.2778
p.T1540A	DO229470	SKCA	ICGC	PPTTPCST	DEG_SCF_FBW7_1	1538:1545	Mutation altering degron motif	0.6028
p.Y1494S	DO229167	THCA	ICGC	ASSSS	DEG_SPOP_SBC_1	1481:1485	Mutation blocking phosphorylation signal	0.5278
p.Y1494S	DO229180	THCA	ICGC	ASSSS	DEG_SPOP_SBC_1	1481:1485	Mutation blocking phosphorylation signal	0.5278
p.Y1494S	DO229191	THCA	ICGC	ASSSS	DEG_SPOP_SBC_1	1481:1485	Mutation blocking phosphorylation signal	0.5278
p.Y1494S	DO229211	THCA	ICGC	ASSSS	DEG_SPOP_SBC_1	1481:1485	Mutation blocking phosphorylation signal	0.5278
p.S1482T	DO229242	THCA	ICGC	ASSSS	DEG_SPOP_SBC_1	1481:1485	Mutation altering degron motif	0.6005
p.C1548F	SIDM00589	Oral Cavity Carcinoma	GDSC	PPTTPCST	DEG_SCF_FBW7_1	1538:1545	Mutation rewiring degron network	0.25
p.C1548F	HSC-3	upper aerodigestive tract	COSMIC	PPTTPCST	DEG_SCF_FBW7_1	1538:1545	Mutation rewiring degron network	0.25
p.T1540M	SIDM00235	Kidney Carcinoma	GDSC	PPTTPCST	DEG_SCF_FBW7_1	1538:1545	Mutation altering degron motif	0.6312
p.T1540M	SIDM00579	Neuroblastoma	GDSC	PPTTPCST	DEG_SCF_FBW7_1	1538:1545	Mutation altering degron motif	0.6312
p.T1540M	SIDM00302	Other Solid Cancers	GDSC	PPTTPCST	DEG_SCF_FBW7_1	1538:1545	Mutation altering degron motif	0.6312
p.T1540M	SIDM01781	Gastric Carcinoma	GDSC	PPTTPCST	DEG_SCF_FBW7_1	1538:1545	Mutation altering degron motif	0.6312
p.T1540M	SIDM01574	Plasma Cell Myeloma	GDSC	PPTTPCST	DEG_SCF_FBW7_1	1538:1545	Mutation altering degron motif	0.6312
p.T1540M	NB(TU)1-10	autonomic ganglia	COSMIC	PPTTPCST	DEG_SCF_FBW7_1	1538:1545	Mutation altering degron motif	0.6312
p.T1540M	RCC10RGB	kidney	COSMIC	PPTTPCST	DEG_SCF_FBW7_1	1538:1545	Mutation altering degron motif	0.6312
p.T1540M	KGN	ovary	COSMIC	PPTTPCST	DEG_SCF_FBW7_1	1538:1545	Mutation altering degron motif	0.6312
p.P1495L	ACH-000837	Lung Cancer	CCLE	ASSSS	DEG_SPOP_SBC_1	1481:1485	Mutation rewiring degron network	0.0556

Kaplan plot for LRP5 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

LRP5

UniProt ID: O75197

Entrez ID: 4041

Protein name: Low-density lipoprotein receptor-related protein 5 (LRP-5) (Low-density lipoprotein receptor-related protein 7) (LRP-7)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for LRP5 in