DegronMD - Q5TCX8(MAP3K21)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V1004M	SIDM00282	Colorectal Carcinoma	GDSC	ERTKSHVPSL	DEG_COP1_1	990:999	Mutation rewiring degron network	0.1944
p.V1004M	SIDM00687	Gastric Carcinoma	GDSC	ERTKSHVPSL	DEG_COP1_1	990:999	Mutation rewiring degron network	0.1944
p.V1004M	SIDM00574	Glioblastoma	GDSC	ERTKSHVPSL	DEG_COP1_1	990:999	Mutation rewiring degron network	0.1944
p.V1004M	SIDM00368	Small Cell Lung Carcinoma	GDSC	ERTKSHVPSL	DEG_COP1_1	990:999	Mutation rewiring degron network	0.1944
p.V1004M	SIDM00243	Other Solid Cancers	GDSC	ERTKSHVPSL	DEG_COP1_1	990:999	Mutation rewiring degron network	0.1944
p.V1004M	CW-2	large intestine	COSMIC	ERTKSHVPSL	DEG_COP1_1	990:999	Mutation rewiring degron network	0.1944
p.V1004M	NEC8	testis	COSMIC	ERTKSHVPSL	DEG_COP1_1	990:999	Mutation rewiring degron network	0.1944
p.V1004M	KATOIII	stomach	COSMIC	ERTKSHVPSL	DEG_COP1_1	990:999	Mutation rewiring degron network	0.1944
p.V1004M	SBC-5	lung	COSMIC	ERTKSHVPSL	DEG_COP1_1	990:999	Mutation rewiring degron network	0.1944
p.V1004M	no-10	central nervous system	COSMIC	ERTKSHVPSL	DEG_COP1_1	990:999	Mutation rewiring degron network	0.1944
p.F985L	SIDM00874	Breast Carcinoma	GDSC	ERTKSHVPSL	DEG_COP1_1	990:999	Mutation rewiring degron network	0.1944
p.F985L	HCC1937	breast	COSMIC	ERTKSHVPSL	DEG_COP1_1	990:999	Mutation rewiring degron network	0.1944
p.A695V	SIDM01180	Hepatocellular Carcinoma	GDSC	IEMTPTNS	DEG_SCF_FBW7_1	702:709	Mutation rewiring degron network	0.1389
p.A695V	SIDM00252	Biliary Tract Carcinoma	GDSC	IEMTPTNS	DEG_SCF_FBW7_1	702:709	Mutation rewiring degron network	0.1389
p.A695V	SIDM00655	Other Solid Cancers	GDSC	IEMTPTNS	DEG_SCF_FBW7_1	702:709	Mutation rewiring degron network	0.1389
p.A695V	TGBC1TKB	biliary tract	COSMIC	IEMTPTNS	DEG_SCF_FBW7_1	702:709	Mutation rewiring degron network	0.1389
p.A695V	NCCIT	testis	COSMIC	IEMTPTNS	DEG_SCF_FBW7_1	702:709	Mutation rewiring degron network	0.1389
p.A695V	SNU-387	liver	COSMIC	IEMTPTNS	DEG_SCF_FBW7_1	702:709	Mutation rewiring degron network	0.1389
p.S713F	SIDM00045	Gastric Carcinoma	GDSC	IEMTPTNS	DEG_SCF_FBW7_1	702:709	Mutation rewiring degron network	0.2222
p.S713F	HSC-39	stomach	COSMIC	IEMTPTNS	DEG_SCF_FBW7_1	702:709	Mutation rewiring degron network	0.2222
p.I801T	SIDM01724	Melanoma	GDSC	ILSTPSFS	DEG_SCF_FBW7_1	801:808	Mutation altering degron motif	0.7078
p.L986F	SIDM01768	Melanoma	GDSC	ERTKSHVPSL	DEG_COP1_1	990:999	Mutation rewiring degron network	0.2222

Kaplan plot for MAP3K21 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MAP3K21

UniProt ID: Q5TCX8

Entrez ID: 84451

Protein name: Mitogen-activated protein kinase kinase kinase 21 (EC 2.7.11.25) (Mitogen-activated protein kinase kinase kinase MLK4) (Mixed lineage kinase 4)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MAP3K21 in