DegronMD

Uniprot ID: Q5TCX8

Source protein: Mitogen-activated protein kinase kinase kinase 21

Source gene: MAP3K21

Class: DEG_SCF_FBW7_1

Location: 801:808

E3 ligase: FBXW7

DEGRON score: 0.8764

ASA_SCORE: 61.2875

COIL: 0.7841

CONS_SCORE: 0.1956

DSS_SCORE: 0.285

HELIX: 0.0933

FCONS_SCORE: 0.7356

RIG_SCORE: 0.7246

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I801T	SIDM01724	Melanoma	GDSC	ILSTPSFS	DEG_SCF_FBW7_1	0.7078

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5TCX8	Mitogen-activated protein kinase kinase kinase 21	DEG_SCF_FBW7_1	801:808	ILSTPSFS	FBXW7	0.8764	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons