DegronMD

Uniprot ID: Q5TCX8

Source protein: Mitogen-activated protein kinase kinase kinase 21

Source gene: MAP3K21

Class: DEG_SCF_FBW7_1

Location: 702:709

E3 ligase: FBXW7

DEGRON score: 0.9731

ASA_SCORE: 82.6875

COIL: 0.8658

CONS_SCORE: 0.2804

DSS_SCORE: 0.5485

HELIX: 0.0989

FCONS_SCORE: 1.0454

RIG_SCORE: 0.713

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A695V	SIDM01180	Hepatocellular Carcinoma	GDSC	IEMTPTNS	DEG_SCF_FBW7_1	0.1389
p.A695V	SIDM00252	Biliary Tract Carcinoma	GDSC	IEMTPTNS	DEG_SCF_FBW7_1	0.1389
p.A695V	SIDM00655	Other Solid Cancers	GDSC	IEMTPTNS	DEG_SCF_FBW7_1	0.1389
p.A695V	TGBC1TKB	biliary_tract	COSMIC	IEMTPTNS	DEG_SCF_FBW7_1	0.1389
p.A695V	NCCIT	testis	COSMIC	IEMTPTNS	DEG_SCF_FBW7_1	0.1389
p.A695V	SNU-387	liver	COSMIC	IEMTPTNS	DEG_SCF_FBW7_1	0.1389
p.S713F	SIDM00045	Gastric Carcinoma	GDSC	IEMTPTNS	DEG_SCF_FBW7_1	0.2222
p.S713F	HSC-39	stomach	COSMIC	IEMTPTNS	DEG_SCF_FBW7_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5TCX8	Mitogen-activated protein kinase kinase kinase 21	DEG_SCF_FBW7_1	702:709	IEMTPTNS	FBXW7	0.9731	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons