DegronMD

Uniprot ID: Q5TCX8

Source protein: Mitogen-activated protein kinase kinase kinase 21

Source gene: MAP3K21

Class: DEG_COP1_1

Location: 990:999

E3 ligase: COP1

DEGRON score: 0.7257

ASA_SCORE: 88.94

COIL: 0.7788

CONS_SCORE: 0.2518

DSS_SCORE: 0.4973

HELIX: 0.1605

FCONS_SCORE: 1.0154

RIG_SCORE: 0.7139

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V1004M	SIDM00282	Colorectal Carcinoma	GDSC	ERTKSHVPSL	DEG_COP1_1	0.1944
p.V1004M	SIDM00687	Gastric Carcinoma	GDSC	ERTKSHVPSL	DEG_COP1_1	0.1944
p.V1004M	SIDM00574	Glioblastoma	GDSC	ERTKSHVPSL	DEG_COP1_1	0.1944
p.V1004M	SIDM00368	Small Cell Lung Carcinoma	GDSC	ERTKSHVPSL	DEG_COP1_1	0.1944
p.V1004M	SIDM00243	Other Solid Cancers	GDSC	ERTKSHVPSL	DEG_COP1_1	0.1944
p.V1004M	CW-2	large_intestine	COSMIC	ERTKSHVPSL	DEG_COP1_1	0.1944
p.V1004M	NEC8	testis	COSMIC	ERTKSHVPSL	DEG_COP1_1	0.1944
p.V1004M	KATOIII	stomach	COSMIC	ERTKSHVPSL	DEG_COP1_1	0.1944
p.V1004M	SBC-5	lung	COSMIC	ERTKSHVPSL	DEG_COP1_1	0.1944
p.V1004M	no-10	central_nervous_system	COSMIC	ERTKSHVPSL	DEG_COP1_1	0.1944
p.F985L	SIDM00874	Breast Carcinoma	GDSC	ERTKSHVPSL	DEG_COP1_1	0.1944
p.F985L	HCC1937	breast	COSMIC	ERTKSHVPSL	DEG_COP1_1	0.1944
p.L986F	SIDM01768	Melanoma	GDSC	ERTKSHVPSL	DEG_COP1_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5TCX8	Mitogen-activated protein kinase kinase kinase 21	DEG_COP1_1	990:999	ERTKSHVPSL	COP1	0.7257	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons