DegronMD

Uniprot ID: P25440

Source protein: Bromodomain-containing protein 2

Source gene: BRD2

Class: DEG_SPOP_SBC_1

Location: 776:780

E3 ligase: SPOP

DEGRON score: 0.9929

ASA_SCORE: 97.7

COIL: 0.9572

CONS_SCORE: 0.3767

DSS_SCORE: 0.5375

HELIX: 0.0332

FCONS_SCORE: 0.9929

RIG_SCORE: 0.5021

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E770G	TCGA-13-1477	OV	TCGA	ASSSS	DEG_SPOP_SBC_1	0.1667
p.E770G	DO27978	OV	ICGC	ASSSS	DEG_SPOP_SBC_1	0.1667
p.K773N	TCGA-AJ-A3BH	UCEC	TCGA	ASSSS	DEG_SPOP_SBC_1	0.25
p.K773N	DO41638	UCEC	ICGC	ASSSS	DEG_SPOP_SBC_1	0.25
p.R774Q	TCGA-BR-4362	STAD	TCGA	ASSSS	DEG_SPOP_SBC_1	0.2778
p.R774Q	DO38336	STAD	ICGC	ASSSS	DEG_SPOP_SBC_1	0.2778
p.N783S	TCGA-E9-A3QA	BRCA	TCGA	ASSSS	DEG_SPOP_SBC_1	0.25
p.N783S	TCGA-XF-A8HG	BLCA	TCGA	ASSSS	DEG_SPOP_SBC_1	0.25
p.N783S	DO49802	BLCA	ICGC	ASSSS	DEG_SPOP_SBC_1	0.25
p.N783S	DO44268	BRCA	ICGC	ASSSS	DEG_SPOP_SBC_1	0.25
p.N783S	SIDM00661	B-Cell Non-Hodgkin's Lymphoma	GDSC	ASSSS	DEG_SPOP_SBC_1	0.25
p.N783S	ACH-000914	Lymphoma	CCLE	ASSSS	DEG_SPOP_SBC_1	0.25
p.N783S	HT	haematopoietic_and_lymphoid_tissue	COSMIC	ASSSS	DEG_SPOP_SBC_1	0.25
p.P789L	TCGA-WE-A8ZX	SKCM	TCGA	ASSSS	DEG_SPOP_SBC_1	0.5278
p.P789L	DO51291	SKCM	ICGC	ASSSS	DEG_SPOP_SBC_1	0.5278
p.L774F	DO233902	GACA	ICGC	ASSSS	DEG_SPOP_SBC_1	0.2778
p.T785S	DO233909	GACA	ICGC	ASSSS	DEG_SPOP_SBC_1	0.6389
p.E770K	DO52686	MALY	ICGC	ASSSS	DEG_SPOP_SBC_1	0.1667
p.R769Q	ACH-002061	Leukemia	CCLE	ASSSS	DEG_SPOP_SBC_1	0.1389

Drug responses associated with BRD2 mutations

Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
SIDM00526	LCML\|chronic_myeloid_leukaemia	p.N429S (No)	GDSC	JQ1	0.338
SIDM00526	LCML\|chronic_myeloid_leukaemia	p.N429S (No)	GDSC	I-BET-762	2.9946
SIDM00526	LCML\|chronic_myeloid_leukaemia	p.N429S (No)	GDSC	JQ1	0.3785
SIDM00526	LCML\|chronic_myeloid_leukaemia	p.N429S (No)	GDSC	I-BET-762	2.1256
SIDM00526	LCML\|chronic_myeloid_leukaemia	p.N429S (No)	GDSC	OTX015	0.4581
SIDM01045	UCEC\|endometrium	p.K755fs*5 (No)	GDSC	JQ1	42.7375
SIDM01045	UCEC\|endometrium	p.K755fs*5 (No)	GDSC	I-BET-762	252.4732
SIDM01045	UCEC\|endometrium	p.K755fs*5 (No)	GDSC	JQ1	21.9324
SIDM01045	UCEC\|endometrium	p.K755fs*5 (No)	GDSC	I-BET-762	106.84
SIDM01045	UCEC\|endometrium	p.K755fs*5 (No)	GDSC	OTX015	78.131
SIDM00661	DLBC\|B_cell_lymphoma	p.N748S (No)	GDSC	JQ1	1.2088
SIDM00661	DLBC\|B_cell_lymphoma	p.N748S (No)	GDSC	I-BET-762	2.6133
SIDM00661	DLBC\|B_cell_lymphoma	p.N748S (No)	GDSC	JQ1	0.8621
SIDM00997	THCA\|thyroid	p.E14G (No)	GDSC	JQ1	0.2229
SIDM00997	THCA\|thyroid	p.E14G (No)	GDSC	I-BET-762	433.4615
SIDM00997	THCA\|thyroid	p.E14G (No)	GDSC	JQ1	12.6634
SIDM00997	THCA\|thyroid	p.E14G (No)	GDSC	I-BET-762	18.887
SIDM00997	THCA\|thyroid	p.E14G (No)	GDSC	OTX015	2.9339
SIDM00859	DLBC\|B_cell_lymphoma	p.F149S (No)	GDSC	JQ1	1.0416
SIDM00859	DLBC\|B_cell_lymphoma	p.F149S (No)	GDSC	I-BET-762	25.1531
SIDM00859	DLBC\|B_cell_lymphoma	p.F149S (No)	GDSC	JQ1	2.8509
SIDM00859	DLBC\|B_cell_lymphoma	p.F149S (No)	GDSC	I-BET-762	36.989
SIDM00859	DLBC\|B_cell_lymphoma	p.F149S (No)	GDSC	OTX015	18.225
SIDM00781	COREAD\|large_intestine	p.A292T (No)	GDSC	JQ1	1.035
SIDM00781	COREAD\|large_intestine	p.A292T (No)	GDSC	I-BET-762	11.5453
SIDM00781	COREAD\|large_intestine	p.A292T (No)	GDSC	JQ1	21.0914
SIDM00781	COREAD\|large_intestine	p.A292T (No)	GDSC	I-BET-762	22.924
SIDM00781	COREAD\|large_intestine	p.A292T (No)	GDSC	OTX015	3.8966
SIDM00719	SCLC\|lung_small_cell_carcinoma	p.T629A (No)	GDSC	JQ1	78.9202
SIDM00719	SCLC\|lung_small_cell_carcinoma	p.T629A (No)	GDSC	I-BET-762	220.0569
SIDM00719	SCLC\|lung_small_cell_carcinoma	p.T629A (No)	GDSC	JQ1	31.3189
SIDM00719	SCLC\|lung_small_cell_carcinoma	p.T629A (No)	GDSC	I-BET-762	245.98
SIDM00719	SCLC\|lung_small_cell_carcinoma	p.T629A (No)	GDSC	OTX015	271.2
SIDM00318	KIRC\|kidney	p.A766T (Yes)	GDSC	JQ1	0.4368
SIDM00318	KIRC\|kidney	p.A766T (Yes)	GDSC	I-BET-762	156.5988
SIDM00958	LCML\|chronic_myeloid_leukaemia	p.A17V (No)	GDSC	JQ1	1.7031
SIDM00958	LCML\|chronic_myeloid_leukaemia	p.A17V (No)	GDSC	I-BET-762	9.0749
SIDM00958	LCML\|chronic_myeloid_leukaemia	p.A17V (No)	GDSC	OTX015	6.8733
SIDM00151	OV\|ovary	p.F145fs*20 (No)	GDSC	JQ1	22.7238
SIDM00151	OV\|ovary	p.F145fs*20 (No)	GDSC	I-BET-762	9.7528
SIDM00151	OV\|ovary	p.F145fs*20 (No)	GDSC	OTX015	3.6257
SIDM00044	HNSC\|head_and_neck	p.A766T (Yes)	GDSC	JQ1	43.1291
SIDM00044	HNSC\|head_and_neck	p.A766T (Yes)	GDSC	I-BET-762	370.1414
SIDM00044	HNSC\|head_and_neck	p.A766T (Yes)	GDSC	JQ1	19.9746
SIDM00251	STAD\|stomach	p.P471fs*50 (No)	GDSC	JQ1	6.3107
SIDM00251	STAD\|stomach	p.P471fs*50 (No)	GDSC	I-BET-762	105.237
SIDM00251	STAD\|stomach	p.P471fs*50 (No)	GDSC	JQ1	4.1863
SIDM00946	ALL\|T_cell_leukemia	p.T190A (No)	GDSC	JQ1	0.2744
SIDM00946	ALL\|T_cell_leukemia	p.T190A (No)	GDSC	I-BET-762	1.0054
SIDM00946	ALL\|T_cell_leukemia	p.T190A (No)	GDSC	JQ1	7.1926
SIDM00946	ALL\|T_cell_leukemia	p.T190A (No)	GDSC	I-BET-762	7.8467
SIDM00946	ALL\|T_cell_leukemia	p.T190A (No)	GDSC	OTX015	7.885
SIDM00689	DLBC\|B_cell_lymphoma	p.W136* (No)	GDSC	JQ1	0.4375
SIDM00689	DLBC\|B_cell_lymphoma	p.W136* (No)	GDSC	I-BET-762	2.1987
SIDM00689	DLBC\|B_cell_lymphoma	p.W136* (No)	GDSC	JQ1	4.4174
SIDM00933	BRCA\|breast	p.A619T (No)	GDSC	JQ1	3.4367
SIDM00933	BRCA\|breast	p.A619T (No)	GDSC	I-BET-762	114.2188
SIDM00933	BRCA\|breast	p.A619T (No)	GDSC	JQ1	4.869
SIDM00933	BRCA\|breast	p.A619T (No)	GDSC	I-BET-762	260.84
SIDM00933	BRCA\|breast	p.A619T (No)	GDSC	OTX015	42.102
SIDM00933	BRCA\|breast	p.A619T (No)	GDSC	JQ1	40.792
SIDM00082	SKCM\|melanoma	p.A766T (Yes)	GDSC	JQ1	2.6614
SIDM00082	SKCM\|melanoma	p.A766T (Yes)	GDSC	I-BET-762	287.9299
SIDM00082	SKCM\|melanoma	p.A766T (Yes)	GDSC	JQ1	9.75
SIDM00082	SKCM\|melanoma	p.A766T (Yes)	GDSC	I-BET-762	85.054
SIDM00082	SKCM\|melanoma	p.A766T (Yes)	GDSC	OTX015	116.85
SIDM01047	LCML\|chronic_myeloid_leukaemia	p.P192S (No)	GDSC	JQ1	0.9507
SIDM01047	LCML\|chronic_myeloid_leukaemia	p.P192S (No)	GDSC	I-BET-762	5.5114
SIDM01047	LCML\|chronic_myeloid_leukaemia	p.P192S (No)	GDSC	JQ1	0.3938
SIDM01047	LCML\|chronic_myeloid_leukaemia	p.P192S (No)	GDSC	I-BET-762	2.9656
SIDM01047	LCML\|chronic_myeloid_leukaemia	p.P192S (No)	GDSC	OTX015	0.6297
SIDM01141	OV\|ovary	p.A766T (Yes)	GDSC	JQ1	1.5933
SIDM01141	OV\|ovary	p.A766T (Yes)	GDSC	I-BET-762	49.8631
SIDM01141	OV\|ovary	p.A766T (Yes)	GDSC	JQ1	15.1653
SIDM01141	OV\|ovary	p.A766T (Yes)	GDSC	I-BET-762	54.558
SIDM01141	OV\|ovary	p.A766T (Yes)	GDSC	OTX015	21.698
SIDM00216	COREAD\|large_intestine	p.E522G (No)	GDSC	I-BET-762	2.1779
SIDM00216	COREAD\|large_intestine	p.E522G (No)	GDSC	I-BET-762	6.6864
SIDM00216	COREAD\|large_intestine	p.E522G (No)	GDSC	OTX015	5.0449
SIDM01186	BRCA\|breast	p.E513fs*19 (No)	GDSC	JQ1	2.5778
SIDM01186	BRCA\|breast	p.E513fs*19 (No)	GDSC	I-BET-762	149.0211
SIDM01186	BRCA\|breast	p.E513fs*19 (No)	GDSC	JQ1	18.9828
SIDM01186	BRCA\|breast	p.E513fs*19 (No)	GDSC	JQ1	39.022
SIDM01085	BLCA\|bladder	p.P58H (No)	GDSC	JQ1	2.5551
SIDM01085	BLCA\|bladder	p.P58H (No)	GDSC	I-BET-762	53.3819
SIDM01085	BLCA\|bladder	p.P58H (No)	GDSC	JQ1	13.5696
SIDM01085	BLCA\|bladder	p.P58H (No)	GDSC	I-BET-762	58.836
SIDM01085	BLCA\|bladder	p.P58H (No)	GDSC	OTX015	29.1
SIDM00596	UCEC\|endometrium	p.P658H (No)	GDSC	JQ1	0.641
SIDM00596	UCEC\|endometrium	p.P658H (No)	GDSC	I-BET-762	201.9926
SIDM00596	UCEC\|endometrium	p.P658H (No)	GDSC	JQ1	9.0853
SIDM00596	UCEC\|endometrium	p.P658H (No)	GDSC	I-BET-762	19.258
SIDM00596	UCEC\|endometrium	p.P658H (No)	GDSC	OTX015	5.1627
SIDM00699	SCLC\|lung_small_cell_carcinoma	p.E14G (No)	GDSC	JQ1	6.0137
SIDM00699	SCLC\|lung_small_cell_carcinoma	p.E14G (No)	GDSC	I-BET-762	62.1037
SIDM00699	SCLC\|lung_small_cell_carcinoma	p.E14G (No)	GDSC	JQ1	12.8765
SIDM00699	SCLC\|lung_small_cell_carcinoma	p.E14G (No)	GDSC	I-BET-762	133.6
SIDM00699	SCLC\|lung_small_cell_carcinoma	p.E14G (No)	GDSC	OTX015	224.7
SIDM00660	COREAD\|large_intestine	p.T210S (No)	GDSC	JQ1	0.1746
SIDM00660	COREAD\|large_intestine	p.T210S (No)	GDSC	I-BET-762	3.4801
SIDM00660	COREAD\|large_intestine	p.T210S (No)	GDSC	JQ1	15.9176
SIDM00660	COREAD\|large_intestine	p.T210S (No)	GDSC	I-BET-762	13.313
SIDM00660	COREAD\|large_intestine	p.T210S (No)	GDSC	OTX015	7.248
SIDM01147	STAD\|stomach	p.H83Q (No)	GDSC	JQ1	24.9041
SIDM01147	STAD\|stomach	p.H83Q (No)	GDSC	I-BET-762	11.04
SIDM01147	STAD\|stomach	p.H83Q (No)	GDSC	OTX015	8.5555
SIDM00973	SKCM\|melanoma	p.A766T (Yes)	GDSC	JQ1	0.1875
SIDM00973	SKCM\|melanoma	p.A766T (Yes)	GDSC	I-BET-762	10.9899
SIDM00973	SKCM\|melanoma	p.A766T (Yes)	GDSC	JQ1	11.8757
SIDM00973	SKCM\|melanoma	p.A766T (Yes)	GDSC	I-BET-762	15.191
SIDM00973	SKCM\|melanoma	p.A766T (Yes)	GDSC	OTX015	22.167
SIDM00238	OV\|ovary	p.E506_S507insE (No)	GDSC	I-BET-762	314.0424
SIDM00238	OV\|ovary	p.E506_S507insE (No)	GDSC	JQ1	14.1477
SIDM00238	OV\|ovary	p.E506_S507insE (No)	GDSC	I-BET-762	218.79
SIDM00238	OV\|ovary	p.E506_S507insE (No)	GDSC	OTX015	100.87
SIDM01067	LUAD\|lung_NSCLC_adenocarcinoma	p.A766T (Yes)	GDSC	JQ1	7.4871
SIDM01067	LUAD\|lung_NSCLC_adenocarcinoma	p.A766T (Yes)	GDSC	I-BET-762	608.9262
SIDM01067	LUAD\|lung_NSCLC_adenocarcinoma	p.A766T (Yes)	GDSC	JQ1	6.2721
SIDM01067	LUAD\|lung_NSCLC_adenocarcinoma	p.A766T (Yes)	GDSC	I-BET-762	59.017
SIDM01067	LUAD\|lung_NSCLC_adenocarcinoma	p.A766T (Yes)	GDSC	OTX015	537.31
SIDM01261	BRCA\|breast	p.S7L (No)	GDSC	I-BET-762	97.6715
SIDM00120	PRAD\|prostate	p.R577M (No)	GDSC	JQ1	0.7323
SIDM00120	PRAD\|prostate	p.R577M (No)	GDSC	I-BET-762	286.8657
SIDM00120	PRAD\|prostate	p.R577M (No)	GDSC	JQ1	4.1512
SIDM00120	PRAD\|prostate	p.R577M (No)	GDSC	I-BET-762	298.43
SIDM00120	PRAD\|prostate	p.R577M (No)	GDSC	OTX015	55.349
SIDM00727	LUAD\|lung_NSCLC_adenocarcinoma	p.S256C (No)	GDSC	JQ1	0.3436
SIDM00727	LUAD\|lung_NSCLC_adenocarcinoma	p.S256C (No)	GDSC	I-BET-762	336.8312
SIDM00727	LUAD\|lung_NSCLC_adenocarcinoma	p.S256C (No)	GDSC	JQ1	13.1372
SIDM00407	DLBC\|B_cell_lymphoma	p.V177G (No)	GDSC	JQ1	0.2695
SIDM00407	DLBC\|B_cell_lymphoma	p.V177G (No)	GDSC	I-BET-762	1.3284
SIDM00407	DLBC\|B_cell_lymphoma	p.V177G (No)	GDSC	JQ1	0.7693
SIDM00407	DLBC\|B_cell_lymphoma	p.V177G (No)	GDSC	I-BET-762	2.5438
SIDM00407	DLBC\|B_cell_lymphoma	p.V177G (No)	GDSC	OTX015	0.5581
SIDM00934	PAAD\|pancreas	p.A766T (Yes)	GDSC	JQ1	2.5914
SIDM00934	PAAD\|pancreas	p.A766T (Yes)	GDSC	I-BET-762	46.4602
SIDM00934	PAAD\|pancreas	p.A766T (Yes)	GDSC	I-BET-762	157.94
SIDM00934	PAAD\|pancreas	p.A766T (Yes)	GDSC	OTX015	144.95
SIDM00726	LUAD\|lung_NSCLC_adenocarcinoma	p.P216S (No)	GDSC	JQ1	0.937
SIDM00726	LUAD\|lung_NSCLC_adenocarcinoma	p.P216S (No)	GDSC	I-BET-762	162.708
SIDM00726	LUAD\|lung_NSCLC_adenocarcinoma	p.P216S (No)	GDSC	JQ1	16.4233
SIDM00339	LUAD\|lung_NSCLC_adenocarcinoma	p.E660V (No)	GDSC	JQ1	0.7264
SIDM00339	LUAD\|lung_NSCLC_adenocarcinoma	p.E660V (No)	GDSC	I-BET-762	163.4619
SIDM00339	LUAD\|lung_NSCLC_adenocarcinoma	p.E660V (No)	GDSC	JQ1	3.1453
SIDM00339	LUAD\|lung_NSCLC_adenocarcinoma	p.E660V (No)	GDSC	I-BET-762	14.646
SIDM00339	LUAD\|lung_NSCLC_adenocarcinoma	p.E660V (No)	GDSC	OTX015	1.4241
SIDM00222	MESO\|mesothelioma	p.A766T (Yes)	GDSC	JQ1	5.6541
SIDM00222	MESO\|mesothelioma	p.A766T (Yes)	GDSC	I-BET-762	5.5699
SIDM00222	MESO\|mesothelioma	p.A766T (Yes)	GDSC	JQ1	19.0767
SIDM00222	MESO\|mesothelioma	p.A766T (Yes)	GDSC	I-BET-762	8.5939
SIDM00222	MESO\|mesothelioma	p.A766T (Yes)	GDSC	OTX015	6.3419
SIDM01259	ALL\|lymphoblastic_leukemia	p.R701C (No)	GDSC	JQ1	0.5022
SIDM01259	ALL\|lymphoblastic_leukemia	p.R701C (No)	GDSC	I-BET-762	1.8887
SIDM01259	ALL\|lymphoblastic_leukemia	p.R701C (No)	GDSC	JQ1	2.2668
SIDM01259	ALL\|lymphoblastic_leukemia	p.R701C (No)	GDSC	I-BET-762	4.003
SIDM01259	ALL\|lymphoblastic_leukemia	p.R701C (No)	GDSC	OTX015	1.1727
SIDM00875	UNCLASSIFIED\|breast	p.K756E (No)	GDSC	JQ1	2.7845
SIDM00875	UNCLASSIFIED\|breast	p.K756E (No)	GDSC	I-BET-762	71.8758
SIDM00875	UNCLASSIFIED\|breast	p.K756E (No)	GDSC	JQ1	8.9974
SIDM00875	UNCLASSIFIED\|breast	p.K756E (No)	GDSC	I-BET-762	17.667
SIDM00875	UNCLASSIFIED\|breast	p.K756E (No)	GDSC	OTX015	9.1906
SIDM00875	UNCLASSIFIED\|breast	p.K756E (No)	GDSC	JQ1	4.1871
SIDM00332	BRCA\|breast	p.D333Y (No)	GDSC	JQ1	44.9286
SIDM00332	BRCA\|breast	p.D333Y (No)	GDSC	I-BET-762	386.7378
SIDM00332	BRCA\|breast	p.D333Y (No)	GDSC	JQ1	15.3448
SIDM00332	BRCA\|breast	p.D333Y (No)	GDSC	I-BET-762	110.91
SIDM00332	BRCA\|breast	p.D333Y (No)	GDSC	OTX015	73.72
SIDM00332	BRCA\|breast	p.D333Y (No)	GDSC	JQ1	284.17
SIDM00086	KIRC\|kidney	p.A766T (Yes)	GDSC	JQ1	14.8159
SIDM00086	KIRC\|kidney	p.A766T (Yes)	GDSC	I-BET-762	515.8474
SIDM00086	KIRC\|kidney	p.A766T (Yes)	GDSC	JQ1	20.0699
SIDM00086	KIRC\|kidney	p.A766T (Yes)	GDSC	I-BET-762	169.69
SIDM00086	KIRC\|kidney	p.A766T (Yes)	GDSC	OTX015	127.47

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A0JLT2	Mediator of RNA polymerase II transcription subunit 19	DEG_SPOP_SBC_1	237:241	ASSSS	SPOP	0.692	More...
A2VDJ0	Transmembrane protein 131-like	DEG_SPOP_SBC_1	909:913	ASSSS	SPOP	0.7658	More...
A4D161	Protein FAM221A	DEG_SPOP_SBC_1	237:241	ASSSS	SPOP	0.9261	More...
O00571	ATP-dependent RNA helicase DDX3X	DEG_SPOP_SBC_1	608:612	ASSSS	SPOP	0.9984	More...
O14492	SH2B adapter protein 2	DEG_SPOP_SBC_1	566:570	ASSSS	SPOP	0.9979	More...
O14492	SH2B adapter protein 2	DEG_SPOP_SBC_1	571:575	ASSSS	SPOP	0.9977	More...
O14497	AT-rich interactive domain-containing protein 1A	DEG_SPOP_SBC_1	259:263	ASSSS	SPOP	0.8451	More...
O15018	PDZ domain-containing protein 2	DEG_SPOP_SBC_1	2168:2172	ASSSS	SPOP	0.9964	More...
O15047	Histone-lysine N-methyltransferase SETD1A	DEG_SPOP_SBC_1	339:343	ASSSS	SPOP	0.9582	More...
O15054	Lysine-specific demethylase 6B	DEG_SPOP_SBC_1	865:869	ASSSS	SPOP	0.9886	More...
O15265	Ataxin-7	DEG_SPOP_SBC_1	214:218	ASSSS	SPOP	0.9963	More...
O15534	Period circadian protein homolog 1	DEG_SPOP_SBC_1	652:656	ASSSS	SPOP	0.9988	More...
O43189	PHD finger protein 1	DEG_SPOP_SBC_1	495:499	ASSSS	SPOP	0.9504	More...
O43474	Krueppel-like factor 4	DEG_SPOP_SBC_1	130:134	ASSSS	SPOP	0.7205	More...
O75197	Low-density lipoprotein receptor-related protein 5	DEG_SPOP_SBC_1	1481:1485	ASSSS	SPOP	0.9948	More...
O75581	Low-density lipoprotein receptor-related protein 6	DEG_SPOP_SBC_1	1468:1472	ASSSS	SPOP	0.9959	More...
P08047	Transcription factor Sp1	DEG_SPOP_SBC_1	315:319	ASSSS	SPOP	0.8981	More...
P08069	Insulin-like growth factor 1 receptor	DEG_SPOP_SBC_1	1309:1313	ASSSS	SPOP	0.9782	More...
P11308	Transcriptional regulator ERG	DEG_SPOP_SBC_1	35:39	ASSSS	SPOP	0.992	More...
P25440	Bromodomain-containing protein 2	DEG_SPOP_SBC_1	776:780	ASSSS	SPOP	0.9929	More...
P31249	Homeobox protein Hox-D3	DEG_SPOP_SBC_1	149:153	ASSSS	SPOP	0.9801	More...
P32242	Homeobox protein OTX1	DEG_SPOP_SBC_1	136:140	ASSSS	SPOP	0.9354	More...
P32242	Homeobox protein OTX1	DEG_SPOP_SBC_1	142:146	ASSSS	SPOP	0.9168	More...
P34925	Tyrosine-protein kinase RYK	DEG_SPOP_SBC_1	266:270	ASSSS	SPOP	0.902	More...
P43356	Melanoma-associated antigen 2	DEG_SPOP_SBC_1	39:43	ASSSS	SPOP	0.94	More...
P43365	Melanoma-associated antigen 12	DEG_SPOP_SBC_1	39:43	ASSSS	SPOP	0.7923	More...
P48995	Short transient receptor potential channel 1	DEG_SPOP_SBC_1	14:18	ASSSS	SPOP	0.9293	More...
P49790	Nuclear pore complex protein Nup153	DEG_SPOP_SBC_1	772:776	ASSSS	SPOP	0.808	More...
P50548	ETS domain-containing transcription factor ERF	DEG_SPOP_SBC_1	364:368	ASSSS	SPOP	0.9956	More...
P51617	Interleukin-1 receptor-associated kinase 1	DEG_SPOP_SBC_1	651:655	ASSSS	SPOP	0.9942	More...
P54132	Bloom syndrome protein	DEG_SPOP_SBC_1	311:315	ASSSS	SPOP	0.9518	More...
P55198	Protein AF-17	DEG_SPOP_SBC_1	278:282	ASSSS	SPOP	0.9963	More...
P55198	Protein AF-17	DEG_SPOP_SBC_1	327:331	ASSSS	SPOP	0.9982	More...
P78424	POU domain, class 6, transcription factor 2	DEG_SPOP_SBC_1	447:451	ASSSS	SPOP	0.9845	More...
P80192	Mitogen-activated protein kinase kinase kinase 9	DEG_SPOP_SBC_1	1037:1041	ASSSS	SPOP	0.9687	More...
Q02388	Collagen alpha-1	DEG_SPOP_SBC_1	697:701	ASSSS	SPOP	0.9041	More...
Q03164	Histone-lysine N-methyltransferase 2A	DEG_SPOP_SBC_1	89:93	ASSSS	SPOP	0.9982	More...
Q03164	Histone-lysine N-methyltransferase 2A	DEG_SPOP_SBC_1	3335:3339	ASSSS	SPOP	0.7076	More...
Q04727	Transducin-like enhancer protein 4	DEG_SPOP_SBC_1	297:301	ASSSS	SPOP	0.9988	More...
Q08945	FACT complex subunit SSRP1	DEG_SPOP_SBC_1	501:505	ASSSS	SPOP	0.9979	More...
Q08AD1	Calmodulin-regulated spectrin-associated protein 2	DEG_SPOP_SBC_1	689:693	ASSSS	SPOP	0.9974	More...
Q12791	Calcium-activated potassium channel subunit alpha-1	DEG_SPOP_SBC_1	38:42	ASSSS	SPOP	0.9676	More...
Q12888	TP53-binding protein 1	DEG_SPOP_SBC_1	1641:1645	ASSSS	SPOP	0.9831	More...
Q12923	Tyrosine-protein phosphatase non-receptor type 13	DEG_SPOP_SBC_1	1745:1749	ASSSS	SPOP	0.9253	More...
Q12947	Forkhead box protein F2	DEG_SPOP_SBC_1	57:61	ASSSS	SPOP	0.9363	More...
Q13796	Protein Shroom2	DEG_SPOP_SBC_1	149:153	ASSSS	SPOP	0.9377	More...
Q14005	Pro-interleukin-16 [Cleaved into: Interleukin-16	DEG_SPOP_SBC_1	832:836	ASSSS	SPOP	0.9965	More...
Q15648	Mediator of RNA polymerase II transcription subunit 1	DEG_SPOP_SBC_1	1268:1272	ASSSS	SPOP	0.9827	More...
Q16891	MICOS complex subunit MIC60	DEG_SPOP_SBC_1	189:193	ASSSS	SPOP	0.8148	More...
Q2Q1W2	E3 ubiquitin-protein ligase TRIM71	DEG_SPOP_SBC_1	31:35	ASSSS	SPOP	0.8838	More...
Q3L8U1	Chromodomain-helicase-DNA-binding protein 9	DEG_SPOP_SBC_1	2174:2178	ASSSS	SPOP	0.9639	More...
Q569K4	Zinc finger protein 385B	DEG_SPOP_SBC_1	231:235	ASSSS	SPOP	0.8099	More...
Q5JU85	IQ motif and SEC7 domain-containing protein 2	DEG_SPOP_SBC_1	1230:1234	ASSSS	SPOP	0.8255	More...
Q5T4S7	E3 ubiquitin-protein ligase UBR4	DEG_SPOP_SBC_1	3345:3349	ASSSS	SPOP	0.9691	More...
Q5T6F2	Ubiquitin-associated protein 2	DEG_SPOP_SBC_1	777:781	ASSSS	SPOP	0.9765	More...
Q5TCX8	Mitogen-activated protein kinase kinase kinase 21	DEG_SPOP_SBC_1	25:29	ASSSS	SPOP	0.97	More...
Q5TCY1	Tau-tubulin kinase 1	DEG_SPOP_SBC_1	1109:1113	ASSSS	SPOP	0.9757	More...
Q5VT06	Centrosome-associated protein 350	DEG_SPOP_SBC_1	708:712	ASSSS	SPOP	0.9973	More...
Q5VT52	Regulation of nuclear pre-mRNA domain-containing protein 2	DEG_SPOP_SBC_1	12:16	ASSSS	SPOP	0.9241	More...
Q5VTR2	E3 ubiquitin-protein ligase BRE1A	DEG_SPOP_SBC_1	163:167	ASSSS	SPOP	0.5674	More...
Q5VV67	Peroxisome proliferator-activated receptor gamma coactivator-related protein 1	DEG_SPOP_SBC_1	1440:1444	ASSSS	SPOP	0.8903	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	548:552	ASSSS	SPOP	0.9987	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	607:611	ASSSS	SPOP	0.9585	More...
Q685J3	Mucin-17	DEG_SPOP_SBC_1	1079:1083	ASSSS	SPOP	0.9475	More...
Q6DJT9	Zinc finger protein PLAG1	DEG_SPOP_SBC_1	376:380	ASSSS	SPOP	0.9452	More...
Q6ZN04	RNA-binding protein MEX3B	DEG_SPOP_SBC_1	404:408	ASSSS	SPOP	0.8445	More...
Q6ZUT1	Uncharacterized protein NKAPD1	DEG_SPOP_SBC_1	234:238	ASSSS	SPOP	0.7532	More...
Q7Z3H0	Photoreceptor ankyrin repeat protein	DEG_SPOP_SBC_1	407:411	ASSSS	SPOP	0.9925	More...
Q7Z4V5	Hepatoma-derived growth factor-related protein 2	DEG_SPOP_SBC_1	254:258	ASSSS	SPOP	0.9555	More...
Q7Z5J4	Retinoic acid-induced protein 1	DEG_SPOP_SBC_1	1631:1635	ASSSS	SPOP	0.9194	More...
Q8IVL1	Neuron navigator 2	DEG_SPOP_SBC_1	1411:1415	ASSSS	SPOP	0.9427	More...
Q8IVW6	AT-rich interactive domain-containing protein 3B	DEG_SPOP_SBC_1	532:536	ASSSS	SPOP	0.9828	More...
Q8IXF0	Neuronal PAS domain-containing protein 3	DEG_SPOP_SBC_1	233:237	ASSSS	SPOP	0.8805	More...
Q8IXK0	Polyhomeotic-like protein 2	DEG_SPOP_SBC_1	23:27	ASSSS	SPOP	0.9155	More...
Q8IXZ2	Zinc finger CCCH domain-containing protein 3	DEG_SPOP_SBC_1	386:390	ASSSS	SPOP	0.9761	More...
Q8IXZ2	Zinc finger CCCH domain-containing protein 3	DEG_SPOP_SBC_1	872:876	ASSSS	SPOP	0.9634	More...
Q8IY26	Polyisoprenoid diphosphate/phosphate phosphohydrolase PLPP6	DEG_SPOP_SBC_1	17:21	ASSSS	SPOP	0.9988	More...
Q8N6K0	Testis-expressed protein 29	DEG_SPOP_SBC_1	108:112	ASSSS	SPOP	0.9978	More...
Q8TCU4	Alstrom syndrome protein 1	DEG_SPOP_SBC_1	1891:1895	ASSSS	SPOP	0.9753	More...
Q8TCU4	Alstrom syndrome protein 1	DEG_SPOP_SBC_1	3245:3249	ASSSS	SPOP	0.9886	More...
Q8WWN9	Interactor protein for cytohesin exchange factors 1	DEG_SPOP_SBC_1	183:187	ASSSS	SPOP	0.996	More...
Q8WWX8	Sodium/myo-inositol cotransporter 2	DEG_SPOP_SBC_1	587:591	ASSSS	SPOP	0.9469	More...
Q8WXH0	Nesprin-2	DEG_SPOP_SBC_1	4155:4159	ASSSS	SPOP	0.9945	More...
Q92734	Protein TFG	DEG_SPOP_SBC_1	211:215	ASSSS	SPOP	0.9523	More...
Q92794	Histone acetyltransferase KAT6A	DEG_SPOP_SBC_1	375:379	ASSSS	SPOP	0.9985	More...
Q92800	Histone-lysine N-methyltransferase EZH1	DEG_SPOP_SBC_1	397:401	ASSSS	SPOP	0.9923	More...
Q92833	Protein Jumonji	DEG_SPOP_SBC_1	1235:1239	ASSSS	SPOP	0.9876	More...
Q92833	Protein Jumonji	DEG_SPOP_SBC_1	1242:1246	ASSSS	SPOP	0.8412	More...
Q969Z3	Mitochondrial amidoxime reducing component 2	DEG_SPOP_SBC_1	3:7	ASSSS	SPOP	0.7836	More...
Q96L96	Alpha-protein kinase 3	DEG_SPOP_SBC_1	767:771	ASSSS	SPOP	0.9904	More...
Q96QT6	PHD finger protein 12	DEG_SPOP_SBC_1	928:932	ASSSS	SPOP	0.8699	More...
Q9BZS1	Forkhead box protein P3	DEG_SPOP_SBC_1	56:60	ASSSS	SPOP	0.8871	More...
Q9C0D6	FH2 domain-containing protein 1	DEG_SPOP_SBC_1	719:723	ASSSS	SPOP	0.867	More...
Q9H7S9	Zinc finger protein 703	DEG_SPOP_SBC_1	211:215	ASSSS	SPOP	0.9972	More...
Q9HCG8	Pre-mRNA-splicing factor CWC22 homolog	DEG_SPOP_SBC_1	674:678	ASSSS	SPOP	0.9842	More...
Q9HDB5	Neurexin-3-beta	DEG_SPOP_SBC_1	480:484	ASSSS	SPOP	0.9795	More...
Q9NPF5	DNA methyltransferase 1-associated protein 1	DEG_SPOP_SBC_1	455:459	ASSSS	SPOP	0.7946	More...
Q9NPG3	Ubinuclein-1	DEG_SPOP_SBC_1	867:871	ASSSS	SPOP	0.9938	More...
Q9NSI6	Bromodomain and WD repeat-containing protein 1	DEG_SPOP_SBC_1	1544:1548	ASSSS	SPOP	0.9686	More...
Q9NTI5	Sister chromatid cohesion protein PDS5 homolog B	DEG_SPOP_SBC_1	1158:1162	ASSSS	SPOP	0.9447	More...
Q9NY27	Serine/threonine-protein phosphatase 4 regulatory subunit 2	DEG_SPOP_SBC_1	278:282	ASSSS	SPOP	0.9992	More...
Q9P1Z0	Zinc finger and BTB domain-containing protein 4	DEG_SPOP_SBC_1	101:105	ASSSS	SPOP	0.9956	More...
Q9P286	Serine/threonine-protein kinase PAK 5	DEG_SPOP_SBC_1	222:226	ASSSS	SPOP	0.7523	More...
Q9UBN1	Voltage-dependent calcium channel gamma-4 subunit	DEG_SPOP_SBC_1	224:228	ASSSS	SPOP	0.7395	More...
Q9UFE4	Coiled-coil domain-containing protein 39	DEG_SPOP_SBC_1	927:931	ASSSS	SPOP	0.9527	More...
Q9UGU0	Transcription factor 20	DEG_SPOP_SBC_1	239:243	ASSSS	SPOP	0.9888	More...
Q9UJ98	Cohesin subunit SA-3	DEG_SPOP_SBC_1	18:22	ASSSS	SPOP	0.9571	More...
Q9UKB5	Adherens junction-associated protein 1	DEG_SPOP_SBC_1	131:135	ASSSS	SPOP	0.9942	More...
Q9ULI2	Beta-citrylglutamate synthase B	DEG_SPOP_SBC_1	346:350	ASSSS	SPOP	0.9949	More...
Q9UPA5	Protein bassoon	DEG_SPOP_SBC_1	2649:2653	ASSSS	SPOP	0.9177	More...
Q9UPS6	Histone-lysine N-methyltransferase SETD1B	DEG_SPOP_SBC_1	1049:1053	ASSSS	SPOP	0.9758	More...
Q9Y446	Plakophilin-3	DEG_SPOP_SBC_1	219:223	ASSSS	SPOP	0.9994	More...
Q9Y467	Sal-like protein 2	DEG_SPOP_SBC_1	255:259	ASSSS	SPOP	0.9956	More...
Q9Y4C0	Neurexin-3	DEG_SPOP_SBC_1	1486:1490	ASSSS	SPOP	0.9784	More...
Q9Y4X4	Krueppel-like factor 12	DEG_SPOP_SBC_1	136:140	ASSSS	SPOP	0.9685	More...
Q9Y566	SH3 and multiple ankyrin repeat domains protein 1	DEG_SPOP_SBC_1	1973:1977	ASSSS	SPOP	0.9913	More...
Q9Y5X1	Sorting nexin-9	DEG_SPOP_SBC_1	196:200	ASSSS	SPOP	0.9833	More...
A1L020	RNA-binding protein MEX3A	DEG_SPOP_SBC_1	408:412	ASSSS	SPOP	0.9395	More...
Q2KJY2	Kinesin-like protein KIF26B	DEG_SPOP_SBC_1	1648:1652	ASSSS	SPOP	0.861	More...
Q6T4P5	Phospholipid phosphatase-related protein type 3	DEG_SPOP_SBC_1	557:561	ASSSS	SPOP	0.9987	More...
Q86UZ6	Zinc finger and BTB domain-containing protein 46	DEG_SPOP_SBC_1	148:152	ASSSS	SPOP	0.8507	More...
Q8N143	B-cell CLL/lymphoma 6 member B protein	DEG_SPOP_SBC_1	233:237	ASSSS	SPOP	0.8845	More...
Q9ULI4	Kinesin-like protein KIF26A	DEG_SPOP_SBC_1	733:737	ASSSS	SPOP	0.9903	More...
Q6NT52	Choriogonadotropin subunit beta variant 2	DEG_SPOP_SBC_1	135:139	ASSSS	SPOP	0.9986	More...
Q9P227	Rho GTPase-activating protein 23	DEG_SPOP_SBC_1	1347:1351	ASSSS	SPOP	0.9739	More...
A6NNC1	Putative POM121-like protein 1-like	DEG_SPOP_SBC_1	392:396	ASSSS	SPOP	0.9991	More...
A6NNC1	Putative POM121-like protein 1-like	DEG_SPOP_SBC_1	666:670	ASSSS	SPOP	0.9988	More...
O15480	Melanoma-associated antigen B3	DEG_SPOP_SBC_1	340:344	ASSSS	SPOP	0.9907	More...
Q69YW2	Protein stum homolog	DEG_SPOP_SBC_1	25:29	ASSSS	SPOP	0.8246	More...
Q6PEV8	Protein FAM199X	DEG_SPOP_SBC_1	282:286	ASSSS	SPOP	0.9905	More...
Q86VQ1	Glucocorticoid-induced transcript 1 protein	DEG_SPOP_SBC_1	4:8	ASSSS	SPOP	0.8704	More...
Q9NQR7	Coiled-coil domain-containing protein 177	DEG_SPOP_SBC_1	250:254	ASSSS	SPOP	0.9585	More...
Q9NUC0	SERTA domain-containing protein 4	DEG_SPOP_SBC_1	222:226	ASSSS	SPOP	0.8625	More...
Q9NX31	Oxidative stress-responsive serine-rich protein 1	DEG_SPOP_SBC_1	99:103	ASSSS	SPOP	0.9942	More...
A8MZG2	Uncharacterized protein C16orf90	DEG_SPOP_SBC_1	134:138	ASSSS	SPOP	0.7432	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ASSSS

Degron related mutations and impact score

Drug responses associated with BRD2 mutations

All proteins holding degron of ASSSS