DegronMD - Q9NY27(PPP4R2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D286Y	TCGA-A5-A0G2	UCEC	TCGA	ASSSS	DEG_SPOP_SBC_1	278:282	Mutation rewiring degron network	0.2222
p.S371R	TCGA-AP-A1DK	UCEC	TCGA	PVSSS	DEG_SPOP_SBC_1	369:373	Mutation altering degron motif	0.7427
p.V273I	TCGA-AX-A1CE	UCEC	TCGA	ASSSS	DEG_SPOP_SBC_1	278:282	Mutation rewiring degron network	0.1944
p.R290C	TCGA-EO-A22S	UCEC	TCGA	ASSSS	DEG_SPOP_SBC_1	278:282	Mutation rewiring degron network	0.1111
p.D346N	DO2401	BRCA	ICGC	KDLLHSE	LIG_APCC_ABBAyCdc20_2	356:362	Mutation rewiring degron network	0.0556
p.L276S	DO229030	LICA	ICGC	ASSSS	DEG_SPOP_SBC_1	278:282	Mutation rewiring degron network	0.2778
p.L276S	DO229053	LICA	ICGC	ASSSS	DEG_SPOP_SBC_1	278:282	Mutation rewiring degron network	0.2778
p.L276S	DO229058	LICA	ICGC	ASSSS	DEG_SPOP_SBC_1	278:282	Mutation rewiring degron network	0.2778
p.L276S	DO229057	LICA	ICGC	ASSSS	DEG_SPOP_SBC_1	278:282	Mutation rewiring degron network	0.2778
p.Q288E	DO229052	LICA	ICGC	ASSSS	DEG_SPOP_SBC_1	278:282	Mutation rewiring degron network	0.1667
p.E348K	DO41542	UCEC	ICGC	KDLLHSE	LIG_APCC_ABBAyCdc20_2	356:362	Mutation rewiring degron network	0.1111
p.E362D	SIDM00961	Ewing's Sarcoma	GDSC	KDLLHSE	LIG_APCC_ABBAyCdc20_2	356:362	Mutation altering degron motif	0.5647
p.E362D	SIDM00530	Esophageal Carcinoma	GDSC	KDLLHSE	LIG_APCC_ABBAyCdc20_2	356:362	Mutation altering degron motif	0.5647
p.E362D	SIDM00568	Gastric Carcinoma	GDSC	KDLLHSE	LIG_APCC_ABBAyCdc20_2	356:362	Mutation altering degron motif	0.5647
p.E362D	SIDM00821	Kidney Carcinoma	GDSC	KDLLHSE	LIG_APCC_ABBAyCdc20_2	356:362	Mutation altering degron motif	0.5647
p.E362D	SIDM00817	Kidney Carcinoma	GDSC	KDLLHSE	LIG_APCC_ABBAyCdc20_2	356:362	Mutation altering degron motif	0.5647
p.E362D	SIDM00271	Gastric Carcinoma	GDSC	KDLLHSE	LIG_APCC_ABBAyCdc20_2	356:362	Mutation altering degron motif	0.5647
p.E362D	SIDM01454	Kidney Carcinoma	GDSC	KDLLHSE	LIG_APCC_ABBAyCdc20_2	356:362	Mutation altering degron motif	0.5647
p.E362D	OCUM-1	stomach	COSMIC	KDLLHSE	LIG_APCC_ABBAyCdc20_2	356:362	Mutation altering degron motif	0.5647
p.E362D	KYAE-1	oesophagus	COSMIC	KDLLHSE	LIG_APCC_ABBAyCdc20_2	356:362	Mutation altering degron motif	0.5647
p.E362D	CADO-ES1	bone	COSMIC	KDLLHSE	LIG_APCC_ABBAyCdc20_2	356:362	Mutation altering degron motif	0.5647
p.E362D	MKN1	stomach	COSMIC	KDLLHSE	LIG_APCC_ABBAyCdc20_2	356:362	Mutation altering degron motif	0.5647
p.S282C	SIDM01109	Other Sarcomas	GDSC	ASSSS	DEG_SPOP_SBC_1	278:282	Mutation altering degron motif	0.7541
p.S282C	SIDM00057	Neuroblastoma	GDSC	ASSSS	DEG_SPOP_SBC_1	278:282	Mutation altering degron motif	0.7541
p.S282C	SIDM00874	Breast Carcinoma	GDSC	ASSSS	DEG_SPOP_SBC_1	278:282	Mutation altering degron motif	0.7541
p.S282C	SIDM01124	Non-Small Cell Lung Carcinoma	GDSC	ASSSS	DEG_SPOP_SBC_1	278:282	Mutation altering degron motif	0.7541
p.S282C	SIDM01082	Oral Cavity Carcinoma	GDSC	ASSSS	DEG_SPOP_SBC_1	278:282	Mutation altering degron motif	0.7541
p.S282C	SIDM00903	Non-Small Cell Lung Carcinoma	GDSC	ASSSS	DEG_SPOP_SBC_1	278:282	Mutation altering degron motif	0.7541
p.S282C	SIDM00539	Esophageal Carcinoma	GDSC	ASSSS	DEG_SPOP_SBC_1	278:282	Mutation altering degron motif	0.7541
p.S282C	SIDM00101	Mesothelioma	GDSC	ASSSS	DEG_SPOP_SBC_1	278:282	Mutation altering degron motif	0.7541
p.S282C	SIDM00063	Melanoma	GDSC	ASSSS	DEG_SPOP_SBC_1	278:282	Mutation altering degron motif	0.7541
p.S282C	SIDM00873	Non-Cancerous	GDSC	ASSSS	DEG_SPOP_SBC_1	278:282	Mutation altering degron motif	0.7541
p.S282C	SIDM00736	Non-Cancerous	GDSC	ASSSS	DEG_SPOP_SBC_1	278:282	Mutation altering degron motif	0.7541
p.S282C	SIDM01778	B-Cell Non-Hodgkin's Lymphoma	GDSC	ASSSS	DEG_SPOP_SBC_1	278:282	Mutation altering degron motif	0.7541
p.Q353E	SIDM01069	Non-Small Cell Lung Carcinoma	GDSC	KDLLHSE	LIG_APCC_ABBAyCdc20_2	356:362	Mutation rewiring degron network	0.25
p.Q353E	ACH-000667	Lung Cancer	CCLE	KDLLHSE	LIG_APCC_ABBAyCdc20_2	356:362	Mutation rewiring degron network	0.25
p.Q353E	HCC-44	lung	COSMIC	KDLLHSE	LIG_APCC_ABBAyCdc20_2	356:362	Mutation rewiring degron network	0.25
p.N366K	SIDM01102	Non-Cancerous	GDSC	PVSSS	DEG_SPOP_SBC_1	369:373	Mutation rewiring degron network	0.25
p.N366K	SIDM01102	Non-Cancerous	GDSC	KDLLHSE	LIG_APCC_ABBAyCdc20_2	356:362	Mutation rewiring degron network	0.2222
p.N366K	ACH-002316	Non-Cancerous	CCLE	PVSSS	DEG_SPOP_SBC_1	369:373	Mutation rewiring degron network	0.25
p.N366K	ACH-002316	Non-Cancerous	CCLE	KDLLHSE	LIG_APCC_ABBAyCdc20_2	356:362	Mutation rewiring degron network	0.2222
p.N366K	WIL2-NS	haematopoietic and lymphoid tissue	COSMIC	PVSSS	DEG_SPOP_SBC_1	369:373	Mutation rewiring degron network	0.25
p.N366K	WIL2-NS	haematopoietic and lymphoid tissue	COSMIC	KDLLHSE	LIG_APCC_ABBAyCdc20_2	356:362	Mutation rewiring degron network	0.2222
p.S374Y	SIDM00793	Burkitt's Lymphoma	GDSC	PVSSS	DEG_SPOP_SBC_1	369:373	Mutation rewiring degron network	0.3056
p.S374Y	SIDM00431	T-Lymphoblastic Leukemia	GDSC	PVSSS	DEG_SPOP_SBC_1	369:373	Mutation rewiring degron network	0.3056
p.S374Y	SIDM01605	Non-Small Cell Lung Carcinoma	GDSC	PVSSS	DEG_SPOP_SBC_1	369:373	Mutation rewiring degron network	0.3056
p.D350V	SIDM01617	Endometrial Carcinoma	GDSC	KDLLHSE	LIG_APCC_ABBAyCdc20_2	356:362	Mutation rewiring degron network	0.1667
p.D350V	ACH-000994	Endometrial/Uterine Cancer	CCLE	KDLLHSE	LIG_APCC_ABBAyCdc20_2	356:362	Mutation rewiring degron network	0.1667

Kaplan plot for PPP4R2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PPP4R2

UniProt ID: Q9NY27

Entrez ID: 151987

Protein name: Serine/threonine-protein phosphatase 4 regulatory subunit 2

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PPP4R2 in