DegronMD

Uniprot ID: Q9NY27

Source protein: Serine/threonine-protein phosphatase 4 regulatory subunit 2

Source gene: PPP4R2

Class: LIG_APCC_ABBAyCdc20_2

Location: 356:362

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9867

ASA_SCORE: 117.8571

COIL: 0.7211

CONS_SCORE: 0.348

DSS_SCORE: 0.7782

HELIX: 0.2574

FCONS_SCORE: 1.0163

RIG_SCORE: 0.6426

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D346N	DO2401	BRCA	ICGC	KDLLHSE	LIG_APCC_ABBAyCdc20_2	0.0556
p.E348K	DO41542	UCEC	ICGC	KDLLHSE	LIG_APCC_ABBAyCdc20_2	0.1111
p.E362D	SIDM00961	Ewing's Sarcoma	GDSC	KDLLHSE	LIG_APCC_ABBAyCdc20_2	0.5647
p.E362D	SIDM00530	Esophageal Carcinoma	GDSC	KDLLHSE	LIG_APCC_ABBAyCdc20_2	0.5647
p.E362D	SIDM00568	Gastric Carcinoma	GDSC	KDLLHSE	LIG_APCC_ABBAyCdc20_2	0.5647
p.E362D	SIDM00821	Kidney Carcinoma	GDSC	KDLLHSE	LIG_APCC_ABBAyCdc20_2	0.5647
p.E362D	SIDM00817	Kidney Carcinoma	GDSC	KDLLHSE	LIG_APCC_ABBAyCdc20_2	0.5647
p.E362D	SIDM00271	Gastric Carcinoma	GDSC	KDLLHSE	LIG_APCC_ABBAyCdc20_2	0.5647
p.E362D	SIDM01454	Kidney Carcinoma	GDSC	KDLLHSE	LIG_APCC_ABBAyCdc20_2	0.5647
p.E362D	OCUM-1	stomach	COSMIC	KDLLHSE	LIG_APCC_ABBAyCdc20_2	0.5647
p.E362D	KYAE-1	oesophagus	COSMIC	KDLLHSE	LIG_APCC_ABBAyCdc20_2	0.5647
p.E362D	CADO-ES1	bone	COSMIC	KDLLHSE	LIG_APCC_ABBAyCdc20_2	0.5647
p.E362D	MKN1	stomach	COSMIC	KDLLHSE	LIG_APCC_ABBAyCdc20_2	0.5647
p.Q353E	SIDM01069	Non-Small Cell Lung Carcinoma	GDSC	KDLLHSE	LIG_APCC_ABBAyCdc20_2	0.25
p.Q353E	ACH-000667	Lung Cancer	CCLE	KDLLHSE	LIG_APCC_ABBAyCdc20_2	0.25
p.Q353E	HCC-44	lung	COSMIC	KDLLHSE	LIG_APCC_ABBAyCdc20_2	0.25
p.N366K	SIDM01102	Non-Cancerous	GDSC	KDLLHSE	LIG_APCC_ABBAyCdc20_2	0.2222
p.N366K	ACH-002316	Non-Cancerous	CCLE	KDLLHSE	LIG_APCC_ABBAyCdc20_2	0.2222
p.N366K	WIL2-NS	haematopoietic_and_lymphoid_tissue	COSMIC	KDLLHSE	LIG_APCC_ABBAyCdc20_2	0.2222
p.D350V	SIDM01617	Endometrial Carcinoma	GDSC	KDLLHSE	LIG_APCC_ABBAyCdc20_2	0.1667
p.D350V	ACH-000994	Endometrial/Uterine Cancer	CCLE	KDLLHSE	LIG_APCC_ABBAyCdc20_2	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9NY27	Serine/threonine-protein phosphatase 4 regulatory subunit 2	LIG_APCC_ABBAyCdc20_2	356:362	KDLLHSE	APC,CDC20,FZR1	0.9867	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: KDLLHSE

Degron related mutations and impact score

Drug responses associated with PPP4R2 mutations

All proteins holding degron of KDLLHSE