DegronMD - Q3L8U1(CHD9)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.H2327R	TCGA-75-7025	LUAD	TCGA	TEYSDPSVPTP	DEG_COP1_1	2308:2318	Mutation rewiring degron network	0.0833
p.H2327R	DO24840	LUAD	ICGC	TEYSDPSVPTP	DEG_COP1_1	2308:2318	Mutation rewiring degron network	0.0833
p.E407K	TCGA-A5-A0G2	UCEC	TCGA	LLPHFD	LIG_APCC_ABBA_1	414:419	Mutation rewiring degron network	0.1389
p.E407K	TCGA-AD-6889	COAD	TCGA	LLPHFD	LIG_APCC_ABBA_1	414:419	Mutation rewiring degron network	0.1389
p.E407K	TCGA-BR-6802	STAD	TCGA	LLPHFD	LIG_APCC_ABBA_1	414:419	Mutation rewiring degron network	0.1389
p.E407K	DO8463	COAD	ICGC	LLPHFD	LIG_APCC_ABBA_1	414:419	Mutation rewiring degron network	0.1389
p.E407K	DO38332	STAD	ICGC	LLPHFD	LIG_APCC_ABBA_1	414:419	Mutation rewiring degron network	0.1389
p.E407K	DO41235	UCEC	ICGC	LLPHFD	LIG_APCC_ABBA_1	414:419	Mutation rewiring degron network	0.1389
p.Q425H	TCGA-AJ-A3EL	UCEC	TCGA	LLPHFD	LIG_APCC_ABBA_1	414:419	Mutation rewiring degron network	0.1667
p.Q425H	DO41542	UCEC	ICGC	LLPHFD	LIG_APCC_ABBA_1	414:419	Mutation rewiring degron network	0.1667
p.P406L	TCGA-BG-A3EW	UCEC	TCGA	LLPHFD	LIG_APCC_ABBA_1	414:419	Mutation rewiring degron network	0.1111
p.P406L	DO48172	UCEC	ICGC	LLPHFD	LIG_APCC_ABBA_1	414:419	Mutation rewiring degron network	0.1111
p.L404R	TCGA-CD-A48A	STAD	TCGA	LLPHFD	LIG_APCC_ABBA_1	414:419	Mutation rewiring degron network	0.0556
p.L404R	DO47781	STAD	ICGC	LLPHFD	LIG_APCC_ABBA_1	414:419	Mutation rewiring degron network	0.0556
p.S2175Y	TCGA-FI-A2D5	UCEC	TCGA	ASSSS	DEG_SPOP_SBC_1	2174:2178	Mutation altering degron motif	0.6009
p.S2175Y	DO41331	UCEC	ICGC	ASSSS	DEG_SPOP_SBC_1	2174:2178	Mutation altering degron motif	0.6009
p.D2312N	TCGA-HF-7132	STAD	TCGA	TEYSDPSVPTP	DEG_COP1_1	2308:2318	Mutation altering degron motif	0.5821
p.G2322S	TCGA-L5-A43I	ESCA	TCGA	TEYSDPSVPTP	DEG_COP1_1	2308:2318	Mutation rewiring degron network	0.2222
p.D2312E	DO229010	COCA	ICGC	TEYSDPSVPTP	DEG_COP1_1	2308:2318	Mutation altering degron motif	0.5647
p.D2312E	DO229013	COCA	ICGC	TEYSDPSVPTP	DEG_COP1_1	2308:2318	Mutation altering degron motif	0.5647
p.D2312E	DO229016	COCA	ICGC	TEYSDPSVPTP	DEG_COP1_1	2308:2318	Mutation altering degron motif	0.5647
p.D2312E	DO229003	COCA	ICGC	TEYSDPSVPTP	DEG_COP1_1	2308:2318	Mutation altering degron motif	0.5647
p.D2312E	DO229005	COCA	ICGC	TEYSDPSVPTP	DEG_COP1_1	2308:2318	Mutation altering degron motif	0.5647
p.S2315R	DO229013	COCA	ICGC	TEYSDPSVPTP	DEG_COP1_1	2308:2318	Mutation altering degron motif	0.7427
p.S2164R	DO228882	MALY	ICGC	ASSSS	DEG_SPOP_SBC_1	2174:2178	Mutation rewiring degron network	0.0556
p.S2167L	DO220852	MELA	ICGC	ASSSS	DEG_SPOP_SBC_1	2174:2178	Mutation rewiring degron network	0.1389
p.D2313N	DO38214	STAD	ICGC	TEYSDPSVPTP	DEG_COP1_1	2308:2318	Mutation altering degron motif	0.6932
p.S2166P	SIDM00693	Bladder Carcinoma	GDSC	ASSSS	DEG_SPOP_SBC_1	2174:2178	Mutation rewiring degron network	0.1111
p.S2166P	SIDM01732	Non-Cancerous	GDSC	ASSSS	DEG_SPOP_SBC_1	2174:2178	Mutation rewiring degron network	0.1111
p.S2187F	SIDM00006	Other Solid Cancers	GDSC	ASSSS	DEG_SPOP_SBC_1	2174:2178	Mutation blocking phosphorylation signal	0.5278
p.S2187F	ACH-001552	Skin Cancer	CCLE	ASSSS	DEG_SPOP_SBC_1	2174:2178	Mutation blocking phosphorylation signal	0.5278
p.S2187F	MCC26	skin	COSMIC	ASSSS	DEG_SPOP_SBC_1	2174:2178	Mutation blocking phosphorylation signal	0.5278
p.A2174V	SIDM00999	Bladder Carcinoma	GDSC	ASSSS	DEG_SPOP_SBC_1	2174:2178	Mutation altering degron motif	0.5825
p.A2174V	ACH-000973	Bladder Cancer	CCLE	ASSSS	DEG_SPOP_SBC_1	2174:2178	Mutation altering degron motif	0.5825
p.A2174V	639-V	urinary tract	COSMIC	ASSSS	DEG_SPOP_SBC_1	2174:2178	Mutation altering degron motif	0.5825
p.G2322C	SIDM00658	Non-Small Cell Lung Carcinoma	GDSC	TEYSDPSVPTP	DEG_COP1_1	2308:2318	Mutation rewiring degron network	0.2222
p.G2322C	ACH-000852	Lung Cancer	CCLE	TEYSDPSVPTP	DEG_COP1_1	2308:2318	Mutation rewiring degron network	0.2222
p.G2322C	NCI-H1435	lung	COSMIC	TEYSDPSVPTP	DEG_COP1_1	2308:2318	Mutation rewiring degron network	0.2222
p.S2773Y	SIDM00118	Colorectal Carcinoma	GDSC	PSTSS	DEG_SPOP_SBC_1	2774:2778	Mutation rewiring degron network	0.3056
p.S2773Y	HCC2998	large intestine	COSMIC	PSTSS	DEG_SPOP_SBC_1	2774:2778	Mutation rewiring degron network	0.3056
p.C2171Y	ACH-001857	Bile Duct Cancer	CCLE	ASSSS	DEG_SPOP_SBC_1	2174:2178	Mutation rewiring degron network	0.25
p.R407G	OV-17R	ovary	COSMIC	LLPHFD	LIG_APCC_ABBA_1	414:419	Mutation rewiring degron network	0.1389
p.A2307T	LNCaP-Clone-FGC	prostate	COSMIC	TEYSDPSVPTP	DEG_COP1_1	2308:2318	Mutation rewiring degron network	0.3056
p.K409N	CW-2	large intestine	COSMIC	LLPHFD	LIG_APCC_ABBA_1	414:419	Mutation rewiring degron network	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CHD9

UniProt ID: Q3L8U1

Entrez ID: 80205

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CHD9 in