DegronMD

Uniprot ID: Q3L8U1

Source protein: Chromodomain-helicase-DNA-binding protein 9

Source gene: CHD9

Class: DEG_COP1_1

Location: 2308:2318

E3 ligase: COP1

DEGRON score: 0.9377

ASA_SCORE: 90.3818

COIL: 0.9537

CONS_SCORE: 0.3435

DSS_SCORE: 0.6647

HELIX: 0.0197

FCONS_SCORE: 1.0238

RIG_SCORE: 0.627

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H2327R	TCGA-75-7025	LUAD	TCGA	TEYSDPSVPTP	DEG_COP1_1	0.0833
p.H2327R	DO24840	LUAD	ICGC	TEYSDPSVPTP	DEG_COP1_1	0.0833
p.D2312N	TCGA-HF-7132	STAD	TCGA	TEYSDPSVPTP	DEG_COP1_1	0.5821
p.G2322S	TCGA-L5-A43I	ESCA	TCGA	TEYSDPSVPTP	DEG_COP1_1	0.2222
p.D2312E	DO229010	COCA	ICGC	TEYSDPSVPTP	DEG_COP1_1	0.5647
p.D2312E	DO229013	COCA	ICGC	TEYSDPSVPTP	DEG_COP1_1	0.5647
p.D2312E	DO229016	COCA	ICGC	TEYSDPSVPTP	DEG_COP1_1	0.5647
p.D2312E	DO229003	COCA	ICGC	TEYSDPSVPTP	DEG_COP1_1	0.5647
p.D2312E	DO229005	COCA	ICGC	TEYSDPSVPTP	DEG_COP1_1	0.5647
p.S2315R	DO229013	COCA	ICGC	TEYSDPSVPTP	DEG_COP1_1	0.7427
p.D2313N	DO38214	STAD	ICGC	TEYSDPSVPTP	DEG_COP1_1	0.6932
p.G2322C	SIDM00658	Non-Small Cell Lung Carcinoma	GDSC	TEYSDPSVPTP	DEG_COP1_1	0.2222
p.G2322C	ACH-000852	Lung Cancer	CCLE	TEYSDPSVPTP	DEG_COP1_1	0.2222
p.G2322C	NCI-H1435	lung	COSMIC	TEYSDPSVPTP	DEG_COP1_1	0.2222
p.A2307T	LNCaP-Clone-FGC	prostate	COSMIC	TEYSDPSVPTP	DEG_COP1_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q3L8U1	Chromodomain-helicase-DNA-binding protein 9	DEG_COP1_1	2308:2318	TEYSDPSVPTP	COP1	0.9377	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons