DegronMD

Uniprot ID: Q3L8U1

Source protein: Chromodomain-helicase-DNA-binding protein 9

Source gene: CHD9

Class: LIG_APCC_ABBA_1

Location: 414:419

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7292

ASA_SCORE: 86.7667

COIL: 0.8823

CONS_SCORE: 0.311

DSS_SCORE: 0.5514

HELIX: 0.0763

FCONS_SCORE: 0.9677

RIG_SCORE: 0.7436

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E407K	TCGA-A5-A0G2	UCEC	TCGA	LLPHFD	LIG_APCC_ABBA_1	0.1389
p.E407K	TCGA-AD-6889	COAD	TCGA	LLPHFD	LIG_APCC_ABBA_1	0.1389
p.E407K	TCGA-BR-6802	STAD	TCGA	LLPHFD	LIG_APCC_ABBA_1	0.1389
p.E407K	DO8463	COAD	ICGC	LLPHFD	LIG_APCC_ABBA_1	0.1389
p.E407K	DO38332	STAD	ICGC	LLPHFD	LIG_APCC_ABBA_1	0.1389
p.E407K	DO41235	UCEC	ICGC	LLPHFD	LIG_APCC_ABBA_1	0.1389
p.Q425H	TCGA-AJ-A3EL	UCEC	TCGA	LLPHFD	LIG_APCC_ABBA_1	0.1667
p.Q425H	DO41542	UCEC	ICGC	LLPHFD	LIG_APCC_ABBA_1	0.1667
p.P406L	TCGA-BG-A3EW	UCEC	TCGA	LLPHFD	LIG_APCC_ABBA_1	0.1111
p.P406L	DO48172	UCEC	ICGC	LLPHFD	LIG_APCC_ABBA_1	0.1111
p.L404R	TCGA-CD-A48A	STAD	TCGA	LLPHFD	LIG_APCC_ABBA_1	0.0556
p.L404R	DO47781	STAD	ICGC	LLPHFD	LIG_APCC_ABBA_1	0.0556
p.R407G	OV-17R	ovary	COSMIC	LLPHFD	LIG_APCC_ABBA_1	0.1389
p.K409N	CW-2	large_intestine	COSMIC	LLPHFD	LIG_APCC_ABBA_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q3L8U1	Chromodomain-helicase-DNA-binding protein 9	LIG_APCC_ABBA_1	414:419	LLPHFD	APC,CDC20,FZR1	0.7292	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons