DegronMD - Q9ULI2(RIMKLB)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.N372H	TCGA-60-2725	LUSC	TCGA	ERELLTKLP	DEG_APCC_DBOX_1	359:367	Mutation rewiring degron network	0.1944
p.N372H	DO26674	LUSC	ICGC	ERELLTKLP	DEG_APCC_DBOX_1	359:367	Mutation rewiring degron network	0.1944
p.L377R	TCGA-AR-A0TY	BRCA	TCGA	ERELLTKLP	DEG_APCC_DBOX_1	359:367	Mutation rewiring degron network	0.0556
p.L377R	DO1322	BRCA	ICGC	ERELLTKLP	DEG_APCC_DBOX_1	359:367	Mutation rewiring degron network	0.0556
p.N374S	TCGA-CG-4442	STAD	TCGA	ERELLTKLP	DEG_APCC_DBOX_1	359:367	Mutation rewiring degron network	0.1389
p.N374S	DO38380	STAD	ICGC	ERELLTKLP	DEG_APCC_DBOX_1	359:367	Mutation rewiring degron network	0.1389
p.F371L	TCGA-CQ-5331	HNSC	TCGA	ERELLTKLP	DEG_APCC_DBOX_1	359:367	Mutation rewiring degron network	0.2222
p.F371L	DO15495	HNSC	ICGC	ERELLTKLP	DEG_APCC_DBOX_1	359:367	Mutation rewiring degron network	0.2222
p.D342H	TCGA-E7-A4IJ	BLCA	TCGA	ASSSS	DEG_SPOP_SBC_1	346:350	Mutation rewiring degron network	0.2222
p.D342H	DO453	BLCA	ICGC	ASSSS	DEG_SPOP_SBC_1	346:350	Mutation rewiring degron network	0.2222
p.P355S	TCGA-EE-A2M5	SKCM	TCGA	ERELLTKLP	DEG_APCC_DBOX_1	359:367	Mutation rewiring degron network	0.2222
p.P355S	TCGA-EE-A2M5	SKCM	TCGA	ASSSS	DEG_SPOP_SBC_1	346:350	Mutation rewiring degron network	0.1944
p.P355S	DO37425	SKCM	ICGC	ERELLTKLP	DEG_APCC_DBOX_1	359:367	Mutation rewiring degron network	0.2222
p.P355S	DO37425	SKCM	ICGC	ASSSS	DEG_SPOP_SBC_1	346:350	Mutation rewiring degron network	0.1944
p.T358M	TCGA-FI-A2D0	UCEC	TCGA	ERELLTKLP	DEG_APCC_DBOX_1	359:367	Mutation blocking phosphorylation signal	0.75
p.T358M	TCGA-FI-A2D0	UCEC	TCGA	ASSSS	DEG_SPOP_SBC_1	346:350	Mutation blocking phosphorylation signal	0.5556
p.T358M	DO43891	UCEC	ICGC	ERELLTKLP	DEG_APCC_DBOX_1	359:367	Mutation blocking phosphorylation signal	0.75
p.T358M	DO43891	UCEC	ICGC	ASSSS	DEG_SPOP_SBC_1	346:350	Mutation blocking phosphorylation signal	0.5556
p.T358M	SIDM00844	Burkitt's Lymphoma	GDSC	ERELLTKLP	DEG_APCC_DBOX_1	359:367	Mutation blocking phosphorylation signal	0.75
p.T358M	SIDM00844	Burkitt's Lymphoma	GDSC	ASSSS	DEG_SPOP_SBC_1	346:350	Mutation blocking phosphorylation signal	0.5556
p.T358M	SIDM01042	Breast Carcinoma	GDSC	ERELLTKLP	DEG_APCC_DBOX_1	359:367	Mutation blocking phosphorylation signal	0.75
p.T358M	SIDM01042	Breast Carcinoma	GDSC	ASSSS	DEG_SPOP_SBC_1	346:350	Mutation blocking phosphorylation signal	0.5556
p.S347R	TCGA-IB-7651	PAAD	TCGA	ASSSS	DEG_SPOP_SBC_1	346:350	Mutation altering degron motif	0.7427
p.S347R	DO46657	PAAD	ICGC	ASSSS	DEG_SPOP_SBC_1	346:350	Mutation altering degron motif	0.7427
p.V341I	DO233732	GACA	ICGC	ASSSS	DEG_SPOP_SBC_1	346:350	Mutation rewiring degron network	0.1944
p.G369C	DO229034	LICA	ICGC	ERELLTKLP	DEG_APCC_DBOX_1	359:367	Mutation rewiring degron network	0.2778
p.DP354DS	DO222423	MELA	ICGC	ERELLTKLP	DEG_APCC_DBOX_1	359:367	Mutation rewiring degron network	0
p.DP354DS	DO222423	MELA	ICGC	ASSSS	DEG_SPOP_SBC_1	346:350	Mutation rewiring degron network	0
p.S345R	DO51474	PACA	ICGC	ASSSS	DEG_SPOP_SBC_1	346:350	Mutation rewiring degron network	0.3056
p.S357N	DO229248	THCA	ICGC	ERELLTKLP	DEG_APCC_DBOX_1	359:367	Mutation rewiring degron network	0.2778
p.S357N	DO229248	THCA	ICGC	ASSSS	DEG_SPOP_SBC_1	346:350	Mutation rewiring degron network	0.1389
p.L362M	SIDM00845	Burkitt's Lymphoma	GDSC	ERELLTKLP	DEG_APCC_DBOX_1	359:367	Mutation altering degron motif	0.5999
p.L370V	SIDM00138	Non-Small Cell Lung Carcinoma	GDSC	ERELLTKLP	DEG_APCC_DBOX_1	359:367	Mutation rewiring degron network	0.25
p.L370V	NCI-H23	lung	COSMIC	ERELLTKLP	DEG_APCC_DBOX_1	359:367	Mutation rewiring degron network	0.25
p.A337D	SIDM00166	Other Solid Cancers	GDSC	ASSSS	DEG_SPOP_SBC_1	346:350	Mutation rewiring degron network	0.0833
p.A337D	ACH-000302	Endometrial/Uterine Cancer	CCLE	ASSSS	DEG_SPOP_SBC_1	346:350	Mutation rewiring degron network	0.0833
p.D354Y	ACH-000428	Kidney Cancer	CCLE	ERELLTKLP	DEG_APCC_DBOX_1	359:367	Mutation rewiring degron network	0.1944
p.D354Y	ACH-000428	Kidney Cancer	CCLE	ASSSS	DEG_SPOP_SBC_1	346:350	Mutation rewiring degron network	0.2222
p.E356K	ACH-001022	Bone Cancer	CCLE	ERELLTKLP	DEG_APCC_DBOX_1	359:367	Mutation rewiring degron network	0.25
p.E356K	ACH-001022	Bone Cancer	CCLE	ASSSS	DEG_SPOP_SBC_1	346:350	Mutation rewiring degron network	0.1667

Kaplan plot for RIMKLB in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

RIMKLB

UniProt ID: Q9ULI2

Entrez ID: 57494

Protein name: Beta-citrylglutamate synthase B (EC 6.3.1.17) (N-acetyl-aspartylglutamate synthetase B) (NAAG synthetase B) (NAAGS) (EC 6.3.2.41) (Ribosomal protein S6 modification-like protein B)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for RIMKLB in