DegronMD

Uniprot ID: Q9ULI2

Source protein: Beta-citrylglutamate synthase B

Source gene: RIMKLB

Class: DEG_APCC_DBOX_1

Location: 359:367

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7592

ASA_SCORE: 84.8667

COIL: 0.6461

CONS_SCORE: 0.2815

DSS_SCORE: 0.494

HELIX: 0.255

FCONS_SCORE: 0.9335

RIG_SCORE: 0.7747

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N372H	TCGA-60-2725	LUSC	TCGA	ERELLTKLP	DEG_APCC_DBOX_1	0.1944
p.N372H	DO26674	LUSC	ICGC	ERELLTKLP	DEG_APCC_DBOX_1	0.1944
p.L377R	TCGA-AR-A0TY	BRCA	TCGA	ERELLTKLP	DEG_APCC_DBOX_1	0.0556
p.L377R	DO1322	BRCA	ICGC	ERELLTKLP	DEG_APCC_DBOX_1	0.0556
p.N374S	TCGA-CG-4442	STAD	TCGA	ERELLTKLP	DEG_APCC_DBOX_1	0.1389
p.N374S	DO38380	STAD	ICGC	ERELLTKLP	DEG_APCC_DBOX_1	0.1389
p.F371L	TCGA-CQ-5331	HNSC	TCGA	ERELLTKLP	DEG_APCC_DBOX_1	0.2222
p.F371L	DO15495	HNSC	ICGC	ERELLTKLP	DEG_APCC_DBOX_1	0.2222
p.P355S	TCGA-EE-A2M5	SKCM	TCGA	ERELLTKLP	DEG_APCC_DBOX_1	0.2222
p.P355S	DO37425	SKCM	ICGC	ERELLTKLP	DEG_APCC_DBOX_1	0.2222
p.T358M	TCGA-FI-A2D0	UCEC	TCGA	ERELLTKLP	DEG_APCC_DBOX_1	0.75
p.T358M	DO43891	UCEC	ICGC	ERELLTKLP	DEG_APCC_DBOX_1	0.75
p.T358M	SIDM00844	Burkitt's Lymphoma	GDSC	ERELLTKLP	DEG_APCC_DBOX_1	0.75
p.T358M	SIDM01042	Breast Carcinoma	GDSC	ERELLTKLP	DEG_APCC_DBOX_1	0.75
p.G369C	DO229034	LICA	ICGC	ERELLTKLP	DEG_APCC_DBOX_1	0.2778
p.DP354DS	DO222423	MELA	ICGC	ERELLTKLP	DEG_APCC_DBOX_1	0
p.S357N	DO229248	THCA	ICGC	ERELLTKLP	DEG_APCC_DBOX_1	0.2778
p.L362M	SIDM00845	Burkitt's Lymphoma	GDSC	ERELLTKLP	DEG_APCC_DBOX_1	0.5999
p.L370V	SIDM00138	Non-Small Cell Lung Carcinoma	GDSC	ERELLTKLP	DEG_APCC_DBOX_1	0.25
p.L370V	NCI-H23	lung	COSMIC	ERELLTKLP	DEG_APCC_DBOX_1	0.25
p.D354Y	ACH-000428	Kidney Cancer	CCLE	ERELLTKLP	DEG_APCC_DBOX_1	0.1944
p.E356K	ACH-001022	Bone Cancer	CCLE	ERELLTKLP	DEG_APCC_DBOX_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9ULI2	Beta-citrylglutamate synthase B	DEG_APCC_DBOX_1	359:367	ERELLTKLP	APC,CDC20,FZR1	0.7592	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons