DegronMD - Q92734(TFG)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P220S	TCGA-2W-A8YY	CESC	TCGA	ASSSS	DEG_SPOP_SBC_1	211:215	Mutation rewiring degron network	0.1944
p.P220S	DO223732	CESC	ICGC	ASSSS	DEG_SPOP_SBC_1	211:215	Mutation rewiring degron network	0.1944
p.S209C	TCGA-91-6848	LUAD	TCGA	ASSSS	DEG_SPOP_SBC_1	211:215	Mutation blocking phosphorylation signal	0.7222
p.S209C	DO23846	LUAD	ICGC	ASSSS	DEG_SPOP_SBC_1	211:215	Mutation blocking phosphorylation signal	0.7222
p.A382V	TCGA-A5-A0G1	UCEC	TCGA	MTPPPS	DEG_SCF_FBW7_1	371:376	Mutation rewiring degron network	0.1667
p.A382V	DO225346	BRCA	ICGC	MTPPPS	DEG_SCF_FBW7_1	371:376	Mutation rewiring degron network	0.1667
p.A382V	DO42472	UCEC	ICGC	MTPPPS	DEG_SCF_FBW7_1	371:376	Mutation rewiring degron network	0.1667
p.A382V	SIDM00889	Cervical Carcinoma	GDSC	MTPPPS	DEG_SCF_FBW7_1	371:376	Mutation rewiring degron network	0.1667
p.A382V	C-33-A	cervix	COSMIC	MTPPPS	DEG_SCF_FBW7_1	371:376	Mutation rewiring degron network	0.1667
p.R383C	TCGA-AA-3715	COAD	TCGA	MTPPPS	DEG_SCF_FBW7_1	371:376	Mutation rewiring degron network	0.1389
p.R383C	DO8018	COAD	ICGC	MTPPPS	DEG_SCF_FBW7_1	371:376	Mutation rewiring degron network	0.1389
p.R385H	TCGA-AA-A010	COAD	TCGA	MTPPPS	DEG_SCF_FBW7_1	371:376	Mutation rewiring degron network	0.0833
p.R385H	SIDM00433	T-Lymphoblastic Leukemia	GDSC	MTPPPS	DEG_SCF_FBW7_1	371:376	Mutation rewiring degron network	0.0833
p.R385H	ACH-000795	Leukemia	CCLE	MTPPPS	DEG_SCF_FBW7_1	371:376	Mutation rewiring degron network	0.0833
p.R385H	MOLT-13	haematopoietic and lymphoid tissue	COSMIC	MTPPPS	DEG_SCF_FBW7_1	371:376	Mutation rewiring degron network	0.0833
p.S209I	TCGA-AX-A06F	UCEC	TCGA	ASSSS	DEG_SPOP_SBC_1	211:215	Mutation blocking phosphorylation signal	0.7222
p.S209I	DO41752	UCEC	ICGC	ASSSS	DEG_SPOP_SBC_1	211:215	Mutation blocking phosphorylation signal	0.7222
p.P361Q	TCGA-B5-A3FA	UCEC	TCGA	MTPPPS	DEG_SCF_FBW7_1	371:376	Mutation rewiring degron network	0.0556
p.P361Q	DO52402	UCEC	ICGC	MTPPPS	DEG_SCF_FBW7_1	371:376	Mutation rewiring degron network	0.0556
p.H218Y	TCGA-B5-A3S1	UCEC	TCGA	ASSSS	DEG_SPOP_SBC_1	211:215	Mutation rewiring degron network	0.25
p.H218Y	DO41277	UCEC	ICGC	ASSSS	DEG_SPOP_SBC_1	211:215	Mutation rewiring degron network	0.25
p.R203C	TCGA-DK-AA6U	BLCA	TCGA	ASSSS	DEG_SPOP_SBC_1	211:215	Mutation rewiring degron network	0.1111
p.R203C	TCGA-FR-A3R1	SKCM	TCGA	ASSSS	DEG_SPOP_SBC_1	211:215	Mutation rewiring degron network	0.1111
p.R203C	DO219008	BLCA	ICGC	ASSSS	DEG_SPOP_SBC_1	211:215	Mutation rewiring degron network	0.1111
p.R203C	DO37991	SKCM	ICGC	ASSSS	DEG_SPOP_SBC_1	211:215	Mutation rewiring degron network	0.1111
p.T372A	DO227906	COCA	ICGC	MTPPPS	DEG_SCF_FBW7_1	371:376	Mutation altering degron motif	0.825
p.Q225L	DO228278	LICA	ICGC	ASSSS	DEG_SPOP_SBC_1	211:215	Mutation rewiring degron network	0.0556
p.A382S	DO228948	LICA	ICGC	MTPPPS	DEG_SCF_FBW7_1	371:376	Mutation rewiring degron network	0.1667
p.R385L	DO229019	LICA	ICGC	MTPPPS	DEG_SCF_FBW7_1	371:376	Mutation rewiring degron network	0.0833
p.G362C	DO229035	LICA	ICGC	MTPPPS	DEG_SCF_FBW7_1	371:376	Mutation rewiring degron network	0.0833
p.P374S	DO231706	LINC	ICGC	MTPPPS	DEG_SCF_FBW7_1	371:376	Mutation altering degron motif	0.5641
p.R385C	DO45299	LIRI	ICGC	MTPPPS	DEG_SCF_FBW7_1	371:376	Mutation rewiring degron network	0.0833
p.R203G	DO45127	LIRI	ICGC	ASSSS	DEG_SPOP_SBC_1	211:215	Mutation rewiring degron network	0.1111
p.T364P	SIDM00967	Ovarian Carcinoma	GDSC	MTPPPS	DEG_SCF_FBW7_1	371:376	Mutation rewiring degron network	0.1389
p.T364P	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	MTPPPS	DEG_SCF_FBW7_1	371:376	Mutation rewiring degron network	0.1389
p.T364P	SIDM00309	Mesothelioma	GDSC	MTPPPS	DEG_SCF_FBW7_1	371:376	Mutation rewiring degron network	0.1389
p.T364P	SIDM00431	T-Lymphoblastic Leukemia	GDSC	MTPPPS	DEG_SCF_FBW7_1	371:376	Mutation rewiring degron network	0.1389
p.T364P	SIDM01409	Bladder Carcinoma	GDSC	MTPPPS	DEG_SCF_FBW7_1	371:376	Mutation rewiring degron network	0.1389
p.A217S	SIDM00763	Non-Small Cell Lung Carcinoma	GDSC	ASSSS	DEG_SPOP_SBC_1	211:215	Mutation rewiring degron network	0.2778
p.A217S	SIDM00939	Non-Small Cell Lung Carcinoma	GDSC	ASSSS	DEG_SPOP_SBC_1	211:215	Mutation rewiring degron network	0.2778
p.A217S	ACH-000434	Lung Cancer	CCLE	ASSSS	DEG_SPOP_SBC_1	211:215	Mutation rewiring degron network	0.2778
p.A217S	ACH-000826	Lung Cancer	CCLE	ASSSS	DEG_SPOP_SBC_1	211:215	Mutation rewiring degron network	0.2778
p.A217S	CAL-12T	lung	COSMIC	ASSSS	DEG_SPOP_SBC_1	211:215	Mutation rewiring degron network	0.2778
p.A217S	NCI-H1915	lung	COSMIC	ASSSS	DEG_SPOP_SBC_1	211:215	Mutation rewiring degron network	0.2778
p.R383H	SIDM00238	Ovarian Carcinoma	GDSC	MTPPPS	DEG_SCF_FBW7_1	371:376	Mutation rewiring degron network	0.1389
p.R383H	SIDM00365	Small Cell Lung Carcinoma	GDSC	MTPPPS	DEG_SCF_FBW7_1	371:376	Mutation rewiring degron network	0.1389
p.R383H	ACH-000947	Ovarian Cancer	CCLE	MTPPPS	DEG_SCF_FBW7_1	371:376	Mutation rewiring degron network	0.1389
p.R383H	ACH-002196	Lung Cancer	CCLE	MTPPPS	DEG_SCF_FBW7_1	371:376	Mutation rewiring degron network	0.1389
p.R383H	OVK-18	ovary	COSMIC	MTPPPS	DEG_SCF_FBW7_1	371:376	Mutation rewiring degron network	0.1389
p.P386L	SIDM00415	B-Cell Non-Hodgkin's Lymphoma	GDSC	MTPPPS	DEG_SCF_FBW7_1	371:376	Mutation rewiring degron network	0.0556
p.P386L	ACH-001639	Leukemia	CCLE	MTPPPS	DEG_SCF_FBW7_1	371:376	Mutation rewiring degron network	0.0556
p.P386L	ROS-50	haematopoietic and lymphoid tissue	COSMIC	MTPPPS	DEG_SCF_FBW7_1	371:376	Mutation rewiring degron network	0.0556
p.G377R	SIDM01664	Prostate Carcinoma	GDSC	MTPPPS	DEG_SCF_FBW7_1	371:376	Mutation rewiring degron network	0.3056
p.G377R	ACH-000952	Prostate Cancer	CCLE	MTPPPS	DEG_SCF_FBW7_1	371:376	Mutation rewiring degron network	0.3056
p.R379H	OVK-18	ovary	COSMIC	MTPPPS	DEG_SCF_FBW7_1	371:376	Mutation rewiring degron network	0.25
p.A378V	C-33-A	cervix	COSMIC	MTPPPS	DEG_SCF_FBW7_1	371:376	Mutation rewiring degron network	0.2778
p.R381H	MOLT-13	haematopoietic and lymphoid tissue	COSMIC	MTPPPS	DEG_SCF_FBW7_1	371:376	Mutation blocking phosphorylation signal	0.6389
p.P382L	ROS-50	haematopoietic and lymphoid tissue	COSMIC	MTPPPS	DEG_SCF_FBW7_1	371:376	Mutation rewiring degron network	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TFG

UniProt ID: Q92734

Entrez ID: 10342

Protein name: Protein TFG (TRK-fused gene protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TFG in