DegronMD - Q92734(TFG)

FUNCTION: Plays a role in the normal dynamic function of the endoplasmic reticulum (ER) and its associated microtubules (PubMed:23479643, PubMed:27813252). Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus (PubMed:21478858). {ECO:0000269|PubMed:21478858, ECO:0000269|PubMed:23479643, ECO:0000269|PubMed:27813252}.

GO - Biological processes (BP): COPII vesicle coating [GO:0048208]; endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888]; positive regulation of I-kappaB kinase/NF-kappaB signaling [GO:0043123]

GO - Molecular function (MF): identical protein binding [GO:0042802]

GO - Cellular component (CC): cytoplasm [GO:0005737]; cytosol [GO:0005829]; endoplasmic reticulum exit site [GO:0070971]; intracellular membrane-bounded organelle [GO:0043231]

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T372A	DO227906	COCA	ICGC	MTPPPS	DEG_SCF_FBW7_1	371:376	Mutation altering degron motif	0.825
p.S209C	TCGA-91-6848	LUAD	TCGA	ASSSS	DEG_SPOP_SBC_1	211:215	Mutation blocking phosphorylation signal	0.7222
p.S209C	DO23846	LUAD	ICGC	ASSSS	DEG_SPOP_SBC_1	211:215	Mutation blocking phosphorylation signal	0.7222
p.S209I	TCGA-AX-A06F	UCEC	TCGA	ASSSS	DEG_SPOP_SBC_1	211:215	Mutation blocking phosphorylation signal	0.7222
p.S209I	DO41752	UCEC	ICGC	ASSSS	DEG_SPOP_SBC_1	211:215	Mutation blocking phosphorylation signal	0.7222
p.R381H	MOLT-13	haematopoietic and lymphoid tissue	COSMIC	MTPPPS	DEG_SCF_FBW7_1	371:376	Mutation blocking phosphorylation signal	0.6389
p.P374S	DO231706	LINC	ICGC	MTPPPS	DEG_SCF_FBW7_1	371:376	Mutation altering degron motif	0.5641
p.G377R	SIDM01664	Prostate Carcinoma	GDSC	MTPPPS	DEG_SCF_FBW7_1	371:376	Mutation rewiring degron network	0.3056
p.G377R	ACH-000952	Prostate Cancer	CCLE	MTPPPS	DEG_SCF_FBW7_1	371:376	Mutation rewiring degron network	0.3056
p.A217S	SIDM00763	Non-Small Cell Lung Carcinoma	GDSC	ASSSS	DEG_SPOP_SBC_1	211:215	Mutation rewiring degron network	0.2778
p.A217S	SIDM00939	Non-Small Cell Lung Carcinoma	GDSC	ASSSS	DEG_SPOP_SBC_1	211:215	Mutation rewiring degron network	0.2778
p.A217S	ACH-000434	Lung Cancer	CCLE	ASSSS	DEG_SPOP_SBC_1	211:215	Mutation rewiring degron network	0.2778
p.A217S	ACH-000826	Lung Cancer	CCLE	ASSSS	DEG_SPOP_SBC_1	211:215	Mutation rewiring degron network	0.2778
p.A217S	CAL-12T	lung	COSMIC	ASSSS	DEG_SPOP_SBC_1	211:215	Mutation rewiring degron network	0.2778
p.A217S	NCI-H1915	lung	COSMIC	ASSSS	DEG_SPOP_SBC_1	211:215	Mutation rewiring degron network	0.2778
p.A378V	C-33-A	cervix	COSMIC	MTPPPS	DEG_SCF_FBW7_1	371:376	Mutation rewiring degron network	0.2778
p.H218Y	TCGA-B5-A3S1	UCEC	TCGA	ASSSS	DEG_SPOP_SBC_1	211:215	Mutation rewiring degron network	0.25
p.H218Y	DO41277	UCEC	ICGC	ASSSS	DEG_SPOP_SBC_1	211:215	Mutation rewiring degron network	0.25
p.R379H	OVK-18	ovary	COSMIC	MTPPPS	DEG_SCF_FBW7_1	371:376	Mutation rewiring degron network	0.25
p.P220S	TCGA-2W-A8YY	CESC	TCGA	ASSSS	DEG_SPOP_SBC_1	211:215	Mutation rewiring degron network	0.1944

Showing 1 to 20 of 58 entries

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Kaplan plot for TFG in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TFG

UniProt ID: Q92734

Entrez ID: 10342

Protein name: Protein TFG (TRK-fused gene protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TFG in