DegronMD

Uniprot ID: Q92734

Source protein: Protein TFG

Source gene: TFG

Class: DEG_SCF_FBW7_1

Location: 371:376

E3 ligase: FBXW7

DEGRON score: 0.9852

ASA_SCORE: 86

COIL: 0.9718

CONS_SCORE: 0.5561

DSS_SCORE: 0.7263

HELIX: 0.0092

FCONS_SCORE: 0.9792

RIG_SCORE: 0.5223

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A382V	TCGA-A5-A0G1	UCEC	TCGA	MTPPPS	DEG_SCF_FBW7_1	0.1667
p.A382V	DO225346	BRCA	ICGC	MTPPPS	DEG_SCF_FBW7_1	0.1667
p.A382V	DO42472	UCEC	ICGC	MTPPPS	DEG_SCF_FBW7_1	0.1667
p.A382V	SIDM00889	Cervical Carcinoma	GDSC	MTPPPS	DEG_SCF_FBW7_1	0.1667
p.A382V	C-33-A	cervix	COSMIC	MTPPPS	DEG_SCF_FBW7_1	0.1667
p.R383C	TCGA-AA-3715	COAD	TCGA	MTPPPS	DEG_SCF_FBW7_1	0.1389
p.R383C	DO8018	COAD	ICGC	MTPPPS	DEG_SCF_FBW7_1	0.1389
p.R385H	TCGA-AA-A010	COAD	TCGA	MTPPPS	DEG_SCF_FBW7_1	0.0833
p.R385H	SIDM00433	T-Lymphoblastic Leukemia	GDSC	MTPPPS	DEG_SCF_FBW7_1	0.0833
p.R385H	ACH-000795	Leukemia	CCLE	MTPPPS	DEG_SCF_FBW7_1	0.0833
p.R385H	MOLT-13	haematopoietic_and_lymphoid_tissue	COSMIC	MTPPPS	DEG_SCF_FBW7_1	0.0833
p.P361Q	TCGA-B5-A3FA	UCEC	TCGA	MTPPPS	DEG_SCF_FBW7_1	0.0556
p.P361Q	DO52402	UCEC	ICGC	MTPPPS	DEG_SCF_FBW7_1	0.0556
p.T372A	DO227906	COCA	ICGC	MTPPPS	DEG_SCF_FBW7_1	0.825
p.A382S	DO228948	LICA	ICGC	MTPPPS	DEG_SCF_FBW7_1	0.1667
p.R385L	DO229019	LICA	ICGC	MTPPPS	DEG_SCF_FBW7_1	0.0833
p.G362C	DO229035	LICA	ICGC	MTPPPS	DEG_SCF_FBW7_1	0.0833
p.P374S	DO231706	LINC	ICGC	MTPPPS	DEG_SCF_FBW7_1	0.5641
p.R385C	DO45299	LIRI	ICGC	MTPPPS	DEG_SCF_FBW7_1	0.0833
p.T364P	SIDM00967	Ovarian Carcinoma	GDSC	MTPPPS	DEG_SCF_FBW7_1	0.1389
p.T364P	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	MTPPPS	DEG_SCF_FBW7_1	0.1389
p.T364P	SIDM00309	Mesothelioma	GDSC	MTPPPS	DEG_SCF_FBW7_1	0.1389
p.T364P	SIDM00431	T-Lymphoblastic Leukemia	GDSC	MTPPPS	DEG_SCF_FBW7_1	0.1389
p.T364P	SIDM01409	Bladder Carcinoma	GDSC	MTPPPS	DEG_SCF_FBW7_1	0.1389
p.R383H	SIDM00238	Ovarian Carcinoma	GDSC	MTPPPS	DEG_SCF_FBW7_1	0.1389
p.R383H	SIDM00365	Small Cell Lung Carcinoma	GDSC	MTPPPS	DEG_SCF_FBW7_1	0.1389
p.R383H	ACH-000947	Ovarian Cancer	CCLE	MTPPPS	DEG_SCF_FBW7_1	0.1389
p.R383H	ACH-002196	Lung Cancer	CCLE	MTPPPS	DEG_SCF_FBW7_1	0.1389
p.R383H	OVK-18	ovary	COSMIC	MTPPPS	DEG_SCF_FBW7_1	0.1389
p.P386L	SIDM00415	B-Cell Non-Hodgkin's Lymphoma	GDSC	MTPPPS	DEG_SCF_FBW7_1	0.0556
p.P386L	ACH-001639	Leukemia	CCLE	MTPPPS	DEG_SCF_FBW7_1	0.0556
p.P386L	ROS-50	haematopoietic_and_lymphoid_tissue	COSMIC	MTPPPS	DEG_SCF_FBW7_1	0.0556
p.G377R	SIDM01664	Prostate Carcinoma	GDSC	MTPPPS	DEG_SCF_FBW7_1	0.3056
p.G377R	ACH-000952	Prostate Cancer	CCLE	MTPPPS	DEG_SCF_FBW7_1	0.3056
p.R379H	OVK-18	ovary	COSMIC	MTPPPS	DEG_SCF_FBW7_1	0.25
p.A378V	C-33-A	cervix	COSMIC	MTPPPS	DEG_SCF_FBW7_1	0.2778
p.R381H	MOLT-13	haematopoietic_and_lymphoid_tissue	COSMIC	MTPPPS	DEG_SCF_FBW7_1	0.6389
p.P382L	ROS-50	haematopoietic_and_lymphoid_tissue	COSMIC	MTPPPS	DEG_SCF_FBW7_1	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: MTPPPS

Degron related mutations and impact score

Drug responses associated with TFG mutations

All proteins holding degron of MTPPPS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q92734	Protein TFG	DEG_SCF_FBW7_1	371:376	MTPPPS	FBXW7	0.9852	More...