DegronMD - O43474(KLF4)

GO - Biological processes (BP): canonical Wnt signaling pathway [GO:0060070]; cellular response to growth factor stimulus [GO:0071363]; cellular response to laminar fluid shear stress [GO:0071499]; cellular response to leukemia inhibitory factor [GO:1990830]; defense response to tumor cell [GO:0002357]; epidermal cell differentiation [GO:0009913]; epidermis morphogenesis [GO:0048730]; fat cell differentiation [GO:0045444]; mesodermal cell fate determination [GO:0007500]; negative regulation of angiogenesis [GO:0016525]; negative regulation of cell migration involved in sprouting angiogenesis [GO:0090051]; negative regulation of cell population proliferation [GO:0008285]; negative regulation of chemokine (C-X-C motif) ligand 2 production [GO:2000342]; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [GO:0043154]; negative regulation of G1/S transition of mitotic cell cycle [GO:2000134]; negative regulation of gene expression [GO:0010629]; negative regulation of heterotypic cell-cell adhesion [GO:0034115]; negative regulation of inflammatory response [GO:0050728]; negative regulation of interleukin-8 production [GO:0032717]; negative regulation of leukocyte adhesion to arterial endothelial cell [GO:1904998]; negative regulation of NF-kappaB transcription factor activity [GO:0032088]; negative regulation of response to cytokine stimulus [GO:0060761]; negative regulation of transcription, DNA-templated [GO:0045892]; negative regulation of transcription by RNA polymerase II [GO:0000122]; positive regulation of cellular protein metabolic process [GO:0032270]; positive regulation of core promoter binding [GO:1904798]; positive regulation of gene expression [GO:0010628]; positive regulation of hemoglobin biosynthetic process [GO:0046985]; positive regulation of miRNA transcription [GO:1902895]; positive regulation of nitric oxide biosynthetic process [GO:0045429]; positive regulation of protein metabolic process [GO:0051247]; positive regulation of sprouting angiogenesis [GO:1903672]; positive regulation of telomerase activity [GO:0051973]; positive regulation of transcription, DNA-templated [GO:0045893]; positive regulation of transcription by RNA polymerase II [GO:0045944]; post-embryonic camera-type eye development [GO:0031077]; post-embryonic hemopoiesis [GO:0035166]; regulation of axon regeneration [GO:0048679]; regulation of blastocyst development [GO:0120222]; regulation of cell differentiation [GO:0045595]; regulation of transcription by RNA polymerase II [GO:0006357]; response to retinoic acid [GO:0032526]; stem cell population maintenance [GO:0019827]; transcription, DNA-templated [GO:0006351] View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G402C	TCGA-44-7667	LUAD	TCGA	MMLTPPSS	DEG_SCF_FBW7_1	391:398	Mutation rewiring degron network	0.2222
p.G402C	DO23830	LUAD	ICGC	MMLTPPSS	DEG_SCF_FBW7_1	391:398	Mutation rewiring degron network	0.2222
p.V124M	TCGA-5M-AAT6	COAD	TCGA	ASSSS	DEG_SPOP_SBC_1	130:134	Mutation rewiring degron network	0.1667
p.V124M	DO223703	COAD	ICGC	ASSSS	DEG_SPOP_SBC_1	130:134	Mutation rewiring degron network	0.1667
p.R383M	TCGA-AX-A2HC	UCEC	TCGA	MMLTPPSS	DEG_SCF_FBW7_1	391:398	Mutation rewiring degron network	0.1111
p.R383M	DO41572	UCEC	ICGC	MMLTPPSS	DEG_SCF_FBW7_1	391:398	Mutation rewiring degron network	0.1111
p.S129P	TCGA-CA-6717	COAD	TCGA	ASSSS	DEG_SPOP_SBC_1	130:134	Mutation rewiring degron network	0.3056
p.S129P	DO8264	COAD	ICGC	ASSSS	DEG_SPOP_SBC_1	130:134	Mutation rewiring degron network	0.3056
p.R390W	TCGA-DH-5141	LGG	TCGA	MMLTPPSS	DEG_SCF_FBW7_1	391:398	Mutation rewiring degron network	0.3056
p.R390W	DO22221	LGG	ICGC	MMLTPPSS	DEG_SCF_FBW7_1	391:398	Mutation rewiring degron network	0.3056
p.R390W	SIDM00336	Melanoma	GDSC	MMLTPPSS	DEG_SCF_FBW7_1	391:398	Mutation rewiring degron network	0.3056
p.R390W	ACH-000881	Skin Cancer	CCLE	MMLTPPSS	DEG_SCF_FBW7_1	391:398	Mutation rewiring degron network	0.3056
p.R390W	MEL-JUSO	skin	COSMIC	MMLTPPSS	DEG_SCF_FBW7_1	391:398	Mutation rewiring degron network	0.3056
p.A394T	TCGA-HU-8602	STAD	TCGA	MMLTPPSS	DEG_SCF_FBW7_1	391:398	Mutation altering degron motif	0.7139
p.A394T	DO47829	STAD	ICGC	MMLTPPSS	DEG_SCF_FBW7_1	391:398	Mutation altering degron motif	0.7139
p.R383T	DO1076	BRCA	ICGC	MMLTPPSS	DEG_SCF_FBW7_1	391:398	Mutation rewiring degron network	0.1111
p.T393N	DO228976	LICA	ICGC	MMLTPPSS	DEG_SCF_FBW7_1	391:398	Mutation altering degron motif	0.7055
p.P389T	DO229029	LICA	ICGC	MMLTPPSS	DEG_SCF_FBW7_1	391:398	Mutation rewiring degron network	0.2778
p.A121V	SIDM01619	Endometrial Carcinoma	GDSC	ASSSS	DEG_SPOP_SBC_1	130:134	Mutation rewiring degron network	0.0833
p.A121V	ACH-000984	Endometrial/Uterine Cancer	CCLE	ASSSS	DEG_SPOP_SBC_1	130:134	Mutation rewiring degron network	0.0833
p.S138N	ACH-001991	Primary	CCLE	ASSSS	DEG_SPOP_SBC_1	130:134	Mutation rewiring degron network	0.2222
p.L137F	SW684	soft tissue	COSMIC	ASSSS	DEG_SPOP_SBC_1	130:134	Mutation rewiring degron network	0.25
p.K142N	H513	pleura	COSMIC	ASSSS	DEG_SPOP_SBC_1	130:134	Mutation rewiring degron network	0.1111
p.D128E	NCI-H727	lung	COSMIC	ASSSS	DEG_SPOP_SBC_1	130:134	Mutation rewiring degron network	0.2778
p.S134L	IGROV-1	ovary	COSMIC	ASSSS	DEG_SPOP_SBC_1	130:134	Mutation altering degron motif	0.7667
p.Q123H	NCI-H2227	lung	COSMIC	ASSSS	DEG_SPOP_SBC_1	130:134	Mutation rewiring degron network	0.1389

Kaplan plot for KLF4 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

KLF4

UniProt ID: O43474

Entrez ID: 9314

Protein name: Krueppel-like factor 4 (Epithelial zinc finger protein EZF) (Gut-enriched krueppel-like factor)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for KLF4 in