DegronMD

Uniprot ID: O43474

Source protein: Krueppel-like factor 4

Source gene: KLF4

Class: DEG_SCF_FBW7_1

Location: 391:398

E3 ligase: FBXW7

DEGRON score: 0.9633

ASA_SCORE: 73.5125

COIL: 0.8479

CONS_SCORE: 0.1764

DSS_SCORE: 0.4773

HELIX: 0.0185

FCONS_SCORE: -0.0039

RIG_SCORE: 0.6521

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G402C	TCGA-44-7667	LUAD	TCGA	MMLTPPSS	DEG_SCF_FBW7_1	0.2222
p.G402C	DO23830	LUAD	ICGC	MMLTPPSS	DEG_SCF_FBW7_1	0.2222
p.R383M	TCGA-AX-A2HC	UCEC	TCGA	MMLTPPSS	DEG_SCF_FBW7_1	0.1111
p.R383M	DO41572	UCEC	ICGC	MMLTPPSS	DEG_SCF_FBW7_1	0.1111
p.R390W	TCGA-DH-5141	LGG	TCGA	MMLTPPSS	DEG_SCF_FBW7_1	0.3056
p.R390W	DO22221	LGG	ICGC	MMLTPPSS	DEG_SCF_FBW7_1	0.3056
p.R390W	SIDM00336	Melanoma	GDSC	MMLTPPSS	DEG_SCF_FBW7_1	0.3056
p.R390W	ACH-000881	Skin Cancer	CCLE	MMLTPPSS	DEG_SCF_FBW7_1	0.3056
p.R390W	MEL-JUSO	skin	COSMIC	MMLTPPSS	DEG_SCF_FBW7_1	0.3056
p.A394T	TCGA-HU-8602	STAD	TCGA	MMLTPPSS	DEG_SCF_FBW7_1	0.7139
p.A394T	DO47829	STAD	ICGC	MMLTPPSS	DEG_SCF_FBW7_1	0.7139
p.R383T	DO1076	BRCA	ICGC	MMLTPPSS	DEG_SCF_FBW7_1	0.1111
p.T393N	DO228976	LICA	ICGC	MMLTPPSS	DEG_SCF_FBW7_1	0.7055
p.P389T	DO229029	LICA	ICGC	MMLTPPSS	DEG_SCF_FBW7_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43474	Krueppel-like factor 4	DEG_SCF_FBW7_1	391:398	MMLTPPSS	FBXW7	0.9633	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons