DegronMD - P50548(ERF)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S168P	TCGA-AA-3877	COAD	TCGA	ACSSS	DEG_SPOP_SBC_1	164:168	Mutation altering degron motif	0.6752
p.S280L	TCGA-BR-7197	STAD	TCGA	LAYTPSPT	DEG_SCF_FBW7_1	275:282	Mutation altering degron motif	0.6556
p.S168F	TCGA-BR-7716	STAD	TCGA	ACSSS	DEG_SPOP_SBC_1	164:168	Mutation altering degron motif	0.7982
p.P420L	TCGA-D5-6928	COAD	TCGA	LAPPPPPPQIKV	DEG_ODPH_VHL_1	416:427	Mutation altering degron motif	0.6471
p.S368F	TCGA-EE-A2GD	SKCM	TCGA	ASSSS	DEG_SPOP_SBC_1	364:368	Mutation altering degron motif	0.9093
p.P285L	TCGA-EE-A2GJ	SKCM	TCGA	LAYTPSPT	DEG_SCF_FBW7_1	275:282	Mutation rewiring degron network	0.25
p.S362F	TCGA-EE-A3AB	SKCM	TCGA	ASSSS	DEG_SPOP_SBC_1	364:368	Mutation rewiring degron network	0.2778
p.S367F	TCGA-EE-A3JD	SKCM	TCGA	ASSSS	DEG_SPOP_SBC_1	364:368	Mutation altering degron motif	0.9093
p.S168Y	TCGA-FD-A3SS	BLCA	TCGA	ACSSS	DEG_SPOP_SBC_1	164:168	Mutation altering degron motif	0.712
p.G414V	TCGA-IB-7651	PAAD	TCGA	LAPPPPPPQIKV	DEG_ODPH_VHL_1	416:427	Mutation rewiring degron network	0.2778
p.A417V	TCGA-XK-AAIW	PRAD	TCGA	LAPPPPPPQIKV	DEG_ODPH_VHL_1	416:427	Mutation altering degron motif	0.6936
p.G376R	DO219758	CESC	ICGC	ASSSS	DEG_SPOP_SBC_1	364:368	Mutation substituting flanking lysine	0.2222
p.E432K	DO51639	CESC	ICGC	LAPPPPPPQIKV	DEG_ODPH_VHL_1	416:427	Mutation rewiring degron network	0.1944
p.D416N	DO49939	CESC	ICGC	LAPPPPPPQIKV	DEG_ODPH_VHL_1	416:427	Mutation altering degron motif	0.6932
p.E430Q	DO48989	CESC	ICGC	LAPPPPPPQIKV	DEG_ODPH_VHL_1	416:427	Mutation rewiring degron network	0.25
p.R412S	DO229029	LICA	ICGC	LAPPPPPPQIKV	DEG_ODPH_VHL_1	416:427	Mutation rewiring degron network	0.2222
p.D375E	DO45281	LIRI	ICGC	ASSSS	DEG_SPOP_SBC_1	364:368	Mutation rewiring degron network	0.1389
p.R412L	DO25189	LUAD	ICGC	LAPPPPPPQIKV	DEG_ODPH_VHL_1	416:427	Mutation rewiring degron network	0.2222
p.P169L	DO220886	MELA	ICGC	ACSSS	DEG_SPOP_SBC_1	164:168	Mutation blocking phosphorylation signal	0.75
p.R408H	DO46657	PAAD	ICGC	LAPPPPPPQIKV	DEG_ODPH_VHL_1	416:427	Mutation rewiring degron network	0.1111
p.D370A	DO37491	SKCM	ICGC	ASSSS	DEG_SPOP_SBC_1	364:368	Mutation blocking phosphorylation signal	0.7222
p.S292F	DO50299	SKCM	ICGC	LAYTPSPT	DEG_SCF_FBW7_1	275:282	Mutation rewiring degron network	0.0556
p.R412C	DO37991	SKCM	ICGC	LAPPPPPPQIKV	DEG_ODPH_VHL_1	416:427	Mutation rewiring degron network	0.2222
p.S287F	DO38057	SKCM	ICGC	LAYTPSPT	DEG_SCF_FBW7_1	275:282	Mutation rewiring degron network	0.1944
p.G433V	DO38495	STAD	ICGC	LAPPPPPPQIKV	DEG_ODPH_VHL_1	416:427	Mutation rewiring degron network	0.1667
p.R411W	DO38619	STAD	ICGC	LAPPPPPPQIKV	DEG_ODPH_VHL_1	416:427	Mutation rewiring degron network	0.1944
p.R411W	DO38259	STAD	ICGC	LAPPPPPPQIKV	DEG_ODPH_VHL_1	416:427	Mutation rewiring degron network	0.1944
p.R418H	DO43306	UCEC	ICGC	LAPPPPPPQIKV	DEG_ODPH_VHL_1	416:427	Mutation altering degron motif	0.8244
p.R418H	DO43755	UCEC	ICGC	LAPPPPPPQIKV	DEG_ODPH_VHL_1	416:427	Mutation altering degron motif	0.8244
p.P174T	DO41903	UCEC	ICGC	ACSSS	DEG_SPOP_SBC_1	164:168	Mutation rewiring degron network	0.1667
p.R162Q	DO42608	UCEC	ICGC	ACSSS	DEG_SPOP_SBC_1	164:168	Mutation rewiring degron network	0.2778
p.P374Q	SIDM01293	Colorectal Carcinoma	GDSC	ASSSS	DEG_SPOP_SBC_1	364:368	Mutation rewiring degron network	0.1667
p.A413T	SIDM00789	Colorectal Carcinoma	GDSC	LAPPPPPPQIKV	DEG_ODPH_VHL_1	416:427	Mutation rewiring degron network	0.25
p.A413T	SIDM01251	T-Cell Non-Hodgkin's Lymphoma	GDSC	LAPPPPPPQIKV	DEG_ODPH_VHL_1	416:427	Mutation rewiring degron network	0.25
p.A413T	ACH-000509	Lymphoma	CCLE	LAPPPPPPQIKV	DEG_ODPH_VHL_1	416:427	Mutation rewiring degron network	0.25
p.A413T	ACH-000997	Colon/Colorectal Cancer	CCLE	LAPPPPPPQIKV	DEG_ODPH_VHL_1	416:427	Mutation rewiring degron network	0.25
p.A413T	ACH-001061	Colon/Colorectal Cancer	CCLE	LAPPPPPPQIKV	DEG_ODPH_VHL_1	416:427	Mutation rewiring degron network	0.25
p.A413T	ACH-002240	Lymphoma	CCLE	LAPPPPPPQIKV	DEG_ODPH_VHL_1	416:427	Mutation rewiring degron network	0.25
p.A413T	H9	haematopoietic and lymphoid tissue	COSMIC	LAPPPPPPQIKV	DEG_ODPH_VHL_1	416:427	Mutation rewiring degron network	0.25
p.A413T	HCT-15	large intestine	COSMIC	LAPPPPPPQIKV	DEG_ODPH_VHL_1	416:427	Mutation rewiring degron network	0.25
p.S431L	SIDM00917	Acute Myeloid Leukemia	GDSC	LAPPPPPPQIKV	DEG_ODPH_VHL_1	416:427	Mutation blocking phosphorylation signal	0.6667
p.S431L	ACH-002218	Leukemia	CCLE	LAPPPPPPQIKV	DEG_ODPH_VHL_1	416:427	Mutation blocking phosphorylation signal	0.6667
p.S431L	CESS	haematopoietic and lymphoid tissue	COSMIC	LAPPPPPPQIKV	DEG_ODPH_VHL_1	416:427	Mutation blocking phosphorylation signal	0.6667
p.S265C	SIDM00971	Breast Carcinoma	GDSC	LAYTPSPT	DEG_SCF_FBW7_1	275:282	Mutation rewiring degron network	0.0556
p.S265C	ACH-000828	Breast Cancer	CCLE	LAYTPSPT	DEG_SCF_FBW7_1	275:282	Mutation rewiring degron network	0.0556
p.F375L	SIDM00375	Head and Neck Carcinoma	GDSC	ASSSS	DEG_SPOP_SBC_1	364:368	Mutation rewiring degron network	0.1389
p.F375L	ACH-002305	Head and Neck Cancer	CCLE	ASSSS	DEG_SPOP_SBC_1	364:368	Mutation rewiring degron network	0.1389
p.F375L	SKN-3	upper aerodigestive tract	COSMIC	ASSSS	DEG_SPOP_SBC_1	364:368	Mutation rewiring degron network	0.1389
p.S365L	SIDM00756	Non-Small Cell Lung Carcinoma	GDSC	ASSSS	DEG_SPOP_SBC_1	364:368	Mutation altering degron motif	0.6556
p.S365L	ACH-000886	Lung Cancer	CCLE	ASSSS	DEG_SPOP_SBC_1	364:368	Mutation altering degron motif	0.6556
p.S365L	NCI-H2009	lung	COSMIC	ASSSS	DEG_SPOP_SBC_1	364:368	Mutation altering degron motif	0.6556
p.S363L	SIDM00737	Non-Small Cell Lung Carcinoma	GDSC	ASSSS	DEG_SPOP_SBC_1	364:368	Mutation rewiring degron network	0.3056
p.S363L	ACH-000904	Lung Cancer	CCLE	ASSSS	DEG_SPOP_SBC_1	364:368	Mutation rewiring degron network	0.3056
p.S363L	ACH-001362	Lung Cancer	CCLE	ASSSS	DEG_SPOP_SBC_1	364:368	Mutation rewiring degron network	0.3056
p.S363L	NCI-H1770	lung	COSMIC	ASSSS	DEG_SPOP_SBC_1	364:368	Mutation rewiring degron network	0.3056
p.E432D	SIDM00999	Bladder Carcinoma	GDSC	LAPPPPPPQIKV	DEG_ODPH_VHL_1	416:427	Mutation rewiring degron network	0.1944
p.E432D	ACH-000973	Bladder Cancer	CCLE	LAPPPPPPQIKV	DEG_ODPH_VHL_1	416:427	Mutation rewiring degron network	0.1944
p.E432D	639-V	urinary tract	COSMIC	LAPPPPPPQIKV	DEG_ODPH_VHL_1	416:427	Mutation rewiring degron network	0.1944
p.T273S	SIDM00261	Ewing's Sarcoma	GDSC	LAYTPSPT	DEG_SCF_FBW7_1	275:282	Mutation rewiring degron network	0.2778
p.Y287C	ACH-000972	Endometrial/Uterine Cancer	CCLE	LAYTPSPT	DEG_SCF_FBW7_1	275:282	Mutation rewiring degron network	0.1944
p.R160H	ACH-001786	Colon/Colorectal Cancer	CCLE	ACSSS	DEG_SPOP_SBC_1	164:168	Mutation rewiring degron network	0.2222
p.S290L	NCI-H2009	lung	COSMIC	LAYTPSPT	DEG_SCF_FBW7_1	275:282	Mutation rewiring degron network	0.1111
p.S356L	CESS	haematopoietic and lymphoid tissue	COSMIC	ASSSS	DEG_SPOP_SBC_1	364:368	Mutation rewiring degron network	0.1111
p.E357D	639-V	urinary tract	COSMIC	ASSSS	DEG_SPOP_SBC_1	364:368	Mutation blocking phosphorylation signal	0.5833
p.S288L	NCI-H1770	lung	COSMIC	LAYTPSPT	DEG_SCF_FBW7_1	275:282	Mutation rewiring degron network	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ERF

UniProt ID: P50548

Entrez ID: 2077

Protein name: ETS domain-containing transcription factor ERF (Ets2 repressor factor) (PE-2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ERF in