DegronMD

Uniprot ID: P50548

Source protein: ETS domain-containing transcription factor ERF

Source gene: ERF

Class: DEG_SCF_FBW7_1

Location: 275:282

E3 ligase: FBXW7

DEGRON score: 0.9324

ASA_SCORE: 75.4375

COIL: 0.9073

CONS_SCORE: 0.6498

DSS_SCORE: 0.5258

HELIX: 0.0674

FCONS_SCORE: 1.2553

RIG_SCORE: 0.6888

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S280L	TCGA-BR-7197	STAD	TCGA	LAYTPSPT	DEG_SCF_FBW7_1	0.6556
p.P285L	TCGA-EE-A2GJ	SKCM	TCGA	LAYTPSPT	DEG_SCF_FBW7_1	0.25
p.S292F	DO50299	SKCM	ICGC	LAYTPSPT	DEG_SCF_FBW7_1	0.0556
p.S287F	DO38057	SKCM	ICGC	LAYTPSPT	DEG_SCF_FBW7_1	0.1944
p.S265C	SIDM00971	Breast Carcinoma	GDSC	LAYTPSPT	DEG_SCF_FBW7_1	0.0556
p.S265C	ACH-000828	Breast Cancer	CCLE	LAYTPSPT	DEG_SCF_FBW7_1	0.0556
p.T273S	SIDM00261	Ewing's Sarcoma	GDSC	LAYTPSPT	DEG_SCF_FBW7_1	0.2778
p.Y287C	ACH-000972	Endometrial/Uterine Cancer	CCLE	LAYTPSPT	DEG_SCF_FBW7_1	0.1944
p.S290L	NCI-H2009	lung	COSMIC	LAYTPSPT	DEG_SCF_FBW7_1	0.1111
p.S288L	NCI-H1770	lung	COSMIC	LAYTPSPT	DEG_SCF_FBW7_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P50548	ETS domain-containing transcription factor ERF	DEG_SCF_FBW7_1	275:282	LAYTPSPT	FBXW7	0.9324	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons