DegronMD

Uniprot ID: P50548

Source protein: ETS domain-containing transcription factor ERF

Source gene: ERF

Class: DEG_SPOP_SBC_1

Location: 164:168

E3 ligase: SPOP

DEGRON score: 0.9976

ASA_SCORE: 52.72

COIL: 0.883

CONS_SCORE: 0.2631

DSS_SCORE: 0.5295

HELIX: 0.0738

FCONS_SCORE: 0.5027

RIG_SCORE: 0.6091

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S168P	TCGA-AA-3877	COAD	TCGA	ACSSS	DEG_SPOP_SBC_1	0.6752
p.S168F	TCGA-BR-7716	STAD	TCGA	ACSSS	DEG_SPOP_SBC_1	0.7982
p.S168Y	TCGA-FD-A3SS	BLCA	TCGA	ACSSS	DEG_SPOP_SBC_1	0.712
p.P169L	DO220886	MELA	ICGC	ACSSS	DEG_SPOP_SBC_1	0.75
p.P174T	DO41903	UCEC	ICGC	ACSSS	DEG_SPOP_SBC_1	0.1667
p.R162Q	DO42608	UCEC	ICGC	ACSSS	DEG_SPOP_SBC_1	0.2778
p.R160H	ACH-001786	Colon/Colorectal Cancer	CCLE	ACSSS	DEG_SPOP_SBC_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60870	DNA/RNA-binding protein KIN17	DEG_SPOP_SBC_1	211:215	ACSSS	SPOP	0.8953	More...
P50548	ETS domain-containing transcription factor ERF	DEG_SPOP_SBC_1	164:168	ACSSS	SPOP	0.9976	More...
Q6UWW8	Carboxylesterase 3	DEG_SPOP_SBC_1	280:284	ACSSS	SPOP	0.642	More...
Q86WB0	Zinc finger C3HC-type protein 1	DEG_SPOP_SBC_1	257:261	ACSSS	SPOP	0.6254	More...
Q9HCB6	Spondin-1	DEG_SPOP_SBC_1	453:457	ACSSS	SPOP	0.9527	More...
Q2M3G4	Protein Shroom1	DEG_SPOP_SBC_1	246:250	ACSSS	SPOP	0.8924	More...
Q9H019	Mitochondrial fission regulator 1-like	DEG_SPOP_SBC_1	221:225	ACSSS	SPOP	0.9141	More...
A6NNM3	RIMS-binding protein 3B	DEG_SPOP_SBC_1	269:273	ACSSS	SPOP	0.513	More...
P0CF97	Protein FAM200B	DEG_SPOP_SBC_1	19:23	ACSSS	SPOP	0.8048	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons