DegronMD - Q86WB0(ZC3HC1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R23C	TCGA-DK-A1A3	BLCA	TCGA	SPEGTPQK	DEG_SCF_SKP2-CKS1_1	24:31	Mutation rewiring degron network	0.3056
p.R23C	DO558	BLCA	ICGC	SPEGTPQK	DEG_SCF_SKP2-CKS1_1	24:31	Mutation rewiring degron network	0.3056
p.A257V	TCGA-F4-6703	COAD	TCGA	ACSSS	DEG_SPOP_SBC_1	257:261	Mutation altering degron motif	0.5825
p.A257V	DO48391	BLCA	ICGC	ACSSS	DEG_SPOP_SBC_1	257:261	Mutation altering degron motif	0.5825
p.A257V	DO9908	COAD	ICGC	ACSSS	DEG_SPOP_SBC_1	257:261	Mutation altering degron motif	0.5825
p.E38K	TCGA-FD-A5BX	BLCA	TCGA	SPEGTPQK	DEG_SCF_SKP2-CKS1_1	24:31	Mutation rewiring degron network	0.1389
p.E38K	TCGA-K4-A54R	BLCA	TCGA	SPEGTPQK	DEG_SCF_SKP2-CKS1_1	24:31	Mutation rewiring degron network	0.1389
p.E38K	DO44079	BLCA	ICGC	SPEGTPQK	DEG_SCF_SKP2-CKS1_1	24:31	Mutation rewiring degron network	0.1389
p.E38K	DO48611	BLCA	ICGC	SPEGTPQK	DEG_SCF_SKP2-CKS1_1	24:31	Mutation rewiring degron network	0.1389
p.R271L	DO3892	BRCA	ICGC	ACSSS	DEG_SPOP_SBC_1	257:261	Mutation rewiring degron network	0.0556
p.T271A	DO229010	COCA	ICGC	ACSSS	DEG_SPOP_SBC_1	257:261	Mutation rewiring degron network	0.0556
p.T271A	DO229013	COCA	ICGC	ACSSS	DEG_SPOP_SBC_1	257:261	Mutation rewiring degron network	0.0556
p.T271A	DO229016	COCA	ICGC	ACSSS	DEG_SPOP_SBC_1	257:261	Mutation rewiring degron network	0.0556
p.T271A	DO229003	COCA	ICGC	ACSSS	DEG_SPOP_SBC_1	257:261	Mutation rewiring degron network	0.0556
p.T271A	DO229005	COCA	ICGC	ACSSS	DEG_SPOP_SBC_1	257:261	Mutation rewiring degron network	0.0556
p.S252C	DO233722	GACA	ICGC	ACSSS	DEG_SPOP_SBC_1	257:261	Mutation rewiring degron network	0.1944
p.S23Y	DO14171	HNSC	ICGC	SPEGTPQK	DEG_SCF_SKP2-CKS1_1	24:31	Mutation rewiring degron network	0.3056
p.T28N	DO229028	LICA	ICGC	SPEGTPQK	DEG_SCF_SKP2-CKS1_1	24:31	Mutation altering degron motif	0.8166
p.T28N	SIDM00940	Breast Carcinoma	GDSC	SPEGTPQK	DEG_SCF_SKP2-CKS1_1	24:31	Mutation altering degron motif	0.8166
p.T28N	SIDM01363	Squamous Cell Lung Carcinoma	GDSC	SPEGTPQK	DEG_SCF_SKP2-CKS1_1	24:31	Mutation altering degron motif	0.8166
p.H15Q	DO229034	LICA	ICGC	SPEGTPQK	DEG_SCF_SKP2-CKS1_1	24:31	Mutation rewiring degron network	0.0833
p.E263K	DO233293	NACA	ICGC	ACSSS	DEG_SPOP_SBC_1	257:261	Mutation rewiring degron network	0.2778
p.A41V	DO232224	PBCA	ICGC	SPEGTPQK	DEG_SCF_SKP2-CKS1_1	24:31	Mutation rewiring degron network	0.0556
p.G264S	DO47140	RECA	ICGC	ACSSS	DEG_SPOP_SBC_1	257:261	Mutation rewiring degron network	0.25
p.S252L	DO37406	SKCM	ICGC	ACSSS	DEG_SPOP_SBC_1	257:261	Mutation rewiring degron network	0.1944
p.S252L	DO43154	UCEC	ICGC	ACSSS	DEG_SPOP_SBC_1	257:261	Mutation rewiring degron network	0.1944
p.Y21F	DO229272	THCA	ICGC	SPEGTPQK	DEG_SCF_SKP2-CKS1_1	24:31	Mutation rewiring degron network	0.25
p.P261L	DO42977	UCEC	ICGC	ACSSS	DEG_SPOP_SBC_1	257:261	Mutation altering degron motif	0.7582
p.P29S	SIDM00777	Colorectal Carcinoma	GDSC	SPEGTPQK	DEG_SCF_SKP2-CKS1_1	24:31	Mutation altering degron motif	0.6752
p.P29S	NCI-H508	large intestine	COSMIC	SPEGTPQK	DEG_SCF_SKP2-CKS1_1	24:31	Mutation altering degron motif	0.6752
p.R25T	SIDM00895	B-Cell Non-Hodgkin's Lymphoma	GDSC	SPEGTPQK	DEG_SCF_SKP2-CKS1_1	24:31	Mutation altering degron motif	0.7876
p.R25T	BC-3	haematopoietic and lymphoid tissue	COSMIC	SPEGTPQK	DEG_SCF_SKP2-CKS1_1	24:31	Mutation altering degron motif	0.7876
p.C258Y	SIDM00619	Thyroid Gland Carcinoma	GDSC	ACSSS	DEG_SPOP_SBC_1	257:261	Mutation altering degron motif	0.5976
p.C258Y	ACH-002397	Thyroid Cancer	CCLE	ACSSS	DEG_SPOP_SBC_1	257:261	Mutation altering degron motif	0.5976
p.C258Y	KMH-2	thyroid	COSMIC	ACSSS	DEG_SPOP_SBC_1	257:261	Mutation altering degron motif	0.5976
p.M270V	WM793B	skin	COSMIC	ACSSS	DEG_SPOP_SBC_1	257:261	Mutation rewiring degron network	0.0833

Kaplan plot for ZC3HC1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ZC3HC1

UniProt ID: Q86WB0

Entrez ID: 51530

Protein name: Zinc finger C3HC-type protein 1 (Nuclear-interacting partner of ALK) (hNIPA) (Nuclear-interacting partner of anaplastic lymphoma kinase)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ZC3HC1 in