DegronMD

Uniprot ID: Q86WB0

Source protein: Zinc finger C3HC-type protein 1

Source gene: ZC3HC1

Class: DEG_SPOP_SBC_1

Location: 257:261

E3 ligase: SPOP

DEGRON score: 0.6254

ASA_SCORE: 52.58

COIL: 0.7416

CONS_SCORE: 0.4108

DSS_SCORE: 0.0094

HELIX: 0.1628

FCONS_SCORE: 0.7746

RIG_SCORE: 0.8788

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A257V	TCGA-F4-6703	COAD	TCGA	ACSSS	DEG_SPOP_SBC_1	0.5825
p.A257V	DO48391	BLCA	ICGC	ACSSS	DEG_SPOP_SBC_1	0.5825
p.A257V	DO9908	COAD	ICGC	ACSSS	DEG_SPOP_SBC_1	0.5825
p.R271L	DO3892	BRCA	ICGC	ACSSS	DEG_SPOP_SBC_1	0.0556
p.T271A	DO229010	COCA	ICGC	ACSSS	DEG_SPOP_SBC_1	0.0556
p.T271A	DO229013	COCA	ICGC	ACSSS	DEG_SPOP_SBC_1	0.0556
p.T271A	DO229016	COCA	ICGC	ACSSS	DEG_SPOP_SBC_1	0.0556
p.T271A	DO229003	COCA	ICGC	ACSSS	DEG_SPOP_SBC_1	0.0556
p.T271A	DO229005	COCA	ICGC	ACSSS	DEG_SPOP_SBC_1	0.0556
p.S252C	DO233722	GACA	ICGC	ACSSS	DEG_SPOP_SBC_1	0.1944
p.E263K	DO233293	NACA	ICGC	ACSSS	DEG_SPOP_SBC_1	0.2778
p.G264S	DO47140	RECA	ICGC	ACSSS	DEG_SPOP_SBC_1	0.25
p.S252L	DO37406	SKCM	ICGC	ACSSS	DEG_SPOP_SBC_1	0.1944
p.S252L	DO43154	UCEC	ICGC	ACSSS	DEG_SPOP_SBC_1	0.1944
p.P261L	DO42977	UCEC	ICGC	ACSSS	DEG_SPOP_SBC_1	0.7582
p.C258Y	SIDM00619	Thyroid Gland Carcinoma	GDSC	ACSSS	DEG_SPOP_SBC_1	0.5976
p.C258Y	ACH-002397	Thyroid Cancer	CCLE	ACSSS	DEG_SPOP_SBC_1	0.5976
p.C258Y	KMH-2	thyroid	COSMIC	ACSSS	DEG_SPOP_SBC_1	0.5976
p.M270V	WM793B	skin	COSMIC	ACSSS	DEG_SPOP_SBC_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60870	DNA/RNA-binding protein KIN17	DEG_SPOP_SBC_1	211:215	ACSSS	SPOP	0.8953	More...
P50548	ETS domain-containing transcription factor ERF	DEG_SPOP_SBC_1	164:168	ACSSS	SPOP	0.9976	More...
Q6UWW8	Carboxylesterase 3	DEG_SPOP_SBC_1	280:284	ACSSS	SPOP	0.642	More...
Q86WB0	Zinc finger C3HC-type protein 1	DEG_SPOP_SBC_1	257:261	ACSSS	SPOP	0.6254	More...
Q9HCB6	Spondin-1	DEG_SPOP_SBC_1	453:457	ACSSS	SPOP	0.9527	More...
Q2M3G4	Protein Shroom1	DEG_SPOP_SBC_1	246:250	ACSSS	SPOP	0.8924	More...
Q9H019	Mitochondrial fission regulator 1-like	DEG_SPOP_SBC_1	221:225	ACSSS	SPOP	0.9141	More...
A6NNM3	RIMS-binding protein 3B	DEG_SPOP_SBC_1	269:273	ACSSS	SPOP	0.513	More...
P0CF97	Protein FAM200B	DEG_SPOP_SBC_1	19:23	ACSSS	SPOP	0.8048	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons