DegronMD - O60870(KIN)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E185K	TCGA-05-4417	LUAD	TCGA	EGKEQEVPTF	DEG_COP1_1	182:191	Mutation altering degron motif	0.7022
p.E185K	DO23570	LUAD	ICGC	EGKEQEVPTF	DEG_COP1_1	182:191	Mutation altering degron motif	0.7022
p.Q176H	TCGA-22-0940	LUSC	TCGA	EGKEQEVPTF	DEG_COP1_1	182:191	Mutation rewiring degron network	0.1667
p.Q176H	DO26794	LUSC	ICGC	EGKEQEVPTF	DEG_COP1_1	182:191	Mutation rewiring degron network	0.1667
p.S219T	TCGA-BR-8680	STAD	TCGA	ACSSS	DEG_SPOP_SBC_1	211:215	Mutation rewiring degron network	0.2222
p.S219T	DO47769	STAD	ICGC	ACSSS	DEG_SPOP_SBC_1	211:215	Mutation rewiring degron network	0.2222
p.P189S	TCGA-D3-A3C7	SKCM	TCGA	EGKEQEVPTF	DEG_COP1_1	182:191	Mutation altering degron motif	0.6752
p.P189S	DO47569	SKCM	ICGC	EGKEQEVPTF	DEG_COP1_1	182:191	Mutation altering degron motif	0.6752
p.S215F	TCGA-HQ-A2OE	BLCA	TCGA	ACSSS	DEG_SPOP_SBC_1	211:215	Mutation altering degron motif	0.7982
p.S215F	DO540	BLCA	ICGC	ACSSS	DEG_SPOP_SBC_1	211:215	Mutation altering degron motif	0.7982
p.E193K	DO230326	COCA	ICGC	EGKEQEVPTF	DEG_COP1_1	182:191	Mutation rewiring degron network	0.2778
p.S213N	DO228254	EOPC	ICGC	ACSSS	DEG_SPOP_SBC_1	211:215	Mutation altering degron motif	0.818
p.E174K	DO233284	GACA	ICGC	EGKEQEVPTF	DEG_COP1_1	182:191	Mutation rewiring degron network	0.1111
p.Q186K	DO228971	LICA	ICGC	EGKEQEVPTF	DEG_COP1_1	182:191	Mutation altering degron motif	0.5833
p.T190N	DO46368	OV	ICGC	EGKEQEVPTF	DEG_COP1_1	182:191	Mutation altering degron motif	0.7055
p.C212Y	SIDM00373	Endometrial Carcinoma	GDSC	ACSSS	DEG_SPOP_SBC_1	211:215	Mutation altering degron motif	0.5976
p.I173L	SIDM00322	Esophageal Squamous Cell Carcinoma	GDSC	EGKEQEVPTF	DEG_COP1_1	182:191	Mutation rewiring degron network	0.0833
p.I173L	ACH-000561	Esophageal Cancer	CCLE	EGKEQEVPTF	DEG_COP1_1	182:191	Mutation rewiring degron network	0.0833
p.I173L	T-T	oesophagus	COSMIC	EGKEQEVPTF	DEG_COP1_1	182:191	Mutation rewiring degron network	0.0833
p.N198S	SIDM00683	Prostate Carcinoma	GDSC	EGKEQEVPTF	DEG_COP1_1	182:191	Mutation rewiring degron network	0.1389
p.N198S	ACH-000977	lymph node	CCLE	EGKEQEVPTF	DEG_COP1_1	182:191	Mutation rewiring degron network	0.1389
p.N198S	LNCaP-Clone-FGC	prostate	COSMIC	EGKEQEVPTF	DEG_COP1_1	182:191	Mutation rewiring degron network	0.1389
p.A211T	SIDM00217	Colorectal Carcinoma	GDSC	ACSSS	DEG_SPOP_SBC_1	211:215	Mutation altering degron motif	0.7139
p.A211T	ACH-000999	Colon/Colorectal Cancer	CCLE	ACSSS	DEG_SPOP_SBC_1	211:215	Mutation altering degron motif	0.7139
p.A211T	SNU-1040	large intestine	COSMIC	ACSSS	DEG_SPOP_SBC_1	211:215	Mutation altering degron motif	0.7139

Kaplan plot for KIN in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

KIN

UniProt ID: O60870

Entrez ID: 22944

Protein name: DNA/RNA-binding protein KIN17 (Binding to curved DNA) (KIN, antigenic determinant of recA protein homolog)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for KIN in