DegronMD

Uniprot ID: O60870

Source protein: DNA/RNA-binding protein KIN17

Source gene: KIN

Class: DEG_SPOP_SBC_1

Location: 211:215

E3 ligase: SPOP

DEGRON score: 0.8953

ASA_SCORE: 62.44

COIL: 0.7388

CONS_SCORE: 0.2825

DSS_SCORE: 0.4231

HELIX: 0.0894

FCONS_SCORE: 0.7953

RIG_SCORE: 0.6401

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S219T	TCGA-BR-8680	STAD	TCGA	ACSSS	DEG_SPOP_SBC_1	0.2222
p.S219T	DO47769	STAD	ICGC	ACSSS	DEG_SPOP_SBC_1	0.2222
p.S215F	TCGA-HQ-A2OE	BLCA	TCGA	ACSSS	DEG_SPOP_SBC_1	0.7982
p.S215F	DO540	BLCA	ICGC	ACSSS	DEG_SPOP_SBC_1	0.7982
p.S213N	DO228254	EOPC	ICGC	ACSSS	DEG_SPOP_SBC_1	0.818
p.C212Y	SIDM00373	Endometrial Carcinoma	GDSC	ACSSS	DEG_SPOP_SBC_1	0.5976
p.A211T	SIDM00217	Colorectal Carcinoma	GDSC	ACSSS	DEG_SPOP_SBC_1	0.7139
p.A211T	ACH-000999	Colon/Colorectal Cancer	CCLE	ACSSS	DEG_SPOP_SBC_1	0.7139
p.A211T	SNU-1040	large_intestine	COSMIC	ACSSS	DEG_SPOP_SBC_1	0.7139

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60870	DNA/RNA-binding protein KIN17	DEG_SPOP_SBC_1	211:215	ACSSS	SPOP	0.8953	More...
P50548	ETS domain-containing transcription factor ERF	DEG_SPOP_SBC_1	164:168	ACSSS	SPOP	0.9976	More...
Q6UWW8	Carboxylesterase 3	DEG_SPOP_SBC_1	280:284	ACSSS	SPOP	0.642	More...
Q86WB0	Zinc finger C3HC-type protein 1	DEG_SPOP_SBC_1	257:261	ACSSS	SPOP	0.6254	More...
Q9HCB6	Spondin-1	DEG_SPOP_SBC_1	453:457	ACSSS	SPOP	0.9527	More...
Q2M3G4	Protein Shroom1	DEG_SPOP_SBC_1	246:250	ACSSS	SPOP	0.8924	More...
Q9H019	Mitochondrial fission regulator 1-like	DEG_SPOP_SBC_1	221:225	ACSSS	SPOP	0.9141	More...
A6NNM3	RIMS-binding protein 3B	DEG_SPOP_SBC_1	269:273	ACSSS	SPOP	0.513	More...
P0CF97	Protein FAM200B	DEG_SPOP_SBC_1	19:23	ACSSS	SPOP	0.8048	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons