DegronMD

Uniprot ID: Q2M3G4

Source protein: Protein Shroom1

Source gene: SHROOM1

Class: DEG_SPOP_SBC_1

Location: 246:250

E3 ligase: SPOP

DEGRON score: 0.8924

ASA_SCORE: 64.18

COIL: 0.8134

CONS_SCORE: 0.6235

DSS_SCORE: 0.4491

HELIX: 0.129

FCONS_SCORE: 1.2215

RIG_SCORE: 0.6372

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R240Q	TCGA-EO-A22R	UCEC	TCGA	ACSSS	DEG_SPOP_SBC_1	0.1667
p.R240Q	DO42713	UCEC	ICGC	ACSSS	DEG_SPOP_SBC_1	0.1667
p.L252R	DO233913	GACA	ICGC	ACSSS	DEG_SPOP_SBC_1	0.2778
p.A239E	DO229027	LICA	ICGC	ACSSS	DEG_SPOP_SBC_1	0.1389
p.P238S	DO44806	LICA	ICGC	ACSSS	DEG_SPOP_SBC_1	0.1111
p.G236S	DO35083	PACA	ICGC	ACSSS	DEG_SPOP_SBC_1	0.0556
p.F260Y	SIDM02059	Colorectal Carcinoma	GDSC	ACSSS	DEG_SPOP_SBC_1	0.0556
p.C247R	SIDM01608	Endometrial Carcinoma	GDSC	ACSSS	DEG_SPOP_SBC_1	0.719
p.C247R	ACH-000990	Endometrial/Uterine Cancer	CCLE	ACSSS	DEG_SPOP_SBC_1	0.719

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60870	DNA/RNA-binding protein KIN17	DEG_SPOP_SBC_1	211:215	ACSSS	SPOP	0.8953	More...
P50548	ETS domain-containing transcription factor ERF	DEG_SPOP_SBC_1	164:168	ACSSS	SPOP	0.9976	More...
Q6UWW8	Carboxylesterase 3	DEG_SPOP_SBC_1	280:284	ACSSS	SPOP	0.642	More...
Q86WB0	Zinc finger C3HC-type protein 1	DEG_SPOP_SBC_1	257:261	ACSSS	SPOP	0.6254	More...
Q9HCB6	Spondin-1	DEG_SPOP_SBC_1	453:457	ACSSS	SPOP	0.9527	More...
Q2M3G4	Protein Shroom1	DEG_SPOP_SBC_1	246:250	ACSSS	SPOP	0.8924	More...
Q9H019	Mitochondrial fission regulator 1-like	DEG_SPOP_SBC_1	221:225	ACSSS	SPOP	0.9141	More...
A6NNM3	RIMS-binding protein 3B	DEG_SPOP_SBC_1	269:273	ACSSS	SPOP	0.513	More...
P0CF97	Protein FAM200B	DEG_SPOP_SBC_1	19:23	ACSSS	SPOP	0.8048	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons