DegronMD

Uniprot ID: Q9H019

Source protein: Mitochondrial fission regulator 1-like

Source gene: MTFR1L

Class: DEG_SPOP_SBC_1

Location: 221:225

E3 ligase: SPOP

DEGRON score: 0.9141

ASA_SCORE: 76.42

COIL: 0.8588

CONS_SCORE: 0.4614

DSS_SCORE: 0.1561

HELIX: 0.1232

FCONS_SCORE: 0.7502

RIG_SCORE: 0.6742

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S224L	TCGA-AX-A1CE	UCEC	TCGA	ACSSS	DEG_SPOP_SBC_1	0.8778
p.S224L	DO42280	UCEC	ICGC	ACSSS	DEG_SPOP_SBC_1	0.8778
p.S224L	SIDM00118	Colorectal Carcinoma	GDSC	ACSSS	DEG_SPOP_SBC_1	0.8778
p.S224L	HCC2998	large_intestine	COSMIC	ACSSS	DEG_SPOP_SBC_1	0.8778
p.C213Y	TCGA-CV-A45P	HNSC	TCGA	ACSSS	DEG_SPOP_SBC_1	0.1111
p.C213Y	DO219026	HNSC	ICGC	ACSSS	DEG_SPOP_SBC_1	0.1111
p.S212L	HCC2998	large_intestine	COSMIC	ACSSS	DEG_SPOP_SBC_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60870	DNA/RNA-binding protein KIN17	DEG_SPOP_SBC_1	211:215	ACSSS	SPOP	0.8953	More...
P50548	ETS domain-containing transcription factor ERF	DEG_SPOP_SBC_1	164:168	ACSSS	SPOP	0.9976	More...
Q6UWW8	Carboxylesterase 3	DEG_SPOP_SBC_1	280:284	ACSSS	SPOP	0.642	More...
Q86WB0	Zinc finger C3HC-type protein 1	DEG_SPOP_SBC_1	257:261	ACSSS	SPOP	0.6254	More...
Q9HCB6	Spondin-1	DEG_SPOP_SBC_1	453:457	ACSSS	SPOP	0.9527	More...
Q2M3G4	Protein Shroom1	DEG_SPOP_SBC_1	246:250	ACSSS	SPOP	0.8924	More...
Q9H019	Mitochondrial fission regulator 1-like	DEG_SPOP_SBC_1	221:225	ACSSS	SPOP	0.9141	More...
A6NNM3	RIMS-binding protein 3B	DEG_SPOP_SBC_1	269:273	ACSSS	SPOP	0.513	More...
P0CF97	Protein FAM200B	DEG_SPOP_SBC_1	19:23	ACSSS	SPOP	0.8048	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons