DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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CGC
Degron:
ACSSS
Uniprot ID:
Q9HCB6
Source protein:
Spondin-1
Source gene:
SPON1
Class:
DEG_SPOP_SBC_1
Location:
453:457
E3 ligase:
SPOP
DEGRON score:
0.9527
ASA_SCORE:
49.24
COIL:
0.7204
CONS_SCORE:
0.4799
DSS_SCORE:
0.308
HELIX:
0.143
FCONS_SCORE:
0.8881
RIG_SCORE:
0.7232
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
Drug responses associated with SPON1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of ACSSS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O60870
DNA/RNA-binding protein KIN17
DEG_SPOP_SBC_1
211:215
ACSSS
SPOP
0.8953
More...
P50548
ETS domain-containing transcription factor ERF
DEG_SPOP_SBC_1
164:168
ACSSS
SPOP
0.9976
More...
Q6UWW8
Carboxylesterase 3
DEG_SPOP_SBC_1
280:284
ACSSS
SPOP
0.642
More...
Q86WB0
Zinc finger C3HC-type protein 1
DEG_SPOP_SBC_1
257:261
ACSSS
SPOP
0.6254
More...
Q9HCB6
Spondin-1
DEG_SPOP_SBC_1
453:457
ACSSS
SPOP
0.9527
More...
Q2M3G4
Protein Shroom1
DEG_SPOP_SBC_1
246:250
ACSSS
SPOP
0.8924
More...
Q9H019
Mitochondrial fission regulator 1-like
DEG_SPOP_SBC_1
221:225
ACSSS
SPOP
0.9141
More...
A6NNM3
RIMS-binding protein 3B
DEG_SPOP_SBC_1
269:273
ACSSS
SPOP
0.513
More...
P0CF97
Protein FAM200B
DEG_SPOP_SBC_1
19:23
ACSSS
SPOP
0.8048
More...