DegronMD

Uniprot ID: Q6UWW8

Source protein: Carboxylesterase 3

Source gene: CES3

Class: DEG_SPOP_SBC_1

Location: 280:284

E3 ligase: SPOP

DEGRON score: 0.642

ASA_SCORE: 60.48

COIL: 0.9736

CONS_SCORE: 0.5259

DSS_SCORE: 0.2591

HELIX: 0.0154

FCONS_SCORE: 0.9685

RIG_SCORE: 0.7085

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.M289I	TCGA-BF-A1Q0	SKCM	TCGA	ACSSS	DEG_SPOP_SBC_1	0.1944
p.M289I	DO47374	SKCM	ICGC	ACSSS	DEG_SPOP_SBC_1	0.1944
p.C281Y	DO230311	COCA	ICGC	ACSSS	DEG_SPOP_SBC_1	0.5976
p.A276T	SIDM00328	Esophageal Squamous Cell Carcinoma	GDSC	ACSSS	DEG_SPOP_SBC_1	0.2222
p.A276T	SIDM00260	Gastric Carcinoma	GDSC	ACSSS	DEG_SPOP_SBC_1	0.2222
p.A276T	SIDM00160	Biliary Tract Carcinoma	GDSC	ACSSS	DEG_SPOP_SBC_1	0.2222
p.A276T	SIDM00248	Gastric Carcinoma	GDSC	ACSSS	DEG_SPOP_SBC_1	0.2222
p.A276T	MKN28	stomach	COSMIC	ACSSS	DEG_SPOP_SBC_1	0.2222
p.A276T	TE-6	oesophagus	COSMIC	ACSSS	DEG_SPOP_SBC_1	0.2222
p.P286L	SIDM00677	Colorectal Carcinoma	GDSC	ACSSS	DEG_SPOP_SBC_1	0.2778
p.P286L	LS-513	large_intestine	COSMIC	ACSSS	DEG_SPOP_SBC_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60870	DNA/RNA-binding protein KIN17	DEG_SPOP_SBC_1	211:215	ACSSS	SPOP	0.8953	More...
P50548	ETS domain-containing transcription factor ERF	DEG_SPOP_SBC_1	164:168	ACSSS	SPOP	0.9976	More...
Q6UWW8	Carboxylesterase 3	DEG_SPOP_SBC_1	280:284	ACSSS	SPOP	0.642	More...
Q86WB0	Zinc finger C3HC-type protein 1	DEG_SPOP_SBC_1	257:261	ACSSS	SPOP	0.6254	More...
Q9HCB6	Spondin-1	DEG_SPOP_SBC_1	453:457	ACSSS	SPOP	0.9527	More...
Q2M3G4	Protein Shroom1	DEG_SPOP_SBC_1	246:250	ACSSS	SPOP	0.8924	More...
Q9H019	Mitochondrial fission regulator 1-like	DEG_SPOP_SBC_1	221:225	ACSSS	SPOP	0.9141	More...
A6NNM3	RIMS-binding protein 3B	DEG_SPOP_SBC_1	269:273	ACSSS	SPOP	0.513	More...
P0CF97	Protein FAM200B	DEG_SPOP_SBC_1	19:23	ACSSS	SPOP	0.8048	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons