DegronMD - Q2M3G4(SHROOM1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T17S	TCGA-43-6143	LUSC	TCGA	PASST	DEG_SPOP_SBC_1	13:17	Mutation altering degron motif	0.6005
p.T17S	DO26428	LUSC	ICGC	PASST	DEG_SPOP_SBC_1	13:17	Mutation altering degron motif	0.6005
p.T17I	TCGA-EE-A3AG	SKCM	TCGA	PASST	DEG_SPOP_SBC_1	13:17	Mutation altering degron motif	0.7078
p.T17I	DO37471	SKCM	ICGC	PASST	DEG_SPOP_SBC_1	13:17	Mutation altering degron motif	0.7078
p.R240Q	TCGA-EO-A22R	UCEC	TCGA	ACSSS	DEG_SPOP_SBC_1	246:250	Mutation rewiring degron network	0.1667
p.R240Q	DO42713	UCEC	ICGC	ACSSS	DEG_SPOP_SBC_1	246:250	Mutation rewiring degron network	0.1667
p.G7V	TCGA-FS-A1ZJ	SKCM	TCGA	PASST	DEG_SPOP_SBC_1	13:17	Mutation rewiring degron network	0.1667
p.G7V	DO37956	SKCM	ICGC	PASST	DEG_SPOP_SBC_1	13:17	Mutation rewiring degron network	0.1667
p.S15L	TCGA-GN-A266	SKCM	TCGA	PASST	DEG_SPOP_SBC_1	13:17	Mutation altering degron motif	0.7667
p.S15L	DO37432	SKCM	ICGC	PASST	DEG_SPOP_SBC_1	13:17	Mutation altering degron motif	0.7667
p.D9N	TCGA-UD-AAC1	MESO	TCGA	PASST	DEG_SPOP_SBC_1	13:17	Mutation rewiring degron network	0.2222
p.P13L	DO233210	GACA	ICGC	PASST	DEG_SPOP_SBC_1	13:17	Mutation altering degron motif	0.7582
p.L252R	DO233913	GACA	ICGC	ACSSS	DEG_SPOP_SBC_1	246:250	Mutation rewiring degron network	0.2778
p.A239E	DO229027	LICA	ICGC	ACSSS	DEG_SPOP_SBC_1	246:250	Mutation rewiring degron network	0.1389
p.D59E	DO229037	LICA	ICGC	LLPYLD	LIG_APCC_ABBA_1	54:59	Mutation altering degron motif	0.5647
p.A3T	DO229004	LICA	ICGC	PASST	DEG_SPOP_SBC_1	13:17	Mutation rewiring degron network	0.0556
p.G51E	DO50970	LICA	ICGC	LLPYLD	LIG_APCC_ABBA_1	54:59	Mutation rewiring degron network	0.25
p.P238S	DO44806	LICA	ICGC	ACSSS	DEG_SPOP_SBC_1	246:250	Mutation rewiring degron network	0.1111
p.S49L	DO218075	ORCA	ICGC	LLPYLD	LIG_APCC_ABBA_1	54:59	Mutation blocking phosphorylation signal	0.6389
p.G236S	DO35083	PACA	ICGC	ACSSS	DEG_SPOP_SBC_1	246:250	Mutation rewiring degron network	0.0556
p.P45S	DO38663	STAD	ICGC	LLPYLD	LIG_APCC_ABBA_1	54:59	Mutation rewiring degron network	0.0833
p.A14G	DO229240	THCA	ICGC	PASST	DEG_SPOP_SBC_1	13:17	Mutation altering degron motif	0.6429
p.L4P	DO229084	THCA	ICGC	PASST	DEG_SPOP_SBC_1	13:17	Mutation rewiring degron network	0.0833
p.F260Y	SIDM02059	Colorectal Carcinoma	GDSC	ACSSS	DEG_SPOP_SBC_1	246:250	Mutation rewiring degron network	0.0556
p.P45Q	SIDM00625	Other Sarcomas	GDSC	LLPYLD	LIG_APCC_ABBA_1	54:59	Mutation rewiring degron network	0.0833
p.P45Q	SIDM00480	Ovarian Carcinoma	GDSC	LLPYLD	LIG_APCC_ABBA_1	54:59	Mutation rewiring degron network	0.0833
p.P45Q	SIDM00835	Colorectal Carcinoma	GDSC	LLPYLD	LIG_APCC_ABBA_1	54:59	Mutation rewiring degron network	0.0833
p.P45Q	SIDM00344	Non-Small Cell Lung Carcinoma	GDSC	LLPYLD	LIG_APCC_ABBA_1	54:59	Mutation rewiring degron network	0.0833
p.C247R	SIDM01608	Endometrial Carcinoma	GDSC	ACSSS	DEG_SPOP_SBC_1	246:250	Mutation altering degron motif	0.719
p.C247R	ACH-000990	Endometrial/Uterine Cancer	CCLE	ACSSS	DEG_SPOP_SBC_1	246:250	Mutation altering degron motif	0.719

Kaplan plot for SHROOM1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SHROOM1

UniProt ID: Q2M3G4

Entrez ID: 134549

Protein name: Protein Shroom1 (Apical protein 2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SHROOM1 in