DegronMD

Uniprot ID: Q2M3G4

Source protein: Protein Shroom1

Source gene: SHROOM1

Class: LIG_APCC_ABBA_1

Location: 54:59

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9172

ASA_SCORE: 59.8667

COIL: 0.7727

CONS_SCORE: 0.7694

DSS_SCORE: 0.3212

HELIX: 0.087

FCONS_SCORE: 1.1957

RIG_SCORE: 0.842

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D59E	DO229037	LICA	ICGC	LLPYLD	LIG_APCC_ABBA_1	0.5647
p.G51E	DO50970	LICA	ICGC	LLPYLD	LIG_APCC_ABBA_1	0.25
p.S49L	DO218075	ORCA	ICGC	LLPYLD	LIG_APCC_ABBA_1	0.6389
p.P45S	DO38663	STAD	ICGC	LLPYLD	LIG_APCC_ABBA_1	0.0833
p.P45Q	SIDM00625	Other Sarcomas	GDSC	LLPYLD	LIG_APCC_ABBA_1	0.0833
p.P45Q	SIDM00480	Ovarian Carcinoma	GDSC	LLPYLD	LIG_APCC_ABBA_1	0.0833
p.P45Q	SIDM00835	Colorectal Carcinoma	GDSC	LLPYLD	LIG_APCC_ABBA_1	0.0833
p.P45Q	SIDM00344	Non-Small Cell Lung Carcinoma	GDSC	LLPYLD	LIG_APCC_ABBA_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q2M3G4	Protein Shroom1	LIG_APCC_ABBA_1	54:59	LLPYLD	APC,CDC20,FZR1	0.9172	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons